期刊
CURRENT OPINION IN MICROBIOLOGY
卷 16, 期 4, 页码 445-451出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2013.04.010
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资金
- National Institutes of Health [5R01AI077558, 1R21AI105328]
- DFG grant [SP1209/1]
- Graduate School 'Model Systems of Infectious Diseases' of the Leibniz Center for Research on Infectious Diseases.
- [GRK1459]
The continuous multiplication of Plasmodium parasites in red blood cells leads to a rapid increase in parasite numbers and is responsible for the disease symptoms of malaria. Survival and virulence of the parasite are linked to parasite-induced changes of the host red blood cells. These alterations require export of a large number of parasite proteins that are trafficked across multiple membranes to reach the host cell. Two classes of exported proteins are known, those with a conserved Plasmodium export element (PEXEL/HT) or those without this motif (PNEPs). Recent work has revealed new aspects of the determinants required for export of these 2 protein classes, shedding new light on the mode of trafficking during the different transport steps en route to the host cell.
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