期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 21, 期 6, 页码 740-746出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2011.09.007
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资金
- NIGMS NIH HHS [R01 GM062300, R01 GM062300-11] Funding Source: Medline
Cell polarity is typically oriented by external cues such as cell-cell contacts, chemoattractants, or morphogen gradients. In the absence of such cues, however, many cells can spontaneously polarize in a random direction, suggesting the existence of an internal polarity-generating mechanism whose direction can be spatially biased by external cues. Spontaneous 'symmetry-breaking' polarization is likely to involve an autocatalytic process set off by small random fluctuations [1]. Here we review recent work on the nature of the autocatalytic process in budding yeast and on the question of why polarized cells only develop a single 'front'.
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