期刊
JOURNAL OF NEUROSCIENCE
卷 35, 期 48, 页码 15916-15920出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1813-15.2015
关键词
extrasynaptic receptors; delta-GABA(A) receptor; layer 2/3; pyramidal cells
资金
- National Institutes of Health [R05-EY12124, NS4236301]
Tonic inhibition mediated by extrasynaptic GABA(A) receptors (GABARs) sensing ambient levels of GABA can profoundly alter the membrane input resistance to affect cellular excitability. Therefore, regulation of tonic inhibition is an attractive mechanism to control the levels of cortical firing. In cortical pyramidal cells, tonic inhibition is regulated by age and several neurotransmitters and is affected by stroke and epilepsy. However, the possible role of sensory experience has not been examined. Here, we report that a brief 2-day exposure to dark reduces by 1/3 the inhibitory tonic conductance recorded in layer II/III pyramidal cells of the mouse juvenile (postnatal day 12-27) visual cortex. In these cells, tonic inhibition is carried primarily by GABARs containing the delta subunit. Consistently, the dark exposure reduction in conductance was associated with a reduction in delta subunit levels, which were not affected in control frontal cortex. We propose that a deprivation-induced reduction in tonic inhibition might serve a homeostatic function by increasing the firing levels of cells in deprived cortical circuits.
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