期刊
CURRENT OPINION IN MICROBIOLOGY
卷 12, 期 2, 页码 152-160出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2009.01.010
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资金
- Swiss National Science Foundation [3100A0-108186]
- National Library of Medicine at the National Institutes of Health
Single domain response regulators (SD-RRs) are signaling components of two-component phosphorylation pathways that harbor a phosphoryl receiver domain but lack a dedicated output domain. The Escherichia coli protein CheY, the paradigm member of this family, regulates chemotaxis by relaying information between chemoreceptors and the flagellar motor switch. New data provide a more complex picture of CheY-mediated motility control in several bacteria and suggest diverging mechanisms in control of cellular motors. Moreover, advances have been made in understanding cellular functions of SD-RRs beyond chemotaxis. We review recent reports indicating that SD-RRs constitute a family of versatile molecular switches that contribute to cellular organization and dynamics as spatial organizer and/or as allosteric regulators of histidine protein kinases.
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