期刊
CURRENT OPINION IN IMMUNOLOGY
卷 23, 期 2, 页码 258-264出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.12.014
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资金
- Medical Research Council
- Cancer Research UK
- Leukaemia & Lymphoma Research
- Gregor MacKay Memorial Fund
- Medical Research Council [G0901755, G0801936, G9818340B] Funding Source: researchfish
- MRC [G0901755, G0801936] Funding Source: UKRI
Epstein-Barr virus (EBV), a B-lymphotropic herpesvirus widespread in the human population and normally contained as an asymptomatic infection by T cell surveillance, nevertheless causes infectious mononucleosis and is strongly linked to several types of human cancer. Here we describe new findings on the range of cellular immune responses induced by EBV infection, on viral strategies to evade those responses and on the links between HLA gene loci and EBV-induced disease. The success of adoptive T cell therapy for EBV-driven post-transplant lymphoproliferative disease is stimulating efforts to target other EBV-associated tumours by immunotherapeutic means, and has reawakened interest in the ultimate intervention strategy, a prophylactic EBV vaccine.
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