期刊
CURRENT OPINION IN IMMUNOLOGY
卷 22, 期 3, 页码 367-373出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.04.001
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资金
- [6000.RAD1.F.A0309]
Although significant progress has been made in clinical development, a protective malaria vaccine remains elusive. Here we review some of the immune subversive mechanisms used by the Plasmodium malaria parasite and propose a potentially effective strategy to achieve complete protection that may serve as a blue print for clinical usage. The premise is to modulate the immune response with drugs that neutralize suppressive functions and potentiate protective responses. Chloroquine may be a first attractive candidate facilitating protective cellular immune responses by improving cross-presentation and reducing suppressive regulatory T cell responses.
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