期刊
CURRENT OPINION IN IMMUNOLOGY
卷 22, 期 1, 页码 131-136出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2009.12.007
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资金
- Crohn's and Colitis Foundation of America (CCFA)
- European Research Council (ERC)
- European Commission [FP7]
- Italian Association for Cancer Research (AIRC)
Recent advances have highlighted that antigen presentation in the gastrointestinal tract is carried out by different specialized immune and non-immune cells. This is required in order to achieve tolerance towards self and non-self harmless antigens and immunity towards pathogenic microorganisms. In this review we will discuss the role of different players in these responses, including dendritic cells, macrophages, B cells and basophils as professional antigen presenting cells (APCs), and stromal cells and epithelial cells as non-professional APCs. The interaction between these cell types is required for the dynamic regulation of the immune response.
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