Article
Infectious Diseases
Michelle Odonkor, Fahd Naufal, Beatriz Munoz, Harran Mkocha, Mabula Kasubi, Meraf Wolle, Sheila West
Summary: The survey in Kongwa District found a TF prevalence of 7.1%, with 21.5% of TF-positive children testing positive for infection. Seropositivity was 18.2% on average, with children born after MDA cessation showing a seroprevalence of 6.7%, indicating exposure to C. trachomatis despite previous interventions.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Microbiology
Valentina A. Feodorova, Yury V. Saltykov, Anna A. Kolosova, Liudmila V. Rubanik, Nikolay N. Poleshchuk, Vladimir L. Motin
Summary: The study identified 12 different Chlamydia trachomatis sequence types (STs) among heterosexual chlamydia patients in seven regions of Belarus. The most common ST was ST4, followed by several other known and novel STs. The distribution of these STs varied across different regions. All detected CT strains were clustered into two groups characteristic of urogenital strains, and no STs specific to LGV strains were found.
Article
Microbiology
Laura Martinez-Garcia, Jose Maria Gonzalez-Alba, Teresa Puerta, Alicia Comunion, Maria Concepcion Rodriguez-Jimenez, Eva Orviz, Matilde Sanchez-Conde, Mario Rodriguez-Dominguez, Rafael Canton, Juan Carlos Galan
Summary: This study proposed a new combination of molecular markers based on the most variable genes of L-genotype genomes to improve the characterization of the current LGV epidemic in Madrid, Spain. The new combination of molecular markers demonstrated higher diversity and improved discrimination of LGV strains compared to the previously published MLST scheme based on hypervariable genes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Changchang Li, Weiming Tang, Hung Chak Ho, Jason J. Ong, Xiaojing Zheng, Xuewan Sun, Xia Li, Lijun Liu, Yajie Wang, Peizhen Zhao, Mingzhou Xiong, Heping Zheng, Cheng Wang, Bin Yang
Summary: The study found a high prevalence of Chlamydia trachomatis (CT) among childbearing-age women in China, with a significant proportion of cases being asymptomatic. Factors such as younger age at first sex, multiparous women, and having multiple sexual partners were associated with an increased risk of CT infection.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Microbiology
Hao Luo, Lihong Zeng, Xiaona Yin, Yuying Pan, Jianjiang Yang, Mingjing Liu, Xiaolin Qin, Zhanqin Feng, Wentao Chen, Heping Zheng
Summary: A CRISPR-based isothermal CT/NG dual-target detection system was developed, which demonstrated high sensitivity, excellent agreement with commercial assays, and greater convenience compared to PCR-based methods.
MICROBIOLOGY SPECTRUM
(2023)
Article
Immunology
Janet D. Wilson, Harriet E. Wallace, Michelle Loftus-Keeling, Helen Ward, Bethan Davies, Armando Vargas-Palacios, Claire Hulme, Mark H. Wilcox
Summary: Through comparing clinician triple samples and self-taken pooled samples, it was found that self-taken pooled samples have similar sensitivity to clinician triple samples in identifying Neisseria gonorrhoeae in men who have sex with men and females, but have a slight difference in identifying Chlamydia trachomatis infections. Extragenital sampling can be achieved at no additional diagnostic cost to first-catch urine and vulvovaginal swabs.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Microbiology
Paul C. Adamson, Jeffrey D. Klausner
Summary: Chlamydia trachomatis and Neisseria gonorrhoeae are two commonly reported bacterial infections in the United States, with the rectum and oropharynx being important sites of infection. Nucleic acid amplification tests are widely used for detection of these infections. However, routine screening for pharyngeal specimens is not recommended.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Immunology
Katariina Saarentausta, Lovisa Ivarsson, Susanne Jacobsson, Bjorn Herrmann, Martin Sundqvist, Magnus Unemo
Summary: The COVID-19 pandemic has had an impact on the incidence, epidemiology, and diagnostic testing of chlamydia and gonorrhoea in Sweden in 2020, with a significant decrease in cases compared to 2019. However, some regions in Sweden saw an increase in chlamydia cases. The use of internet-based self-sampling testing partially offset the decrease in attendance at STI clinics. Further studies are needed to fully understand the effects of COVID-19-related restrictions on sexual activity and STI incidence and epidemiology in Sweden.
Article
Microbiology
Adriana Bittencourt Campaner, Marco Antonio de Castro, Adrienne Pratti Lucarelli
Summary: A study conducted in a private health service in Sao Paulo, Brazil, found that Chlamydia trachomatis infection, the most prevalent sexually transmitted bacterial disease affecting the female reproductive system, is more common in young women, especially those under 25 and 30 years old. The study also revealed a significant increase in the positivity of test results over time, particularly in the age group under 35.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Chemistry, Medicinal
Luana Janaina de Campos, Mohamed A. . Seleem, Jiachen Feng, Kelly Mari Pires de Oliveira, Joao Victor de Andrade dos Santos, Shivdeep Hayer, Jonathan B. Clayton, Sharvath Kathi, Derek J. Fisher, Scot P. Ouellette, Martin Conda-Sheridan
Summary: Chlamydia trachomatis (CT) is the main cause of sexually transmitted bacterial disease in the United States. The lack of drug selectivity poses a challenge for current antichlamydial pharmacotherapy. By studying the disruption of CT-ClpXP by dihydrothiazepines, we synthesized a library of these compounds and evaluated their antichlamydial activity. We also demonstrated the inhibitory effect of our lead compound on ClpX ATPase activity and its promising selectivity, cytotoxicity, mutagenic potential, and in vitro stability. We generated a 2D QSAR model to aid in the identification of more potent antichlamydial molecules. This study suggests that dihydrothiazepines are a promising starting point for the development of selective antichlamydial drugs.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Infectious Diseases
Pierre-Edouard Fournier, Philippe Colson, Anthony Levasseur, Christian A. Devaux, Philippe Gautret, Marielle Bedotto, Jeremy Delerce, Ludivine Brechard, Lucile Pinault, Jean-Christophe Lagier, Florence Fenollar, Didier Raoult
Summary: In Marseille, France, a second wave of SARS-CoV-2 epidemic occurred from June, with the Marseille-4 variant being the major cause, carrying 13 hallmark mutations including one affecting the receptor binding domain of the spike protein. This variant has caused 2106 infections since September 2020 and is associated with a higher proportion of hypoxemia.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
Birgit Sadoghi, Birger Kraenke, Peter Komericki, Georg Hutterer
Summary: This mini-review provides the latest information and concepts on the diagnosis and treatment of common sexually transmitted pathogens causing urethritis. The incidence of sexually transmitted infections causing urethritis is increasing, and this genitourinary syndrome is a common reason why young men seek clinical care. The authors have conducted a literature search and developed a clinically applicable diagnostic and therapeutic algorithm. Future research will focus on developing new methods, including vaccination, to combat these pathogens.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Aditya Sharma, Gina Oda, Mark Holodniy
Summary: The effectiveness of mRNA-based vaccines following the emergence of the SARS-CoV-2 Omicron variant was evaluated. The study found that BNT162b2 and mRNA-1273 were effective against COVID-19, and a third dose provided additional protection over the primary series.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Yuan Tang, Xiaohan Yang, Lei Duan, Wenli Zhan, Keyi Chen, Huiying Chai, Pan Liu, Minchai Chen, Hongyu Zhao, Lihua Liang, Mengru Wei, Mingyong Luo
Summary: This study analyzed the genetic and clinical characteristics of genital Chlamydia trachomatis (CT) infection among women in Guangzhou, China. The major genotypes identified were J, E, F, and D, and they manifested as abnormal vaginal discharge, cervical columnar epithelial ectopy, vaginal itching, and lower abdominal pain.
INFECTION GENETICS AND EVOLUTION
(2022)
Article
Multidisciplinary Sciences
D. J. Darwin R. Bandoy, Bart C. Weimer
Summary: The study identified the speed and characteristics of the global spread of the novel coronavirus, proposing a method based on genomic variation and epidemiological data to predict increases in cases. By exploring differences in transmission between countries, researchers discovered variations in viral transmission dynamics across different nations and epidemic stages.
SCIENTIFIC REPORTS
(2021)
Article
Biochemical Research Methods
Rebecca L. Howard, David J. French, James A. Richardson, Colette E. O'Neill, Michael P. Andreou, Tom Brown, Duncan Clark, Ian N. Clarke, John W. Holloway, Peter Marsh, Paul G. Debenham
MOLECULAR AND CELLULAR PROBES
(2015)
Article
Infectious Diseases
Clare Labiran, Peter Marsh, Judith Zhou, Alan Bannister, Ian Nicholas Clarke, Stephanie Goubet, Suneeta Soni
SEXUALLY TRANSMITTED INFECTIONS
(2016)
Article
Multidisciplinary Sciences
Paul J. S. Skipp, Chris Hughes, Therese McKenna, Richard Edwards, James Langridge, Nicholas R. Thomson, Ian N. Clarke
Article
Multidisciplinary Sciences
Patiyan Andersson, Simon R. Harris, Helena M. B. Seth Smith, James Hadfield, Colette O'Neill, Lesley T. Cutcliffe, Fiona P. Douglas, L. Valerie Asche, John D. Mathews, Susan I. Hutton, Derek S. Sarovich, Steven Y. C. Tong, Ian N. Clarke, Nicholas R. Thomson, Philip M. Giffard
NATURE COMMUNICATIONS
(2016)
Article
Biochemistry & Molecular Biology
James Hadfield, Simon R. Harris, Helena M. B. Seth-Smith, Surendra Parmar, Patiyan Andersson, Philip M. Giffard, Julius Schachter, Jeanne Moncada, Louise Ellison, Maria Lucia Gallo Vaulet, Marcelo Rodriguez Fermepin, Frans Radebe, Suyapa Mendoza, Sander Ouburg, Servaas A. Morre, Konrad Sachse, Mirja Puolakkainen, Suvi J. Korhonen, Chris Sonnex, Rebecca Wiggins, Hamid Jalal, Tamara Brunelli, Patrizia Casprini, Rachel Pitt, Cathy Ison, Alevtina Savicheva, Elena Shipitsyna, Ronza Hadad, Laszlo Kari, Matthew J. Burton, David Mabey, Anthony W. Solomon, David Lewis, Peter Marsh, Magnus Unemo, Ian N. Clarke, Julian Parkhill, Nicholas R. Thomson
Article
Biochemical Research Methods
Catherine E. Winstanley, Kyle H. Ramsey, Peter Marsh, Ian N. Clarke
JOURNAL OF IMMUNOLOGICAL METHODS
(2017)
Article
Genetics & Heredity
A. R. Last, H. Pickering, C. H. Roberts, F. Coll, J. Phelan, S. E. Burr, E. Cassama, M. Nabicassa, H. M. B. Seth-Smith, J. Hadfield, L. T. Cutcliffe, I. N. Clarke, D. C. W. Mabey, R. L. Bailey, T. G. Clark, N. R. Thomson, M. J. Holland
Article
Immunology
K. H. Ramsey, J. H. Schripsema, B. J. Smith, Y. Wang, B. C. Jham, K. P. O'Hagan, N. R. Thomson, A. K. Murthy, R. J. Skilton, P. Chu, I. N. Clarke
INFECTION AND IMMUNITY
(2014)
Article
Multidisciplinary Sciences
Clare Labiran, David Rowen, Ian Nicholas Clarke, Peter Marsh
Article
Immunology
Colette Elizabeth O'Neill, Rachel Jane Skilton, Sarah Ann Pearson, Simone Filardo, Patiyan Andersson, Ian Nicholas Clarke
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2018)
Article
Microbiology
Kensuke Shima, Maximilian Wanker, Rachel J. Skilton, Lesley T. Cutcliffe, Christiane Schnee, Thomas A. Kohl, Stefan Niemann, Javier Geijo, Matthias Klinger, Peter Timms, Thomas Rattei, Konrad Sachse, Ian N. Clarke, Jan Rupp
Article
Multidisciplinary Sciences
Simone Filardo, Rachel J. Skilton, Colette E. O'Neill, Marisa Di Pietro, Rosa Sessa, Ian N. Clarke
SCIENTIFIC REPORTS
(2019)
Article
Microbiology
Charlotte A. Jones, James Hadfield, Nicholas R. Thomson, David W. Cleary, Peter Marsh, Ian N. Clarke, Colette E. O'Neill
Article
Multidisciplinary Sciences
Kolos V. Szabo, Colette E. O'Neill, Ian N. Clarke
Article
Multidisciplinary Sciences
Chloe Manning, Colette O'Neill, Ian N. Clarke, Monica Rebec, Penelope R. Cliff, Peter Marsh
Summary: This study conducted a research on the distribution of LGV MLVA-ompA genotypes among individuals attending GUM clinics in London. The study found that the L2 ompA genotype predominated in the London study population and detected an unusual hybrid L2b/D ompA profile previously reported in Portugal. Further monitoring and surveillance of LGV strains within the UK population is recommended.