期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 18, 期 3, 页码 264-272出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2008.07.004
关键词
-
资金
- MRC [MC_U127527199] Funding Source: UKRI
- Medical Research Council [MC_U127527199] Funding Source: Medline
The nature-nurture argument surrounding the mechanisms of disease causation cannot be resolved, as the roles of genes and environment are inextricably entwined. Environmental fluctuation is clearly a major modifier of phenotype, as well as a promoter of evolutionary change. Both types of variability can be mediated by the stress response pathway, with the Hsp90 chaperone family as key components. Hsp90 has been hailed as a capacitor for evolutionary change, because partial inhibition of its functions can uncover cryptic mutations, leading to unexpected phenotypes that, although generally deleterious, will under rare new environmental conditions provide improved survival to the carrier of that variant. There is, therefore, a strong environmentally elicited link between the capacity to reveal hidden variation as human disease phenotype and as novel morphological forms for evolutionary selection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据