Review
Biochemistry & Molecular Biology
Wenwen Wei, Xin Wang, Yuanzhong Zhou, Xuejun Shang, Hongsong Yu
Summary: Pregnancy-induced hypertension (PIH) is a severe pregnancy complication that can lead to maternal mortality. Various genetic factors have been shown to play an important role in the occurrence and development of PIH. This review summarizes the genetic risk factors involved in the renin-angiotensin system, endothelin system, inflammatory factors, oxidative stress, and other functional networks that may contribute to the pathogenesis of PIH.
Article
Genetics & Heredity
Jie Wei, Huan Zhang, Xiaoya Ma, Yujie Li, Wenqian Zhou, Jinping Guo, Tianbo Jin, Mingjun Hu
Summary: This study investigated the association between single nucleotide polymorphisms (SNPs) of the OR51E1 gene and glioma susceptibility in the Chinese Han population. The results showed that polymorphisms rs10768148, rs7102992, and rs10500608 were associated with glioma risk in the overall sample. Stratified analyses based on gender and age revealed specific SNP-glioma associations. Additionally, synergistic and redundant relationships between certain SNPs were identified. Overall, this study provides a basis for assessing glioma risk-associated variants in the Chinese Han population.
Article
Dentistry, Oral Surgery & Medicine
Minyan Yuan, Xueqing Zheng, Jiaojiao Jing, Yang Li, Nianke Liu, Yaling Song
Summary: This study evaluated the association between SYN2, PPARG, RAF1, TIMP4, and IQSEC1 polymorphisms in 3p25 and oral squamous cell carcinoma (OSCC) in the Chinese Han population. IQSEC1-rs2686742 was found to be correlated with the onset of OSCC, and several SNPs in IQSEC1 and PPARG genes were significantly associated with clinical characteristics of OSCC. IQSEC1-rs2600322 was shown to have an important role in the survival of OSCC patients, and various SNPs influenced survival outcomes. Functional annotation revealed changes in transcript levels of IQSEC1 and PPARG genes in OSCC tissues.
Article
Microbiology
Jelmer B. Jukema, Bernice M. Hoenderboom, Birgit H. B. van Benthem, Marianne A. B. Van der Sande, Henry J. C. de Vries, Christian J. P. A. Hoebe, Nicole H. T. M. Dukers-Muijrers, Caroline J. Bax, Servaas A. Morre, Sander Ouburg
Summary: Clear inter-individual differences in response to C. trachomatis infections exist, with certain genes' SNPs potentially influencing susceptibility and severity. NOD1 and IL10 gene SNPs may increase the risk of infection and late complications such as ectopic pregnancy or infertility. Further confirmatory studies on a larger scale are needed to explore the role of SNPs in CT infections.
Review
Genetics & Heredity
Li-Rong Yan, Zhi Lv, Jing-Jing Jing, Yuan Yuan, Qian Xu
Summary: Through meta-analysis, it was found that SNPs related to immune response are closely associated with AG risk, suggesting their potential as predictive biomarkers for AG. Further updated meta-analyses based on extensive relevant studies are needed for more reliable results.
Review
Oncology
Guanwu Wang, Lara Rosaline Heij, Dong Liu, Edgar Dahl, Sven Arke Lang, Tom Florian Ulmer, Tom Luedde, Ulf Peter Neumann, Jan Bednarsch
Summary: This systematic review evaluated the association between single-nucleotide polymorphisms (SNPs) and cholangiocarcinoma (CCA), focusing on tumorigenesis and prognosis. Based on 34 studies, a total of 43 SNPs in 32 genes associated with CCA risk, metastatic progression, and overall prognosis were identified. The study comprehensively described the mechanisms and potential clinical implications associated with these SNPs. The findings suggest that multiple SNPs play different roles at different stages of CCA and may serve as biomarkers for guiding treatment and assessing oncological risk.
Article
Biochemistry & Molecular Biology
Hanyi Zhang, Siyao Deng, Jiayu Zhang, Guiquan Zhu, Jie Zhou, Wenjing Ye, Qingwei Wang, Yi Wang, Bingwen Zou, Peng Zhang, Shichuan Zhang, Jinyi Lang, Shun Lu
Summary: Genetic variants in genes involved in the LMP1 signaling pathway, particularly the NFKBIA promoter SNP rs2233409, may be moderately associated with the risk of nasopharyngeal carcinoma (NPC). Further studies with larger sample sizes and functional analysis are needed to confirm these findings.
Article
Oncology
Zheng Lv, Changgui Kou, Naifei Chen, Lin Jia, Xu Sun, Yangyang Gao, Rilan Bai, Ming Yang, Jiuwei Cui
Summary: This study indicates that HOTAIR SNPs (rs920778 and rs4759314) are significantly associated with BC susceptibility and prognosis in the northeastern Chinese population, highlighting their importance in the occurrence and development of BC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Sarah E. Kralicek, Lalitha M. Sitaraman, Paulius V. Kuprys, Amanda T. Harrington, Bharat Ramakrishna, Majdi Osman, Gail A. Hecht
Summary: This study defines the clinical manifestations of sporadic aEPEC infection in children and adults in the United States for the first time. It shows that aEPEC can cause a range of symptoms, from asymptomatic carriage to severe diarrhea. Higher EPEC load is associated with the presence of symptoms, but it does not predict disease severity.
Article
Biochemistry & Molecular Biology
Na Li, Zhigang Cui, Min Gao, Sixuan Li, Mingyang Song, Ying Wang, Lianwei Tong, Yanhong Bi, Ziwei Zhang, Shengli Wang, Baosen Zhou, Zhihua Yin
Summary: rs13252298 and rs1456315 in PRNCR1 may be genetic susceptibility factors for lung cancer in Chinese population. These results need to be confirmed by further studies.
DNA AND CELL BIOLOGY
(2021)
Article
Infectious Diseases
Ming-Gui Wang, Jing Wang, Jian-Qing He
Summary: This study found a significant association between two SNPs (rs5743867 and rs5743899) in the TOLLIP gene and susceptibility to HIV infection in a Chinese Han population. No significant association was found between MBL2 gene polymorphisms and HIV infection.
BMC INFECTIOUS DISEASES
(2021)
Article
Biotechnology & Applied Microbiology
Dennis N. Lozada, Madhav Bhatta, Danise Coon, Paul W. Bosland
Summary: Genetic diversity among New Mexican chile peppers was assessed using GBS-derived SNP markers, revealing genetic relatedness among different populations. Introducing novel alleles from other breeding programs or wild species could help increase diversity in the current germplasm. Valuable information for future association mapping and genomic selection for genetic improvement through marker-assisted breeding in New Mexican chile peppers was presented.
Article
Oncology
Yihan Cui, Wenjin Wang, Peipei Luo, Yun Feng, Chen Mi, Ai Jia
Summary: This study found that SP4 gene polymorphisms are associated with gastric cancer risk, and specific genotypes may reduce the risk of gastric cancer.
Article
Immunology
Javier Martinez-Sanz, Daniel Jimenez, Laura Martinez-Campelo, Raquel Cruz, Pilar Vizcarra, Matilde Sanchez-Conde, Raquel Ron, Mario Rodriguez, Sabina Herrera, Santiago Moreno, Maria Rosa Lopez-Huertas, Sergio Serrano-Villar
Summary: The study found two genetic variants that may increase the risk of individuals being susceptible to SARS-CoV-2, aiding in identifying vulnerable populations and suggesting treatment targets for COVID-19 patients.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Biochemistry & Molecular Biology
Lan-Ting Yuan, Yi-Chieh Yang, Hsiang-Lin Lee, Pei-Chun Shih, Li-Hsin Chen, Chih-Hsin Tang, Lun-Ching Chang, Hsiang-Ling Wang, Shun-Fa Yang, Ming-Hsien Chien
Summary: The genetic variant rs9914618 of the LINC00673 gene may serve as a promising biomarker for hepatocellular carcinoma (HCC), especially in elderly populations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Cynthia L. Chappell, Pablo C. Okhuysen, Rebecca C. Langer-Curry, Philip J. Lupo, Giovanni Widmer, Saul Tzipori
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2015)
Article
Biotechnology & Applied Microbiology
Charles Darkoh, Cynthia Chappell, Christopher Gonzales, Pablo Okhuysen
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2015)
Article
Medicine, General & Internal
Amanda Mocroft, Jens D. Lundgren, Michael Ross, Matthew Law, Peter Reiss, Ole Kirk, Colette Smith, Deborah Wentworth, Jacqueline Neuhaus, Christoph A. Fux, Olivier Moranne, Phillipe Morlat, Margaret A. Johnson, Lene Ryom
Article
Gastroenterology & Hepatology
Parag Mahale, Pablo C. Okhuysen, Harrys A. Torres
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2014)
Article
Public, Environmental & Occupational Health
Nadim J. Ajami, Owen V. Kavanagh, Sasirekha Ramani, Sue E. Crawford, Robert L. Atmar, Zhi-Dong Jiang, Pablo C. Okhuysen, Mary K. Estes, Herbert L. DuPont
JOURNAL OF TRAVEL MEDICINE
(2014)
Article
Public, Environmental & Occupational Health
Parvathy Nair, Pablo C. Okhuysen, Zhi-Dong Jiang, Lily G. Carlin, Jaime Belkind-Gerson, Jose Flores, Mercedes Paredes, Herbert L. DuPont
JOURNAL OF TRAVEL MEDICINE
(2014)
Article
Infectious Diseases
Alberto Matteelli, Patricia Schlagenhauf, Anna C. C. Carvalho, Leisa Weld, Xiaohong M. Davis, Annelies Wilder-Smith, Elizabeth D. Barnett, Philippe Parola, Prativa Pandey, Pauline Han, Francesco Castelli
LANCET INFECTIOUS DISEASES
(2013)
Letter
Medicine, General & Internal
Miguel M. Cabada, Pablo C. Okhuysen, A. Clinton White
NEW ENGLAND JOURNAL OF MEDICINE
(2013)
Article
Multidisciplinary Sciences
Alvaro H. Borges, Jemma L. O'Connor, Andrew N. Phillips, Jason V. Baker, Michael J. Vjecha, Marcelo H. Losso, Hartwig Klinker, Gustavo Lopardo, Ian Williams, Jens D. Lundgren
Article
Cardiac & Cardiovascular Systems
Anna D. Nordell, Matthew McKenna, Alvaro H. Borges, Daniel Duprez, Jacqueline Neuhaus, James D. Neaton
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2014)
Article
Immunology
Eduardo A. Yepez Guevara, Samuel L. Aitken, Adilene Olvera, Lily Carlin, Kerri E. Fernandes, Micah M. Bhatti, Kevin W. Garey, Javier Adachi, Pablo C. Okhuysen
Summary: This study investigated Clostridioides difficile infection in cancer patients, finding that patients with EIA+ were older, more likely to fail therapy and experience recurrence, with the presence of ribotypes associated with poor outcomes increasing the risk of treatment failure.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Virology
Guy Handley, Rodrigo Hasbun, Pablo Okhuysen
Summary: This study reviewed HHV-6 CNS infection in patients admitted to MD Anderson Cancer Center between March 2016 and December 2018. Among 725 patients tested for HHV-6, 19 cases (2.6%) of HHV-6 mediated CNS disease were identified, with most patients being HSCT recipients. Survival rate at 240 days post-transplant was 62%. The study also found that significant diagnostic discordance exists between testing platforms, and HHV-6 reactivation leading to CNS disease can also occur in patients receiving CAR T-cell therapy or biologic immunotherapy.
JOURNAL OF CLINICAL VIROLOGY
(2021)
Review
Immunology
Divya Samantha Kondapi, Sasirekha Ramani, Mary K. Estes, Robert L. Atmar, Pablo C. Okhuysen
Summary: Norovirus is the leading cause of viral-related diarrhea in cancer patients, with immunosuppressed patients shedding the virus for longer periods. Challenges in diagnosis and treatment of Norovirus infection in cancer patients exist, with potential treatments including screening for inhibitors and developing specific T cells.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Biology
Vipin K. Menon, Pablo C. Okhuysen, Cynthia L. Chappell, Medhat Mahmoud, Medhat Mahmoud, Qingchang Meng, Harsha Doddapaneni, Vanesa Vee, Yi Han, Sejal Salvi, Sravya Bhamidipati, Kavya Kottapalli, George Weissenberger, Hua Shen, Matthew C. Ross, Kristi L. Hoffman, Sara Javornik Cregeen, Donna M. Muzny, Ginger A. Metcalf, Richard A. Gibbs, Joseph F. Petrosino, Fritz J. Sedlazeck
Summary: This study provides a highly accurate and complete reference genome of Cryptosporidium parvum, based on Oxford Nanopore reads and improved using Illumina reads. The assembly includes 8 chromosomes and resolves 13 telomeres, with a high completion rate of 98.4% single-copy BUSCO genes. This high-quality reference genome will facilitate future comparative genomic studies across the Cryptosporidium clade.
Letter
Medicine, General & Internal
Allen G. P. Ross, Allan W. Cripps
NEW ENGLAND JOURNAL OF MEDICINE
(2013)