Review
Immunology
Mariela Jimenez, Daniel Cervantes-Garcia, Laura E. Cordova-Davalos, Marian Jesabel Perez-Rodriguez, Claudia Gonzalez-Espinosa, Eva Salinas
Summary: Mast cells are immune cells strategically located in tissues close to the external environment, playing a key role in the host defense against invading pathogens. They release biologically active mediators to induce inflammation, promote antimicrobial activities, and shape innate and adaptive immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Cheng Wang, Yajing Hou, Shuai Ge, Jiayu Lu, Xiangjun Wang, Yuexin Lv, Nan Wang, Huaizhen He
Summary: This study demonstrates for the first time that synthetic imperatorin derivatives are effective in inhibiting MRGPRX2-induced allergic reactions and exhibit anti-allergic properties in a mouse model. These findings provide evidence for the development of drugs for the treatment of allergic diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Food Science & Technology
Mehtap Civelek, Sabrina Bilotta, Axel Lorentz
Summary: This review summarizes the anti-inflammatory effects of resveratrol on mast cell-mediated allergic reactions. The studies suggest that resveratrol can inhibit mast cell degranulation and the release of proinflammatory mediators, and has positive impacts on allergic rhinitis patients. However, strategies to improve resveratrol's bioavailability need to be developed.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Immunology
Xin Liu, Yufei Zhang, Xu Cui, Ting Fan, Jin Shu, Hui Li, Xiaojing Huo, Chao Lu
Summary: Gd-DTPA induced severe allergic reactions and mast cells activation, leading to histamine, tryptase, and cytokines release in both mice serum and LAD2 cells supernatant. RNAseq analysis showed changes in mRNA levels related to inflammation signaling pathways after Gd-DTPA activated MCs.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Subhadip Choudhuri, Imran Hussain Chowdhury, Nisha Jain Garg
Summary: Innate immune cells, such as macrophages, serve as the first line of defense against pathogens. Pathogen invasion can impact mitochondrial metabolism in macrophages, influencing their response against pathogens. Mitophagy plays a critical role in regulating macrophage activation by removing damaged mitochondria.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Feng Yuan, Chi Zhang, Maji Sun, Dongying Wu, Lin Cheng, Bin Pan, Ting Li, Delu Che
Summary: The study showed that Iohexol induces immediate-type pseudo-allergic reactions via MRGPRX2-mediated activation of mast cells. Structural modifications can reduce the effects of Iohexol-induced reactions, highlighting the importance of preventing allergic reactions to Iohexol.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biology
Jin Wang, Jiayi Xie, Daosong Wang, Xue Han, Minqi Chen, Guojun Shi, Linjia Jiang, Meng Zhao
Summary: Using single-cell sequencing, researchers identified a specific subpopulation of megakaryocytes (MKs) that highly expressed CXCR4 and exhibited both immune characteristics and MK-specific features. These CXCR4(high) MKs interacted with myeloid cells to promote their migration and enhance bacterial phagocytosis, and they were also capable of antigen presentation to activate T cells. Furthermore, in response to bacterial infection, these CXCR4(high) MKs could exit circulation and infiltrate into the spleen, liver, and lung. The ablation of MKs suppressed the innate immune response and impaired the anti-bacterial effects of T cells in mice.
Article
Immunology
Caijie Zhou, Meihua Li, Yu Liu, Xinxin Wang, Shuang Zhang, Li Guan, Jingyi Hong, Wei Zhou, Gaohui Wu, Weiliang Diao, Qinmiao Huang, Pingchang Yang
Summary: TAFA4 can suppress the expression of FcεRI in mast cells to attenuate experimental AR. It is negatively correlated with tryptase levels in nasal secretions and modulates the transcription of Fcer1g gene.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Plant Sciences
Yuanyuan Ding, Yuejin Wang, Chaomei Li, Yongjing Zhang, Shiling Hu, Jiapan Gao, Rui Liu, Hongli An
Summary: The study demonstrated that ALA has inhibitory effects on allergic reactions both in vitroand in vivo by reducing histamine levels, vasodilation, and mast cell degranulation through Lyn-PLC gamma-IP3R-Ca2+ and Lyn-p38/NF-kappa B signaling pathway. Moreover, ALA acts as a potential Lyn kinase inhibitor, providing a possible treatment option for pseudo-allergic reactions like urticaria.
Article
Multidisciplinary Sciences
Hong Bing Yu, Hyungjun Yang, Joannie M. Allaire, Caixia Ma, Franziska A. Graef, Arthur Mortha, Qiaochu Liang, Else S. Bosman, Gregor S. Reid, James A. Waschek, Lisa C. Osborne, Harry Sokol, Bruce A. Vallance, Kevan Jacobson
Summary: The research shows that VIP promotes the recruitment of ILC3 to the intestine through VPAC1, and is essential for the postnatal formation of lymphoid tissues and the maintenance of RA-producing dendritic cells. Lack of VIP or VPAC1 results in a paucity of ILC3 in the intestine, making mice highly susceptible to C. rodentium infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Ishita Tripathi-Giesgen, Christian Behrends, Arno F. Alpi
Summary: The ubiquitin system plays a crucial role in the host cellular defense program against bacterial infection, especially when certain bacteria are exposed to the host cytosol during invasion. Host cell E3 ubiquitin ligases contribute to the formation of a protective ubiquitin coat on invading pathogens, with their divergent ubiquitin conjugation mechanisms influencing the complexity of the anti-bacterial coating. Bacteria have evolved strategies to evade the activities of the host ubiquitin system.
Article
Immunology
Hee-Yun Kim, Hanchul Jung, Hyung-Min Kim, Hyun-Ja Jeong
Summary: Surfactin exhibits significant anti-cancer effects on melanoma skin cancer by enhancing immune response and inducing apoptosis of melanoma cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lucia Garcia-Garcia, Laia Olle, Margarita Martin, Jordi Roca-Ferrer, Rosa Munoz-Cano
Summary: Adenosine, through its binding to different G protein-coupled receptors, can have either anti-inflammatory or pro-inflammatory effects, with A2a receptor typically showing anti-inflammatory activity. Understanding the mechanisms of action of adenosine on specific receptors may lead to the development of more effective therapies for allergic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Zhongwei Zhang, Peter B. Ernst, Hiroshi Kiyono, Yosuke Kurashima
Summary: Mast cells are widely distributed immune cells with diverse phenotypes and functions. They exhibit high functional heterogeneity and plasticity due to their unique maturation mechanism. Mast cells can adapt to different microenvironments and regulate allergy and inflammation under the peripheral immune education system. This review focuses on the mechanism and heterogeneity of mast cell migration to mucosal tissues, such as the gastrointestinal tract. The immunosuppressive properties of mast cells suggest a potential new approach for treating inflammatory and allergic disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yara Zoabi, Francesca Levi-Schaffer, Ron Eliashar
Summary: Allergic rhinitis is a common nasal disorder affecting up to 30% of adults. Mast cells play a crucial role in allergic inflammation and are involved in the development of symptoms. This review provides a comprehensive summary of mast cells' involvement in allergic rhinitis and the modulation of mast cells by current and emerging therapies.