期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 25, 期 -, 页码 131-137出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2013.11.009
关键词
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资金
- National Institutes of Health under Ruth L Kirschstein National Research Service Award [CA168263-01A1]
- National Cancer Institute (JMD)
- NIH [HG002668]
The structural maintenance of chromosomes (SMC) complexes are associated with transcriptional enhancers, promoters and insulators, where they contribute to the control of gene expression and genome structure. We review here recent insights into the interlinked roles of SMC complexes in gene expression and genome architecture. Among these, we note evidence that SMC complexes play important roles in the regulation of genes that control cell identity. We conclude by reviewing diseases associated with SMC mutations.
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