Article
Nutrition & Dietetics
Jie Pan, Yuhua Hu, Nengzhi Pang, Lili Yang
Summary: This study found an association between dietary niacin intake and nonalcoholic fatty liver disease (NAFLD), suggesting that higher dietary niacin intake may be associated with a lower risk of NAFLD.
Article
Public, Environmental & Occupational Health
Essi Hantikainen, Elin Roos, Rino Bellocco, Alessia D'Antonio, Alessandra Grotta, Hans-Olov Adami, Weimin Ye, Ylva Trolle Lagerros, Stephanie Bonn
Summary: This study investigated the association between fat intake and the incidence of Parkinson disease and found that a higher consumption of large amounts of saturated fat might be associated with an increased risk of Parkinson disease. A diet low in saturated fat may be beneficial for disease prevention.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Oncology
Iman Moussa, Rena S. Day, Ruosha Li, Ahmed Kaseb, Prasun K. Jalal, Carrie Daniel-MacDougall, Rikita I. Hatia, Ahmed Abdelhakeem, Asif Rashid, Yun Shin Chun, Donghui Li, Manal M. Hassan
Summary: This study found an inverse association between monounsaturated fatty acid intake and hepatocellular carcinoma (HCC) risk, and a direct association between total polyunsaturated fatty acid intake and HCC risk. Omega-6 PUFA intake was directly associated with HCC risk, while long-chain omega-3 PUFA intake was inversely associated with HCC risk. No significant association was observed for saturated fat and HCC risk.
Article
Nutrition & Dietetics
Cristina Galarregui, Irene Cantero, Bertha Araceli Marin-Alejandre, J. Ignacio Monreal, Mariana Elorz, Alberto Benito-Boillos, Jose Ignacio Herrero, de la O. Victor, Miguel Ruiz-Canela, Helen Hermana M. Hermsdorff, Josefina Bressan, Josep A. Tur, J. Alfredo Martinez, M. Angeles Zulet, Itziar Abete
Summary: The study found that higher consumption of specific dietary amino acids was associated with poorer liver health, as indicated by liver fat content, liver iron concentration, and ferritin levels. The intake of these amino acids was positively correlated with markers of glucose metabolism.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Nutrition & Dietetics
Camila Farias, Camila Cisternas, Juan Cristobal Gana, Gigliola Alberti, Francisca Echeverria, Luis A. Videla, Lorena Mercado, Yasna Munoz, Rodrigo Valenzuela
Summary: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in pediatrics, and children and adolescents with obesity are at increased risk of the disease. Currently, there is no effective drug therapy in pediatrics, making lifestyle interventions the primary treatment option.
Article
Nutrition & Dietetics
Xiaolin Yao, Xin Xu, Shuo Wang, Dan Xia
Summary: This study found a significant positive association between saturated fatty acid intake and total mortality, while greater consumption of polyunsaturated fatty acids and monounsaturated fatty acids was strongly negatively associated with all-cause death and cardiovascular disease mortality.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Danijela Ristic-Medic, Marijana Kovacic, Marija Takic, Aleksandra Arsic, Snjezana Petrovic, Marija Paunovic, Maja Jovicic, Vesna Vucic
Summary: This study evaluated the effects of calorie-restricted Mediterranean and low-fat diets on patients with NAFLD. Both diets resulted in significant weight loss and improvements in liver status and cardiometabolic markers. The Mediterranean diet may have additional benefits compared to the low-fat diet by improving fatty acid profiles and FLI in NAFLD patients.
Review
Biochemistry & Molecular Biology
Guilherme da Silva Ferreira, Sergio Catanozi, Marisa Passarelli
Summary: Restriction in sodium intake is important for reducing cardiovascular diseases, but the influence on the development of nonalcoholic fatty liver disease (NAFLD) has been less studied. This systematic review compiled evidence from human and animal studies to examine the influence of dietary sodium intake patterns on NAFLD markers;
Article
Nutrition & Dietetics
Fumika Oku, Akinori Hara, Hiromasa Tsujiguchi, Keita Suzuki, Kim-Oanh Pham, Fumihiko Suzuki, Sakae Miyagi, Masaharu Nakamura, Chie Takazawa, Kuniko Sato, Toru Yanagisawa, Takayuki Kannon, Atsushi Tajima, Hiroyuki Nakamura
Summary: This study investigated the association between fat intake and hyperuricemia in Japanese males, finding that saturated fatty acid, monounsaturated fatty acid, and polyunsaturated fatty acid levels were significantly lower in the high uric acid group. In individuals with reduced kidney function, lipid intake was negatively associated with hyperuricemia.
Article
Chemistry, Medicinal
Kyung-A Byun, Seyeon Oh, Myeongjoo Son, Chul-Hyun Park, Kuk Hui Son, Kyunghee Byun
Summary: It was found in this study that ECE and DK can attenuate NAFLD by decreasing weight gain and food intake, reducing inflammation, increasing lymphangiogenesis, and modulating lymphatic vessel permeability.
Review
Cell Biology
Qiannan Ren, Qiming Sun, Junfen Fu
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely associated with a high-fat diet. Autophagy plays a protective role in NAFLD, but dysfunction of liver autophagy may contribute to the development of NAFLD.
Review
Cell Biology
Ke-Qiong Deng, Xuewei Huang, Fang Lei, Xiao-Jing Zhang, Peng Zhang, Zhi-Gang She, Jingjing Cai, Yan-Xiao Ji, Hongliang Li
Summary: Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide due to the global pandemic of metabolic diseases. This article highlights the links between hepatic lipid species and their mechanisms in mediating the pathogenesis of NAFLD, with a focus on saturated fatty acids, cholesterol, oxidized phospholipids, and their intermediates.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Natalia Kopiczko, Anna Bobrus-Chociej, Ewa Harasim-Symbor, Eugeniusz Tarasow, Malgorzata Wojtkowska, Adrian Chabowski, Dariusz M. Lebensztejn
Summary: This study aimed to evaluate the serum FA concentration in children with obesity and NAFLD. The results showed that the total FA concentration was significantly higher in obese children and in obese children with NAFLD compared to controls. There was a significant positive correlation between total FA concentration and cholesterol, triacylglycerols, and insulin in children with NAFLD.
Article
Food Science & Technology
Masoumeh Sadeghi, Mehrdad Simani, Noushin Mohammadifard, Mohammad Talaei, Hamidreza Roohafza, Razieh Hassannejad, Nizal Sarrafzadegan
Summary: The study revealed a higher consumption of hydrogenated vegetable oil (HVO) was associated with an increased risk of myocardial infarction, while no significant association was found between other dietary fat sources and the risk of cardiovascular disease.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Mohamed Zaiou, Rim Amrani, Bertrand Rihn, Tahar Hajri
Summary: Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the accumulation of fat in liver cells, increasingly becoming the leading cause of metabolic disorders linked with genetics, lifestyle, diet, and microbiota. Epigenetic processes play a key role in gene expression and NAFLD pathogenesis. Research suggests innovative epigenetic-based strategies for early prevention and treatment of NAFLD.
Review
Biochemistry & Molecular Biology
Vera B. Schrauwen-Hinderling, Marianne Eline Kooi, Patrick Schrauwen
ANTIOXIDANTS & REDOX SIGNALING
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucas Lindeboom, Yvonne M. H. Bruls, Petronella A. van Ewijk, Matthijs K. C. Hesselink, Joachim E. Wildberger, Patrick Schrauwen, Vera B. Schrauwen-Hinderling
MAGNETIC RESONANCE IN MEDICINE
(2017)
Article
Neurosciences
Anne Gemmink, Sabine Daemen, Bram Brouwers, Peter R. Huntjens, Gert Schaart, Esther Moonen-Kornips, Johanna Jorgensen, Joris Hoeks, Patrick Schrauwen, Matthijs K. C. Hesselink
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Physiology
Bernard M. F. M. Duvivier, Nicolaas C. Schaper, Annemarie Koster, Linh van Kan, Harry P. F. Peters, Jos J. Adam, Timo Giesbrecht, Esther Kornips, Martine Hulsbosch, Paul Willems, Matthijs K. C. Hesselink, Patrick Schrauwen, Hans H. C. M. Savelberg
FRONTIERS IN PHYSIOLOGY
(2017)
Article
Endocrinology & Metabolism
Dennis Dahlmans, Alexandre Houzelle, Penelope Andreux, Johanna A. Jorgensen, Xu Wang, Leon J. de Windt, Patrick Schrauwen, Johan Auwerx, Joris Hoeks
MOLECULAR METABOLISM
(2017)
Article
Multidisciplinary Sciences
Jakob Wefers, Dirk van Moorsel, Jan Hansen, Niels J. Connell, Bas Havekes, Joris Hoeks, Wouter D. van Marken Lichtenbelt, Helene Duez, Esther Phielix, Andries Kalsbeek, Mark V. Boekschoten, Guido J. Hooiveld, Matthijs K. C. Hesselink, Sander Kersten, Bart Staels, Frank A. J. L. Scheer, Patrick Schrauwen
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Review
Nutrition & Dietetics
Eva Fechner, Ellen T. H. C. Smeets, Patrick Schrauwen, Ronald P. Mensink
Article
Endocrinology & Metabolism
Jeroen H. P. M. van der Velde, Sebastiaan C. Boone, Esther Winters-van Eekelen, Matthijs K. C. Hesselink, Vera B. Schrauwen-Hinderling, Patrick Schrauwen, Hildo J. Lamb, Frits R. Rosendaal, Renee de Mutsert
Summary: This study found that the number of breaks in sedentary time was not associated with lower liver fat content or reduced insulin resistance. However, engaging in moderate-to-vigorous physical activity in the afternoon or evening was associated with a reduction of up to 25% in insulin resistance. Further research should investigate whether the timing of physical activity also plays an important role in the occurrence of type 2 diabetes.
Article
Nutrition & Dietetics
Jeremy Basset-Sagarminaga, Kay H. M. Roumans, Bas Havekes, Ronald P. Mensink, Harry P. F. Peters, Peter L. Zock, Renee de Mutsert, Jan Boren, Lucas Lindeboom, Patrick Schrauwen, Vera B. Schrauwen-Hinderling
Summary: The study found that reducing the dietary glycemic index and intake of saturated fatty acids, and replacing saturated fatty acids with polyunsaturated fat, can significantly decrease liver fat content and glycemic response.
Article
Nutrition & Dietetics
Charlotte Andriessen, Daniel Doligkeit, Esther Moonen-Kornips, Marco Mensink, Matthijs K. C. Hesselink, Joris Hoeks, Patrick Schrauwen
Summary: The study found that energy expenditure has a day-night rhythm, while the day-night rhythm of carbohydrate and fat oxidation is mainly influenced by food intake. After an extended period of fasting, the absolute rate of fat oxidation rapidly increases, while carbohydrate oxidation gradually decreases.
CLINICAL NUTRITION
(2023)
Article
Physiology
Rodrigo Mancilla, Bram Brouwers, Vera B. Schrauwen-Hinderling, Matthijs K. C. Hesselink, Joris Hoeks, Patrick Schrauwen
Summary: The study found that afternoon exercise training may have superior metabolic benefits for individuals with compromised metabolism, including improvements in insulin sensitivity, suppression of adipose tissue lipolysis, lower fasting glucose levels, enhanced exercise performance, and reduced fat mass.
PHYSIOLOGICAL REPORTS
(2021)
Article
Cell Biology
Renate Schreiber, Clemens Diwoky, Gabriele Schoiswohl, Ursula Feiler, Nuttaporn Wongsiriroj, Mahmoud Abdellatif, Dagmar Kolb, Joris Hoeks, Erin E. Kershaw, Simon Sedej, Patrick Schrauwen, Guenter Haemmerle, Rudolf Zechner
Article
Medicine, Research & Experimental
Bram Brouwers, Vera B. Schrauwen-Hinderling, Tomas Jelenik, Anne Gemmink, Bas Havekes, Yvonne Bruls, Dennis Dahlmans, Michael Roden, Matthijs K. C. Hesselink, Patrick Schrauwen
Meeting Abstract
Endocrinology & Metabolism
J. Wefers, D. van Moorsel, J. Hansen, N. Connell, B. Havekes, F. A. Scheer, J. Hoeks, N. C. Schaper, E. Phielix, M. K. C. Hesselink, P. Schrauwen
Meeting Abstract
Endocrinology & Metabolism
A. Gemmink, S. Daemen, B. Brouwers, J. Hoeks, E. Kornips, G. Schaart, P. Schrauwen, M. K. C. Hesselink