期刊
CURRENT OPINION IN IMMUNOLOGY
卷 25, 期 6, 页码 728-735出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2013.09.018
关键词
-
类别
资金
- NIH [U01 AI101981, R21 AI61479, U19 AI50864, R01 AR051394]
- Rheumatology Research Foundation
Clinical manifestations of rheumatoid arthritis (RA), the second most common human autoimmune disease, are primarily focused on the joints, causing disability and requiring life-long treatment to ameliorate signs and symptoms. The etiology of RA is unknown; however, important discoveries in two areas have been made which provide hope that the causal mechanisms can be identified. First, the most severe form of this disease is associated with the presence of humoral and cellular autoimmunity to citrullinated proteins and peptides. Second, in the natural history of RA, autoimmunity to citrullinated antigens appears years before the onset of clinically apparent disease. Herein is described a model in which to consider how these two features are linked during very early disease development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据