期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 27, 期 -, 页码 92-101出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2014.05.002
关键词
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资金
- NIH [P01 GM099134]
- CIRM [RB3-05080, RB4-06133]
- Jonsson Comprehensive Cancer Center
- Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA
- CIRM
- UCLA Graduate Division
- Whitcome Pre-doctoral Training Program
The organization of chromatin within the nucleus and the regulation of transcription are tightly linked. Recently, mechanisms underlying this relationship have been uncovered. By defining the organizational hierarchy of the genome, determining changes in chromatin organization associated with changes in cell identity, and describing chromatin organization within the context of linear genomic features (such as chromatin modifications and transcription factor binding) and architectural proteins (including Cohesin, CTCF, and Mediator), a new paradigm in genome biology was established wherein genomes are organized around gene regulatory factors that govern cell identity. As such, chromatin organization plays a central role in establishing and maintaining cell state during development, with gene regulation and genome organization being mutually dependent effectors of cell identity.
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