Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Article
Biology
Xiaojing Chu, Anna W. M. Janssen, Hans Koenen, Linzhung Chang, Xuehui He, Irma Joosten, Rinke Stienstra, Yunus Kuijpers, Cisca Wijmenga, Cheng-Jian Xu, Mihai G. Netea, Cees J. Tack, Yang Li, Christoph Buettner
Summary: This study reveals that genetic variants significantly affect T cell composition and susceptibility to type 1 diabetes (T1D). Specifically, the CCR5+ regulatory T cells are associated with T1D through the CCR region, suggesting a shared genetic regulation. In addition, 15 genetic loci that influence immune responses in T1D were identified, including 12 loci that have never been reported in healthy population studies, implying a disease-specific genetic regulation.
Review
Immunology
Zhangyan Jing, Yuan Li, Yumeng Ma, Xiaozhou Zhang, Xin Liang, Xudong Zhang
Summary: This review discusses the recent advances in using biomaterials for immunomodulation in the treatment of type 1 diabetes, which can reduce the side effects of immunosuppressants. The applications include targeted delivery, regulation of autoreactive T cells, and restoration of immune tolerance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Ionut Bebu, Sareh Keshavarzi, Xiaoyu Gao, Barbara H. Braffett, Angelo J. Canty, William H. Herman, Trevor J. Orchard, Samuel Dagogo-Jack, David M. Nathan, John M. Lachin, Andrew D. Paterson
Summary: Genetic factors, including CAD PRS and individual single nucleotide polymorphisms, are strongly associated with the risk of subsequent cardiovascular disease in individuals with type 1 diabetes, beyond established risk factors like age, lipids, blood pressure, and glycemia.
Article
Chemistry, Multidisciplinary
Sungwook Jung, Moufida Ben Nasr, Baharak Bahmani, Vera Usuelli, Jing Zhao, Gianmarco Sabiu, Andy Joe Seelam, Said Movahedi Naini, Hari Baskar Balasubramanian, Youngrong Park, Xiaofei Li, Salma Ayman Khalefa, Vivek Kasinath, MacKenzie D. Williams, Ousama Rachid, Yousef Haik, George C. Tsokos, Clive H. Wasserfall, Mark A. Atkinson, Jonathan S. Bromberg, Wei Tao, Paolo Fiorina, Reza Abdi
Summary: A novel and specific nanodelivery platform targeting high endothelial venules (HEVs) in pancreatic lymph nodes (PLNs) and pancreas is developed to address the limited efficacy, equipoise, or safety issues of immune therapeutics in treating type 1 diabetes (T1D). By encapsulating anti-CD3 mAb in poly(lactic-co-glycolic acid)-poly(ethylene glycol) nanoparticles (NPs) conjugated with MECA79 mAb, the targeted delivery of these NPs improves the accumulation of anti-CD3 mAb in both PLNs and pancreas of nonobese diabetic (NOD) mice. Treatment with MECA79-anti-CD3-NPs significantly reverses T1D in hyperglycemic NOD mice by reducing T effector cell populations and pro-inflammatory cytokine production in PLNs.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Lars Krogvold, Ida Maria Mynarek, Erica Ponzi, Freja Barrett Mork, Trine Witzner Hessel, Trine Roald, Nina Lindblom, Jacob Westman, Peter Barker, Heikki Hyoety, Johnny Ludvigsson, Kristian F. Hanssen, Jesper Johannesen, Knut Dahl-Jorgensen
Summary: The results suggest that antiviral treatment may help preserve insulin production in children and adolescents with new-onset type 1 diabetes.
Review
Endocrinology & Metabolism
Alexia Carre, Federica Vecchio, Malin Flodstrom-Tullberg, Sylvaine You, Roberto Mallone
Summary: The evidence for an association between CVB infection and type 1 diabetes is growing, although a causal relationship has not yet been proven. CVB vaccines have been developed to avoid exposure and are currently in clinical trials. Understanding the immune responses triggered by CVB infection is crucial for maximizing vaccination success and monitoring its interaction with autoimmune onset or prevention.
Article
Medicine, General & Internal
Luisa H. Colorado, Lauren Beecher, Nicola Pritchard, Khaled Al Rashah, Cirous Dehghani, Anthony Russell, Rayaz A. Malik, Nathan Efron, Katie Edwards
Summary: Time-lapsed in vivo corneal confocal microscopy (IVCCM) revealed an increase in whorl region dendritic cell (DC) density in individuals with type 1 diabetes (T1D), but no changes in other DC sub-types or cell dynamics. Furthermore, there were correlations between DC density and lipid parameters, as well as between DC dynamics and renal function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Xuan Chen, Alison H. Affinati, Yungchun Lee, Adina F. Turcu, Norah Lynn Henry, Elena Schiopu, Angel Qin, Megan Othus, Dan Clauw, Nithya Ramnath, Lili Zhao
Summary: This study found that the risk of developing ICI-T1DM is associated with the type of ICI therapy, patient age, and preexisting non-T1DM diabetes. The development of ICI-T1DM does not seem to significantly impact patient survival.
Review
Microbiology
Sonia R. Isaacs, Dylan B. Foskett, Anna J. Maxwell, Emily J. Ward, Clare L. Faulkner, Jessica Y. X. Luo, William D. Rawlinson, Maria E. Craig, Ki Wook Kim
Summary: This article provides an overview of the role of viruses in the development of type 1 diabetes and discusses concerns over bias towards enteroviruses in research. It also highlights current unbiased efforts in characterizing the virome contributing to early development of islet autoimmunity and type 1 diabetes. Additionally, it reviews the candidates of vaccines and antiviral drugs currently being evaluated for the prevention and treatment of type 1 diabetes.
Article
Medicine, Research & Experimental
Melanie R. Shapiro, Xiaoru Dong, Daniel J. Perry, James M. McNichols, Puchong Thirawatananond, Amanda L. Posgai, Leeana D. Peters, Keshav Motwani, Richard S. Musca, Andrew Muir, Patrick Concannon, Laura M. Jacobsen, Clayton E. Mathews, Clive H. Wasserfall, Michael J. Haller, Desmond A. Schatz, Mark A. Atkinson, Maigan A. Brusko, Rhonda L. Bacher, Todd M. Brusko
Summary: This study investigates the immune cell subsets in peripheral blood and their changes in individuals with type 1 diabetes (T1D). The researchers found accelerated immune aging in T1D and identified phenotypes associated with the disease. These findings provide insights for biomarker monitoring and therapeutic interventions.
Article
Endocrinology & Metabolism
Huan Liu, Shirin Geravandi, Ausilia Maria Grasso, Saheri Sikdar, Alberto Pugliese, Kathrin Maedler
Summary: This study found no association between enteroviral infection in the pancreas and T2D diabetes. Despite similarities in inflammatory markers in islets in both T1D and T2D, long-term enteroviral infiltration is a distinct pathological feature of T1D-associated autoimmunity and T1D pancreases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Deborah Osafehinti, Surya N. Mulukutla, Christiane S. Hampe, Ruchi Gaba, Nalini Ram, Michael N. Weedon, Richard A. Oram, Ashok Balasubramanyam
Summary: The genetic risk for type 1 diabetes (T1D) can differentiate the subgroups of ketosis-prone diabetes (KPD). The patients with A+beta- KPD have the highest genetic risk scores (GRS), while those with A-beta+ KPD have the lowest GRS. There is not a significant difference in GRS among different races.
Review
Cell Biology
Mark A. Atkinson, Raghavendra G. Mirmira
Summary: This review discusses emerging concepts regarding the pathogenesis of T1D, highlighting the important roles of multiple cellular constituents and identifying key knowledge gaps that still remain.
Article
Biochemistry & Molecular Biology
Jody Ye, Mihaela Stefan-Lifshitz, Yaron Tomer
Summary: Cathepsin H (CTSH) plays a role in type 1 diabetes (T1D) risk, with genetic and epidemiological studies showing a correlation between T1D risk, high CTSH expression, and beta-cell function decline. Proinflammatory cytokines can downregulate CTSH transcription through DNA methylation, potentially affecting individuals' sensitivity to cytokines and response to environmental factors. This suggests that genetic and environmental influences on a T1D locus are mediated by DNA methylation variability.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Biochemical Research Methods
Sabine Szunerits, Quentin Pagneux, Abir Swaidan, Vladyslav Mishyn, Alain Roussel, Christian Cambillau, David Devos, Ilka Engelmann, Enagnon Kazali Alidjinou, Henri Happy, Rabah Boukherroub
Summary: Point-of-care technologies and testing programs have the potential to improve diagnosis and disease surveillance significantly. With their portable nature, rapid results, and ability to be performed near patients or treatment facilities, these tests are especially useful in situations of limited resources. In the current COVID-19 pandemic, fast, accurate, efficient, and cost-effective point-of-care testing devices are crucial for controlling the spread of the virus.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Letter
Infectious Diseases
Aurelie Guigon, Emmanuel Faure, Chloe Lemaire, Marie-Charlotte Chopin, Claire Tinez, Ady Assaf, Mouna Lazrek, Didier Hober, Laurence Bocket, Ilka Engelmann, Enagnon Kazali Alidjinou
JOURNAL OF INFECTION
(2022)
Article
Infectious Diseases
Enagnon Kazali Alidjinou, Olivier Gaillot, Aurelie Guigon, Claire Tinez, Mouna Lazrek, Laurence Bocket, Ilka Engelmann, Didier Hober
Summary: Infections with SARS-CoV-2 post COVID-19 vaccination are not unusual, especially those occurring more than 14 days after the second vaccine dose. Lack of anti-SARS-CoV-2 neutralizing antibodies may be linked to breakthrough infections even after full vaccination.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2022)
Letter
Infectious Diseases
Enagnon Kazali Alidjinou, Julie Demaret, Laurence Bocket, Fanny Vuotto, Anthony Rabat, Karine Faure, Myriam Labalette, Didier Hober, Guillaume Lefevre
Article
Medicine, General & Internal
Enagnon Kazali Alidjinou, Mickael Hirabidian, Anthony Rabat, Mahdi Ouafi, Magloire Pandoua Nekoua, Famara Sane, Julien Poissy, Didier Hober
Summary: This study found a significant association between levels of IFN alpha and age in COVID-19 patients, which may explain the higher susceptibility of the elderly to severe COVID-19.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
Enagnon Kazali Alidjinou, Julie Demaret, Benedicte Corroyer-Simovic, Fanny Vuotto, Sophie Miczek, Julien Labreuche, Anne Goffard, Jacques Trauet, Daniela Lupau, Arnaud Dendooven, Dominique Huvent-Grelle, Juliette Podvin, Daniel Dreuil, Karine Faure, Dominique Deplanque, Laurence Bocket, Alain Duhamel, Annie Sobaszek, Didier Hober, Michael Hisbergues, Francois Puisieux, Brigitte Autran, Yazdan Yazdanpanah, Myriam Labalette, Guillaume Lefevre
Summary: The study investigated the serum neutralizing activity and T cell response against BA.1 and BA.2 sublineages before and after the administration of the booster vaccine in healthcare workers. The results showed that a low neutralizing activity was observed before the booster dose, but significant increases in neutralizing antibodies against Delta, BA.1, and BA.2 were observed after 3 months. Participants with recent infection maintained stable neutralizing antibody levels against Delta and BA.2, and showed an increase in neutralizing antibodies against BA.1.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Virology
Mahdi Ouafi, Alexandre Regueme, Isabelle Alcaraz, Pierre Riviere, Helene Bazus, Arnaud Salmon-Rousseau, Bertrand Cappeliez, Noemie Cartier, Aurelie Guigon, Mouna Lazrek, Laurence Bocket, Emmanuel Faure, Olivier Robineau, Didier Hober, Enagnon Kazali Alidjinou
Summary: The ongoing outbreak of monkeypox virus is the largest in historically non-endemic countries, with atypical epidemiological and clinical presentations. This study found a significantly lower viral load in oropharyngeal samples compared to lesion samples, indicating that pharyngeal sampling does not provide additional information for the initial diagnosis in patients with typical lesions.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Ambroise Mercier, Antoine Meheut, Enagnon Kazali Alidjinou, Mouna Lazrek, Karine Faure, Didier Hober, Ilka Engelmann
Summary: From 2014 to 2019, no cases of MERS-CoV infection were found among 98 patients returning from endemic areas. However, infections with other respiratory viruses, especially Enterovirus/Rhinoviruses and Influenzaviruses, were common.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Review
Virology
Abdulaziz Alhazmi, Magloire Pandoua Nekoua, Ambroise Mercier, Ines Vergez, Famara Sane, Enagnon Kazali Alidjinou, Didier Hober
Summary: Coxsackieviruses B (CVB) is a common virus that can cause a wide range of diseases. Current approaches to control CVB infections include the development of drugs and vaccines, as well as alternative strategies. These methods have shown potential in preventing and treating CVB infections in vitro and in animal models.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Review
Microbiology
Magloire Pandoua Nekoua, Cyril Debuysschere, Ines Vergez, Corentin Morvan, Chaldam Jespere Mbani, Famara Sane, Enagnon Kazali Alidjinou, Didier Hober
Summary: Viral infections have long been associated with physiological and pathological changes in the endocrine system. The current pandemic of COVID-19 has revealed numerous endocrine complications, highlighting the need to better understand the impact of viral infections on the endocrine system. Several viruses can directly damage endocrine cells or indirectly disrupt the system through the activation of the host antiviral immune response, leading to inflammation or organ-specific autoimmunity. Furthermore, endocrine disorders can also impact susceptibility to viral infections due to the immunoregulatory functions of endocrine hormones.
Article
Hematology
Mathilde Sourisseau, Emmanuel Faure, Helene Behal, Paul Chauvet, Micha Srour, Antoine Capes, Valerie Coiteux, Leonardo Magro, Serge Alfandari, Enagnon Kazali Alidjinou, Nicolas Simon, Fanny Vuotto, Micheline Karam, Karine Faure, Ibrahim Yakoub-Agha, David Beauvais
Summary: Letermovir is an effective drug for CMV infection prophylaxis in adult patients undergoing allo-HCT. A risk-based strategy allows high-risk patients to benefit from letermovir while some low-risk patients can avoid its use.
Letter
Hematology
Nicolas Gazeau, Suman Mitra, Morgane Nudel, Remi Tilmont, Paul Chauvet, Micha Srour, Anne-Sophie Moreau, Pauline Varlet, Enagnon Kazali Alidjinou, Salomon Manier, Franck Morschhauser, Myriam Labalette, Ibrahim Yakoub-Agha, David Beauvais
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Letter
Virology
Enagnon Kazali Alidjinou, Lander De Coninck, Jill Swinnen, Mouna Lazrek, Didier Hober, Jelle Matthijnssens
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Microbiology
Enagnon Kazali Alidjinou, Lander De Coninck, Jill Swinnen, Mouna Lazrek, Didier Hober, Jelle Matthijnssens
Summary: We present the sequences of four complete genomes of parvovirus B19, isolated from amniotic fluid samples obtained from pregnant women with abnormal ultrasound findings in France. The genome sequences are 5,596 nucleotides long and contain long terminal repeats. Several amino acid substitutions were identified in the nonstructural protein NS1.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Infectious Diseases
Alexandre Regueme, Amelie Lesueur, Benoit Catteau, Celia Tillard, Agnes Wacrenier, Noemie Cartier, Mouna Lazrek, Aurelie Guigon, Didier Hober, Enagnon Kazali Alidjinou
Summary: Cases of childhood syphilis are typically caused by congenital transmission, but acquired transmission is rare and often associated with sexual abuse or close contact/nursing with infected family members. This case study presents a 14-month-old girl who acquired syphilis through intrafamilial infection and subsequently transmitted the disease to her mother.