Article
Cardiac & Cardiovascular Systems
Shejuti Paul, Mandy Wong, Ehimare Akhabue, Rupal C. Mehta, Holly Kramer, Tamara Isakova, Mercedes R. Carnethon, Myles Wolf, Orlando M. Gutierrez
Summary: In middle-aged adults with few comorbidities, higher levels of fibroblast growth factor 23 (FGF23) were not independently associated with greater risk of cardiovascular events or death. Higher cFGF23 was independently associated with greater risk of heart failure hospitalization.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Aleksandra Marchwicka, Urszula Nowak, Anna Grembowska, Agnieszka Jakuszak, Piotr Poreba, Ewa Marcinkowska
Summary: It has been found that fibroblast growth factor receptors play a crucial role in regulating the vitamin D receptor gene and cell differentiation. Overexpression of fibroblast growth factor receptors in myeloid leukemia cells upregulates the expression of the vitamin D receptor gene and promotes cell differentiation, while it has no effect on the expression and activity of the vitamin D receptor gene in bone cells.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Cornelia Bieri, Arezoo Daryadel, Carla Bettoni, Eva-Maria Pastor-Arroyo, Udo Schnitzbauer, Nati Hernando, Carsten A. Wagner
Summary: Kidneys play an important role in regulating phosphate homeostasis. Mutations in the SLC34A1 gene are associated with various kidney-related diseases, but the specific mutation studied here does not appear to negatively impact phosphate balance.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Anne Cornelissen, Roberta Florescu, Kinan Kneizeh, Christian Cornelissen, Vincent Brandenburg, Elisa Liehn, Alexander Schuh
Summary: Elevated levels of FGF23 are associated with adverse outcomes in patients with cardiovascular disease and chronic kidney failure. In acute heart failure patients, FGF23 levels on the first day of admission are strongly correlated with one-year mortality and can predict outcomes with similar accuracy as traditional risk estimation tools. The assessment of FGF23 in acute heart failure patients may help identify high-risk individuals who require closer monitoring and more aggressive treatment.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Anita Saxena, Trisha Sachan, Amit Gupta, Vishwas Kapoor
Summary: Restricting dietary phosphorus intake is a favorable therapeutic strategy for CKD patients, improving renal function and controlling hyperphosphatemia, which can delay disease progression and prevent cardiovascular disease.
Article
Agriculture, Dairy & Animal Science
Jiakun Yan, Chong Pan, Yanli Liu, Xujie Liao, Jionghao Chen, Yufei Zhu, Xinhuo Huang, Xiaojun Yang, Zhouzheng Ren
Summary: The present study evaluated the effects of dietary supplemental vitamin D-3 on fibroblast growth factor 23 (FGF23) signals, phosphorus homeostasis, and metabolism in laying hens. The results showed that restriction of dietary vitamin D-3 reduced serum phosphorus levels in laying hens and suppressed the expression of FGF23 signaling-related genes.
Article
Endocrinology & Metabolism
Elena Chertok Shacham, Nimra Maman, Tatyana Lazareva, Refaat Masalha, Lila Mahagna, Gala Sela, Avraham Ishay
Summary: The study aims to compare the FGF-23 levels in patients with PHPT, NPHPT, and normal calcium and PTH levels. The findings suggest that NPHPT may be an early stage of PHPT and further research is needed to determine the role of FGF-23 in NPHPT.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Shizhen Zheng, Chao Wang, Hao Yan, Min Xu, Yuejun Du
Summary: This meta-analysis found that elevated blood FGF-23 level is associated with a higher risk of major adverse cardiovascular events, cardiovascular mortality, and all-cause mortality in patients with coronary artery disease (CAD). The study suggests that blood FGF-23 level may provide important predictive information in CAD patients.
Review
Endocrinology & Metabolism
Ignacio Portales-Castillo, Petra Simic
Summary: Bone-mineral ion regulators, such as PTH, FGF23, Klotho, and 1,25(OH)2 vitamin D, play important roles in calcium and phosphate metabolism and cell signaling. These factors are tightly regulated through genetic, epigenetic, and post-translational mechanisms. Epigenetic mechanisms, including DNA methylation and histone modification, have been found to affect the function of these regulators.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Yu-Wei Fang, Jing-Tong Wang, Tzu Yun Lin, Chung-Jen Lee, Tsrang-Neng Jang, Ming-Hsien Tsai, Hung-Hsiang Liou
Summary: This study explored the associations between serum iFGF23 and cFGF23 levels and the Hb level in patients with renal anemia. It was found that iFGF23 and iFGF23/cFGF23 levels were negatively associated with the Hb level, and positively associated with ESA hyporesponsiveness.
FRONTIERS IN MEDICINE
(2023)
Review
Chemistry, Medicinal
Elmira Karimi, Sama Bitarafan, Seyed Mohammad Mousavi, Nikan Zargarzadeh, Pari Mokhtari, Jessie Hawkins, Alipasha Meysamie, Fariba Koohdani
Summary: Oral vitamin D supplementation does not significantly affect serum FGF23 concentrations in patients with chronic kidney disease, and further high-quality trials are needed to confirm the findings.
PHYTOTHERAPY RESEARCH
(2021)
Article
Urology & Nephrology
Junichi Ishigami, Morgan E. Grams, Erin D. Michos, Pamela L. Lutsey, Kunihiro Matsushita
Summary: In a study of middle-to older-age adults in the community, low serum 25-hydroxyvitamin D levels and high serum fibroblast growth factor 23 (FGF23) levels were independently associated with an increased risk of acute kidney injury (AKI). Future research should further explore the underlying mechanisms linking these bone mineral metabolism markers to kidney injury.
KIDNEY INTERNATIONAL REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Fatemeh Meshkini, Sepideh Soltani, Cain C. T. Clark, Vivian Tam, David Meyre, Omid Toupchian, Sahar Saraf-Bank, Shima Abdollahi
Summary: Prior studies on the effect of vitamin D on serum levels of fibroblast growth factor-23 (FGF-23) have produced inconsistent findings. This systematic review and meta-analysis concluded that vitamin D supplementation has no significant effect on serum FGF-23 concentration.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Youn Kyung Kee, Hee Jung Jeon, Jieun Oh, Ajin Cho, Young-Ki Lee, Jong-Woo Yoon, Hyunsuk Kim, Tae-Hyun Yoo, Dong Ho Shin
Summary: The study aimed to investigate the influence of fibroblast growth factor-23 (FGF-23) levels and residual kidney function (RFK) on the development of cardiovascular disease (CVD) in patients undergoing hemodialysis. The results showed that higher FGF-23 levels were associated with lower RFK and higher prevalence of left ventricular diastolic dysfunction. The impact of FGF-23 on CVD development was attenuated by the loss of RFK.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Physiology
Xiaoyi Zhang, Li Zhang, Yingzhen Wen, Mengxian Zhang, Shuangxin Liu, Houqin Xiao
Summary: This study investigated the protective effect and potential mechanism of vitamin D on podocyte injury in diabetic kidney disease (DKD). The results showed that treatment with a vitamin D analogue significantly reduced albuminuria and improved renal pathology in diabetic mice. Furthermore, vitamin D enhanced podocyte autophagy activity, restored the expression of slit diaphragm proteins, and inhibited podocyte apoptosis under diabetic conditions.
KIDNEY & BLOOD PRESSURE RESEARCH
(2023)