期刊
CURRENT OPINION IN GASTROENTEROLOGY
卷 29, 期 3, 页码 299-304出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOG.0b013e32835f3f14
关键词
apoptosis; bile acids; choleresis; G-protein-coupled receptor; proliferation
资金
- Deutsche Forschungsgemeinschaft through Sonderforschungsbereich 575 Dusseldorf
- Sonderforschungsbereich 974 Dusseldorf
- Klinische Forschergruppe 217 'Hepatobiliary Transport'
Purpose of review TGR5 (Gpbar-1) is an emerging drug target for metabolic, intestinal and liver diseases. In liver, the highest expression of TGR5 is found in biliary epithelial cells. This review focusses on the function of TGR5 in cholangiocytes and the potential role of the receptor in biliary diseases. Recent findings TGR5 is localized in the primary cilium and the apical membrane domain of cholangiocytes, where the receptor exerts secretory, proliferative and antiapoptotic effects. Recent human and animal studies using bile acid analogues suggest a therapeutic potential for TGR5 in primary biliary cirrhosis but not in primary sclerosing cholangitis. Summary TGR5 has protective functions in cholangiocytes. Further studies are needed to determine the therapeutic potential of TGR5 agonists and antagonists in biliary diseases.
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