期刊
CURRENT OPINION IN MICROBIOLOGY
卷 13, 期 6, 页码 706-711出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2010.09.016
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资金
- NIAID NIH HHS [R01 AI089370, R01 AI064287, R01 AI064287-01] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007215] Funding Source: Medline
The dikaryons of basidiomycete fungi represent an unusual cell type required for complete sexual development. Dikaryon formation occurs via the activities of cell type-specific homeodomain transcription factors, which form regulatory complexes to establish the dikaryotic state. Decades of classical genetic and cell biological studies in mushrooms have provided a foundation for more recent molecular studies in the pathogenic species Ustilago maydis and Cryptococcus neoformans. Studies in these systems have revealed novel mechanisms of regulation that function downstream of classic homeodomain complexes to ensure that dikaryons are established and propagated. Comparisons of these dikaryon-specific networks promise to reveal the nature of regulatory network evolution and the adaptations responsible for driving complex eukaryotic development.
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