期刊
CURRENT OPINION IN HEMATOLOGY
卷 21, 期 5, 页码 410-417出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOH.0000000000000070
关键词
hemostasis; in-vivo models; platelets; systems biology; thrombosis
类别
资金
- American Heart Association [11SDG5720011]
- National Heart, Lung and Blood Institute [R01 HL119070, P01 HL40387, R01 HL103419]
- NHLBI [T32-HL07439]
Purpose of review Several decades of work by many investigators have elucidated the major signaling pathways responsible for platelet activation. Still to be fully understood is how these pathways are integrated into a single network and how changing conditions within a growing thrombus affect that network. In this review we will consider some of the recent studies that address these issues and describe a model that provides insights into platelet activation as it occurs in vivo. Recent findings Genetic and pharmacologic studies performed in vivo have demonstrated that platelet activation during hemostasis and thrombosis is heterogeneous. Those studies indicate that distinct platelet activation pathways are not merely redundant, but are coordinated in time and space to achieve an optimal response. This coordination is achieved at least in part by the evolving distribution of platelet agonists and changes in solute transport within a hemostatic plug. Summary Studies examining the coordination of platelet signaling in time and space continue to increase our understanding of hemostasis and thrombosis. In addition to helping to decipher platelet biology, the results have implications for the understanding of new and existing antiplatelet agents and their potential risks.
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