期刊
JOURNAL OF NEUROSCIENCE
卷 35, 期 16, 页码 6298-6306出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4561-14.2015
关键词
action value; dorsal striatum; neuromodulation; Parkinson's disease; reinforcement learning; sequential decision making
资金
- Brain Research Trust
- Wellcome Trust
- Intramural Research Program of the National Institute of Mental Health
Decisions are often driven by a combination of immediate perception and previous experience. In this study, we investigated how these two sources of information are integrated and the neural systems that mediate this process. Specifically, we injected a dopamine type 1 antagonist (D1A; SCH23390) or a dopamine type 2 antagonist (D2A; eticlopride) into the dorsal striatum while macaques performed a task in which their choices were driven by perceptual inference and/or reinforcement of past choices. We found that the D2A affected choices based on previous outcomes. However, there were no effects of the D2A on choices driven by perceptual inference. We found that the D1A did not affect perceptual inference or reinforcement learning. Finally, a Bayesian model applied to the results suggested that the D2A may be increasing noise in the striatal representation of value, perhaps by disrupting the striatal population that normally represents value.
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