期刊
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
卷 18, 期 2, 页码 160-165出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MNH.0b013e32831ec1db
关键词
angiogenesis; kidney; microcirculation; vascular rarefaction
资金
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL085307, R01HL077131] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK073608, R21DK077013] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01 HL077131, R01 HL077131-04, P01 HL085307, HL-77131, P01HL085307, P01 HL085307-02] Funding Source: Medline
- NIDDK NIH HHS [R01 DK073608, R01 DK073608-01A2, DK77013, R21 DK077013, DK-73608] Funding Source: Medline
Purpose of review The prevalence of chronic kidney disease has been growing consistently for the past decades. Renal failure is often associated with defective angiogenesis, and recognition of the contribution of the renal microcirculation to the progression of chronic renal disease may aid in the development of therapeutic interventions. Recent findings Intra-renal proliferation, remodeling, and/or rarefaction of microvessels in response to injury can all aggravate nephron damage, and experimental evidence suggests that they may constitute the early steps in the complex pathways involved in progressive renal injury. Recent studies showed the benefits of targeted interventions deemed to promote neovascularization (e.g. progenitor cells, growth factors) on the ischemic myocardium and brain and in a few models of renal disease. Summary Evidence of aberrant renal microvascular architecture in various forms of renal disease provides the impetus to attempt modulating the renal microcirculation to interfere with the disease process. Targeted interventions to preserve the renal microcirculation may not only decrease the evolving injury in renal vascular disease but also potentially constitute a coadjuvant intervention to become part of a comprehensive management plan to improve the success of parallel strategies to preserve renal function, such as revascularization.
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