Review
Biochemistry & Molecular Biology
Laura Passeri, Fortunato Marta, Virginia Bassi, Silvia Gregori
Summary: Dendritic cells play a crucial role in autoimmune diseases by instructing T cells to respond to antigens, leading to organ damage or promoting immune tolerance. Research on different subsets of human DCs and the regulatory mechanisms associated with tolDC functions is ongoing, along with exploring tolDC-based therapies for treating autoimmune diseases. Continued expansion of research in the area of tolDCs will enhance understanding of the role of DCs in the development and treatment of autoimmunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Nick Giannoukakis
Summary: Tolerogenic dendritic cells (tDC) have the potential to prevent the progression of autoimmune-driven dysglycemia into insulin-requiring type 1 diabetes (T1D) and preserve β cells. tDC act via multiple layers of immune regulation to suppress effector lymphocytes targeting β cells. It is now appropriate to conduct phase II clinical trials for T1D using well-characterized tDC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xianmei Liu, Peng Yu, Yujun Xu, Yun Wang, Jin Chen, Fuzhou Tang, Zuquan Hu, Jing Zhou, Lina Liu, Wei Qiu, Yuannong Ye, Yi Jia, Weijuan Yao, Jinhua Long, Zhu Zeng
Summary: Dendritic cells (DCs) can mediate immune responses or immune tolerance depending on their immunophenotype and functional status. Metformin can induce tolerance in DCs by reprogramming their metabolic patterns, thereby exerting anti-inflammatory effects.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Immunology
Ruoyu Li, Hui Li, Xiaoyan Yang, Huiru Hu, Peidong Liu, Hongbo Liu
Summary: This review summarizes the interaction and protective mechanisms between dendritic cells (DCs) and regulatory T cells (Tregs) in multiple sclerosis (MS), explores their potential value in the treatment of MS, and proposes new therapeutic directions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Farhan Ullah Khan, Puregmaa Khongorzul, Ahmed Aziz Raki, Ashwini Rajasekaran, Denis Gris, Abdelaziz Amrani
Summary: Type 1 diabetes is caused by the destruction of pancreatic beta cells mediated by T cells. Dendritic cells play a crucial role in the initiation and development of this disease by presenting antigens to activate and regulate the immune response. Recent advancements in understanding dendritic cell function and regulation have led to the development of potential therapeutic strategies for treating type 1 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Yifeng Liu, Xiaoze Wang, Fan Yang, Yanyi Zheng, Tinghong Ye, Li Yang
Summary: Dendritic cells play a crucial role in bridging innate immunity and adaptive immunity by regulating immune responses and providing co-stimulatory molecules and cytokines. Non-coding RNAs participate in the pathological mechanisms of autoimmune diseases and their dysregulation affects the differentiation and functions of dendritic cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Henner Zirpel, Bart O. Roep
Summary: Type 1 diabetes is believed to be caused by autoimmune attack on insulin-producing β-cells, triggered by immune system errors. Islet-resident macrophages and dendritic cells play a crucial role in the onset and development of T1D by linking stressed β-cells with activation of the adaptive immune system. Understanding the interaction between β-cells and innate immune cells can offer new insights into disease initiation and potential treatment options.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Guojiao Lin, Jialiang Wang, Yong-Guang Yang, Yuning Zhang, Tianmeng Sun
Summary: This paper reviews the research progress on how nano-delivery systems can be modulated for targeted delivery to dendritic cells and induce immune tolerance.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Kelly R. Rhodes, Stephany Y. Tzeng, Marcos Iglesias, Dongwoo Lee, Kaitlyn Storm, Sarah Y. Neshat, Derek VanDyke, Shirley M. Lowmaster, Jamie B. Spangler, Giorgio Raimondi, Jordan J. Green
Summary: Multiple sclerosis (MS) is an autoimmune disease where immune cells damage myelinated nerves, resulting in impaired brain function. We developed a therapy using biodegradable microparticles loaded with rapamycin, an interleukin-2 fusion protein, and a myelin peptide to promote Treg expansion and activity. This therapy showed promising results in a mouse model of MS.
Review
Immunology
Aikaterini Hatzioannou, Athina Boumpas, Miranta Papadopoulou, Iosif Papafragkos, Athina Varveri, Themis Alissafi, Panayotis Verginis
Summary: Treg cell plasticity plays a significant role in autoimmunity and cancer, characterized by loss of Foxp3 expression. It has great therapeutic potential through destabilizing Treg cells to promote anti-tumor immunity or enhancing Treg cell stability to attenuate chronic inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Jorge Postigo-Fernandez, Rebuma Firdessa-Fite, Remi J. Creusota
Summary: Antigen-specific immunotherapy using tailored epitopes delivered through proteins, peptides, or nucleic acids can reestablish tolerance and potentially provide precision medicine approach for treating tissue-specific autoimmune diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Immunology
Caiyun Liu, Jie Zhu, Yan Mi, Tao Jin
Summary: Dendritic cells (DCs) play a crucial role in autoimmune diseases such as multiple sclerosis (MS) and can be significantly affected by current disease-modifying therapies (DMT). The induction of tolerogenic DCs (tolDCs) has shown therapeutic potential in laboratory models and early clinical trials. Targeting specific cell-surface receptors to induce tolDCs in vivo has greater promise and advantages compared to in vitro induction.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Mohammad Reza Javan, Azam Rahimpour, Seyed Mohammad Moazzeni
Summary: Simultaneous overexpression of A20 and BTLA genes in DCs resulted in the development of tolerogenic DCs with enhanced potential in inducing Treg cells. These DCs showed remarkable stability after inflammatory stimulation, offering a promising potential in treating autoimmune and inflammatory disorders.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Chun Zhang, Xiuxing Liu, Jing Xiao, Fanwen Jiang, Luzhong Fa, Hui Jiang, Lin Zhou, Wenru Su, Zhuping Xu
Summary: Autoimmune uveitis is a non-infectious, inflammatory intraocular disease that affects the uveal and adjacent tissues, leading to visual loss. Activated γδ T cells play a significant role in the development of autoimmune uveitis by secreting pro-inflammatory factors and promoting Th17 cell responses. Understanding the mechanisms of γδ T cell involvement in different activation and disease states provides insights for the development of immunotherapies for treating autoimmune uveitis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Immunology
Jinwen Lin, Hongyi Wang, Chenxi Liu, Ao Cheng, Qingwei Deng, Huijuan Zhu, Jianghua Chen
Summary: Dendritic cells play a crucial role in inducing and regulating adaptive immunity in the kidney, with different phenotypes having varying effects such as promoting rejection or suppressing inflammation and damage. These cells interact with effector T cells and regulatory T cells, but the classification and effects of different subsets are still controversial.
FRONTIERS IN IMMUNOLOGY
(2021)