期刊
CURRENT OPINION IN IMMUNOLOGY
卷 23, 期 2, 页码 163-170出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.11.014
关键词
-
类别
资金
- NIH [R01 AI079047]
- NSF/Alfred P. Sloan Foundation
The progression of hematopoietic stem cells (HSCs) to the B lymphocyte lineage requires that uncommitted progenitors successfully negotiate the transition from multipotency to unipotency, including the loss of self-renewal potential. Previous work identified essential transcription factors that mediate B lineage development. Major advances build on this knowledge and reveal coordinated changes in gene expression occurring within single cells at sequential stages in the B cell differentiation pathway. Recent studies on epigenetic mechanisms also provide a framework within which transcription factor activity, chromatin modifications, and gene expression patterns can be viewed at hierarchical levels to link genotype and phenotype.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据