期刊
CURRENT OPINION IN MICROBIOLOGY
卷 20, 期 -, 页码 96-102出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2014.05.002
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资金
- Deutsche Forschungsgemeinschaft [We 2616/7-1, SFB 593, SFB 1021]
- Forschungsforderung gem. 2 Abs. 3 Kooperationsvertrag Universitatsklinikum Giessen und Marburg
- Leibniz Graduate School for Emerging Viral Diseases (EIDIS)
The group of negative-stranded RNA viruses (NSVs) with a segmented genome comprises pathogens like influenza virus (eight segments), Rift Valley fever virus and Hantavirus (three segments), or Lassa virus (two segments). Partitioning the genome allows rapid evolution of new strains by reassortment. Each segment carries a short double-stranded (ds) 'panhandle' structure which serves as promoter. Similar dsRNA structures, however, represent the optimal ligand for RIG-I, a cytoplasmic pathogen sensor of the antiviral interferon response. Thus, segmenting a virus genome can entail an increased RIG-I sensitivity. Here, we outline the astonishingly diverse and efficient strategies by which segmented NSVs are compensating for the elevated number of RIG-I Iigands in their genome.
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