期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 23, 期 4, 页码 632-638出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2013.01.018
关键词
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资金
- National Institute on Drug Abuse [R01 DA023051]
- National Institute of Neurological Disorders and Stroke [P50 NS19632]
- National Cancer Institute [R01CA152062]
Recent concepts of addiction to drugs (e.g. cocaine) and non-drugs (e.g. gambling) have proposed that these behaviors are the product of an imbalance between three separate, but interacting, neural systems: an impulsive, largely amygdala striatum dependent, neural system that promotes automatic, habitual and salient behaviors; a reflective, mainly prefrontal cortex dependent, neural system for decision-making, forecasting the future consequences of a behavior, and inhibitory control; and the insula that integrates interoception states into conscious feelings and into decision-making processes that are involved in uncertain risk and reward. These systems account for poor decision-making (i.e. prioritizing short-term consequences of a decisional option) leading to more elevated addiction risk and relapse. This article provides neural evidence for this three-systems neural model of addiction.
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