Article
Computer Science, Software Engineering
Zehui Lin, Xiang Gu, Sheng Li, Zhiming Hu, Guoping Wang
Summary: We propose an efficient locomotion technique to reduce cybersickness by aligning visual and vestibular induced self-motion illusion. Our technique stimulates proprioception consistent with the visual sense through intentional head motion, including translational movement and yaw rotation. Through experiments, we find a correlation between the level of cybersickness and the velocity of self motion, with the lowest velocity showing the highest cybersickness level.
IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS
(2023)
Article
Neurosciences
Rami Mooti, Hangue Park
Summary: This study investigated the contribution of cervical proprioception, vision, and vestibular feedback to the dynamic head-trunk orientation error in the yaw direction. The results showed that dynamic cervical proprioception is the most significant sensory modality for reducing the dynamic head-trunk orientation error.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Anat V. Lubetzky, Jennifer L. Kelly, Bryan D. Hujsak, Jenny Liu, Daphna Harel, Maura Cosetti
Summary: The study investigated the response of participants to sensory perturbations using virtual reality technology and portable Head Mounted Displays. Results showed that responses were magnified around the head, and the majority of participants with vestibular disorders moved more in dynamic environments than controls.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Andrew A. McCall, Derek M. Miller, Carey D. Balaban
Summary: The study demonstrates that vestibular nucleus neurons in conscious cats respond well to combined vestibular and hindlimb proprioceptive stimulation, fitting a simple additive model. This suggests that neurons in this region play a key role in adjusting vestibulospinal outflow in response to limb state.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Review
Clinical Neurology
Bingyu Liu, Jiayu Shan, Yong Gu
Summary: The vestibular system plays a crucial role in various cognitive functions, and recent studies have shed light on its neural mechanisms. However, the complex spatiotemporal dynamics of vestibular signals pose challenges in integrating them with other modalities.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Oz Zur, Hadas Ben-Rubi Shimron, Lisa Deutsch, Eli Carmeli
Summary: The study aims to determine the validity, inter- and intra-examiner reliability, and normal performance values of the Zur Balance Scale (ZBS) among individuals aged 29-70 years and introduce the modified version, mZBS. The results show that ZBS is a valid and reliable test, capable of detecting minimal differences in postural control, even in healthy populations.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Riender Happee, Varun Kotian, Ksander N. De Winkel
Summary: This study combines a musculoskeletal neck model with models of sensory integration to examine the role of vestibular, visual, and muscle sensory cues in head-neck stabilization and their relationship to motion sickness. The results show the importance of sensory integration in postural stabilization and suggest that imprecise sensory integration may contribute to motion sickness.
FRONTIERS IN NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Magdalena Janc, Mariola Sliwinska-Kowalska, Piotr Politanski, Marek Kaminski, Magdalena Jozefowicz-Korczynska, Ewa Zamyslowska-Szmytke
Summary: The study validated the method of head-shake static posturography (HS-posturography) in healthy individuals and found it to be more sensitive and specific in diagnosing patients with unilateral vestibular lesions (UV) compared to standard posturography. The addition of head movements improved the reliability of the testing method for group with vestibular impairment.
SCIENTIFIC REPORTS
(2021)
Review
Biology
Zhao Zeng, Ce Zhang, Yong Gu
Summary: Multi-sensory decision making (MSDM) is crucial for making accurate decisions in complex environments. Recent research in computational theory, psychophysical behavior, and neurophysiology has made significant progress in understanding MSDM. By studying a visuo-vestibular heading model system, researchers have uncovered the complex temporal dynamics of vestibular signals in various brain regions, challenging the brain's ability to integrate cues across time and sensory modalities. Moreover, new evidence from higher-level decision-related areas has revised our understanding of how signals from different sensory modalities are processed and accumulated to form a unified perceptual decision.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Neurosciences
Luxin Zhou, Yong Gu
Summary: Accurate self-motion perception is crucial for survival, and it involves multiple sensory cues such as optic flow and inertial motion. Recent studies challenge previous conventional thoughts about the cortical mechanisms underlying visuo-vestibular integration and propose that different temporal component signals may mediate different functions in multisensory self-motion perception.
NEUROSCIENCE BULLETIN
(2023)
Article
Clinical Neurology
Kody R. Campbell, Robert J. Peterka, Peter C. Fino, Lucy Parrington, Jennifer L. Wilhelm, Natalie C. Pettigrew, Laurie A. King
Summary: This study examined the effectiveness of vestibular rehabilitation therapy with and without ABF in improving balance in people with chronic mTBI. Both groups showed improvements in PCSS and SOT scores, with the ABF group demonstrating better results in increasing motor activation and decreasing time delay. This suggests that incorporating motor activation factors in vestibular rehabilitation, possibly with ABF, may lead to more comprehensive assessment of recovery and improved outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Omid A. Zobeiri, Benjamin Ostrander, Jessica Roat, Yuri Agrawal, Kathleen E. Cullen
Summary: Research indicates that damage to the vestibular system significantly alters the statistical characteristics of head movements, particularly evident in tasks that require rapid feedback.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Rehabilitation
Brian J. Loyd, Jane Saviers-Steiger, Annie Fangman, Serene S. Paul, Peter C. Fino, Mark E. Lester, Leland E. Dibble
Summary: The study aimed to quantify the control of linear accelerations at the head and trunk during gait in individuals with unilateral vestibular loss using clinically available inertial measurement units. Participants who underwent vestibular schwannoma resection surgery showed greater impairment in controlling accelerations at the head and trunk without visual sensory information compared to vestibular healthy participants. These impairments were detectable using clinically available inertial measurement units.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Rehabilitation
Anat Lubetzky, Jennifer Kelly, Zhu Wang, Marta Gospodarek, Gene Fu, John Sutera, Bryan D. Hujsak
Summary: This study aimed to test the feasibility and effectiveness of a novel VR application in patients with vestibular disorders. The results showed significant improvements in self-reported and functional outcomes for patients with peripheral hypofunction after participating in vestibular rehabilitation using the app, while only some cases of central patients showed important improvements.
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
(2022)
Article
Clinical Neurology
Kody R. R. Campbell, Laurie A. A. King, Lucy Parrington, Peter C. C. Fino, Prokopios Antonellis, Robert J. J. Peterka
Summary: Imbalance is common and persistent following mild Traumatic Brain Injury (mTBI), with mTBI subjects showing differences in balance dependence on visual cues and increased time delays and decreased motor activation. These findings suggest the importance of therapy aimed at enhancing rapid and vigorous responses to balance perturbations for rehabilitation.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Kathleen E. Cullen
NATURE REVIEWS NEUROSCIENCE
(2019)
Article
Neurosciences
Patrick A. Forbes, Annie Kwan, Brandon G. Rasman, Diana E. Mitchell, Kathleen E. Cullen, Jean-Sebastien Blouin
JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Kazuya Ono, James Keller, Omar Lopez Ramirez, Antonia Gonzalez Garrido, Omid A. Zobeiri, Hui Ho Vanessa Chang, Sarath Vijayakumar, Andrianna Ayiotis, Gregg Duester, Charles C. Della Santina, Sherri M. Jones, Kathleen E. Cullen, Ruth Anne Eatock, Doris K. Wu
NATURE COMMUNICATIONS
(2020)
Editorial Material
Neurosciences
Danielle S. Bassett, Kathleen E. Cullen, Simon B. Eickhoff, Martha J. Farah, Yukiko Goda, Patrick Haggard, Hailan Hu, Yasmin L. Hurd, Sheena A. Josselyn, Baljit S. Khakh, Juergen A. Knoblich, Panayiota Poirazi, Russell A. Poldrack, Marco Prinz, Pieter R. Roelfsema, Tara L. Spires-Jones, Mriganka Sur, Hiroki R. Ueda
NATURE REVIEWS NEUROSCIENCE
(2020)
Article
Biology
Isabelle Mackrous, Jerome Carriot, Kathleen E. Cullen, Maurice J. Chacron
Article
Multidisciplinary Sciences
Jerome Carriot, Kathleen E. Cullen, Maurice J. Chacron
Summary: Weber's law is considered a fundamental principle of perception, but it is an oversimplification with observed violations; perceptual performance exceeds predictions from Weber's law for higher stimulus amplitudes commonly found in natural sensory stimuli; the study reveals the neural basis for violations of Weber's law and how variability contributes to adaptive encoding of natural stimuli.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Isabelle Mackrous, Jerome Carriot, Kathleen E. Cullen
Summary: This study recorded the activity of individual afferents during walking and running in monkeys and found that the encoding of the vestibular system is the same in passive and active conditions, contrary to previous hypotheses. The results suggest that during primate locomotion, the vestibular periphery relays important information to the brain, while context-dependent modulation is centrally controlled.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Jerome Carriot, Graham McAllister, Hamed Hooshangnejad, Isabelle Mackrous, Kathleen E. Cullen, Maurice J. Chacron
Summary: The study examines sensory adaptation to natural and artificial stimuli and finds that adaptation actually reduces coding ambiguity without compromising the optimality of coding under natural stimulation.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Omid A. Zobeiri, Kathleen E. Cullen
Summary: Accurately controlling posture and spatial orientation during self-motion requires integration of vestibular and neck proprioceptive inputs. The anterior vermis of the cerebellum is believed to play a crucial role in transforming sensory information into an estimate of body motion. The response dynamics of Purkinje cells in the anterior vermis show heterogeneity and they encode an intermediate representation of self-motion between head and body motion. This heterogeneity is proposed to underlie the cerebellum's ability to compute the dynamic representation of body motion for postural control and perceptual stability.
Article
Neurosciences
Patrick A. Forbes, Annie Kwan, Diana E. Mitchell, Jean-Sebastien Blouin, Kathleen E. Cullen
Summary: Noninvasive electrical stimulation of the vestibular system (GVS) is a popular tool with various applications, but assumptions about the neural mechanisms underlying GVS have not been directly tested. This study shows that GVS is encoded by vestibular afferents with nonlinear dynamics that differ from current models. GVS produces asymmetric activation and eye movement responses, and the nonlinear neural response leads to a directional bias in the net population response. These findings advance our understanding of GVS and suggest that nonlinear encoding is common in neural processing.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Robyn L. Mildren, Kathleen E. Cullen
Summary: To maintain stable posture, the brain integrates information across multiple sensory systems, including the vestibular system. This study found that the primate vestibular system, independent of visual input, controls head posture during self-motion. Surprisingly, visual information does not modulate the vestibular-driven responses, and autonomic arousal enhances vestibular-evoked responses.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Neurosciences
Kathleen E. Cullen
Summary: The vestibular cerebellum plays a crucial role in maintaining balance and spatial orientation by encoding vestibular information and combining it with external signals to create internal models. It continuously updates neural mechanisms to adapt to changes and ensure accurate motor behavior.
TRENDS IN NEUROSCIENCES
(2023)
Article
Multidisciplinary Sciences
Jennifer L. Millar, Omid A. Zobeiri, Wagner H. Souza, Michael C. Schubert, Kathleen E. Cullen
Summary: Head kinematics are altered in individuals with vestibular schwannoma (VS) during both longer duration and shorter duration gait tasks, showing differences in range of motion and movement variability. Quantifying head kinematics during longer duration gait tasks can provide novel information about how individuals compensate for vestibular loss.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Lin Wang, Omid A. Zobeiri, Jennifer L. Millar, Wagner Souza Silva, Michael C. Schubert, Kathleen E. Cullen
Summary: The study found that continuous head motion exercises are more informative than transient exercises in distinguishing patients from healthy controls, and kinematic measures are predictive of continuous head motion exercises.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Review
Neurosciences
Jessica X. Brooks, Kathleen E. Cullen
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2019)