期刊
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
卷 23, 期 4, 页码 361-369出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.mnh.0000447023.59346.ab
关键词
distal convoluted tubule; hypomagnesemia; magnesium channel; TRPM
资金
- Netherlands Organization for Scientific Research [ZonMw 9120.8026, NWO ALW 818.02.001]
- NWO Veni grant [863.13.010]
- NWO Vici grant [016.130.668]
- European Union [305608]
Purpose of review The tight control of blood magnesium (Mg2+) levels is of central importance for numerous physiological processes. A persistent low Mg2+ status (hypomagnesemia) is associated with severe health risks and is involved in the pathogenesis of type 2 diabetes mellitus, osteoporosis, asthma, and heart and vascular diseases. The current view has expanded significantly as a result of the identification of novel genes and regulatory pathways involved in hypomagnesemic disorders. This review aims to give an up-to-date overview of transient receptor potential melastatin 6 (TRPM6) regulation and its role in the maintenance of Mg2+ homeostasis. Recent findings The epithelial Mg2+ channel TRPM6 is considered to be the Mg2+ entry pathway in the distal convoluted tubule of the kidney, where it functions as gatekeeper for controlling the body's Mg2+ balance. Various factors and hormones contribute not only to the function, but also to the dysregulation of TRPM6, which has a substantial impact on renal Mg2+ handling. Recent genetic and molecular studies have further elucidated the signaling processes of epithelial Mg2+ transport, including their effect on the expression and function of TRPM6. Summary Knowledge of TRPM6 functioning is of vital importance to decipher its role in Mg2+ handling and will, in particular, provide a molecular basis for achieving a better understanding of Mg2+ mal(re) absorption and hence systemic Mg2+ balance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据