Article
Microbiology
Ying-Shu Liao, Bo-Han Chen, Ru-Hsiou Teng, You-Wun Wang, Jui-Hsien Chang, Shiu-Yun Liang, Chi-Sen Tsao, Yu-Ping Hong, Hui-Yung Sung, Chien-Shun Chiou
Summary: Research in Taiwan has shown that C. coli and C. jejuni are highly resistant to most therapeutic antimicrobials. Whole-genome sequencing was used to analyze genetic diversity among isolates and genetic resistance determinants associated with antimicrobial resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Rozan O. Al-Khresieh, Hala Al-Daghistani, Saeid M. Abu-Romman, Lubna F. Abu-Niaaj
Summary: This study investigates the link between human campylobacteriosis and the consumption of potentially contaminated food, finding that chicken meat is the main source of infection. The colonization rate of Campylobacter jejuni in chickens is influenced by the slaughterhouse environment, and antibiotic resistance is widespread among Campylobacter strains.
Article
Gastroenterology & Hepatology
Bilal Djeghout, Samuel J. Bloomfield, Steven Rudder, Ngozi Elumogo, Alison E. Mather, John Wain, Nicol Janecko
Summary: This study investigated the genomic diversity of Campylobacter jejuni within individual stool specimens from four campylobacteriosis patients. The findings show that the C. jejuni population recovered from an individual patient's stool are genetically diverse even within the same sequence type, indicating that patients were likely infected with a heterogeneous C. jejuni population. The diversity of the C. jejuni population found within individual stool specimens can inform future methodological approaches to attribution and outbreak investigations.
Article
Chemistry, Medicinal
Richard A. Stein
Summary: Glycans are diverse macromolecules that play critical roles in cell functions and host-microbe interactions. The gastrointestinal pathogen Campylobacter jejuni has extensive glycosylation capabilities and displays a variety of sugar-coated structures on its surface. It is associated with gastrointestinal disease, extraintestinal infections, and postinfectious autoimmune neuropathies, providing insights into molecular mimicry and autoimmune diseases.
ACS INFECTIOUS DISEASES
(2022)
Review
Gastroenterology & Hepatology
Yara El Dessouky, Salma W. Elsayed, Nehal Adel Abdelsalam, Nehal A. Saif, Avelino Alvarez-Ordonez, Mohamed Elhadidy
Summary: Campylobacteriosis is a global public health threat. High-throughput sequencing technologies can improve subtyping and resistance gene detection. The review aims to provide a comprehensive understanding of the epidemiology, clinical presentation, antibiotic resistance, and transmission dynamics of Campylobacter, with a focus on Campylobacter jejuni.
Article
Immunology
Daise Aparecida Rossi, Carolyne Ferreira Dumont, Ana Carolina de Souza Santos, Maria Eduarda de Lourdes Vaz, Renata Resende Prado, Guilherme Paz Monteiro, Camilla Beatriz da Silva Melo, Vassiliki Jaconi Stamoulis, Jandra Pacheco dos Santos, Roberta Torres de Melo
Summary: The study compared the effects of different classes of antimicrobials on planktonic and biofilm forms of Campylobacter jejuni, finding variations in susceptibility and resistance patterns among strains. Overall, all tested drugs showed antimicrobial action in planktonic form, with differences observed in biofilm production and effectiveness of tetracycline as an antibiofilm agent.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaofang Wu, Lei Ji, Yuehua Shen, Liping Chen, Deshun Xu, Fenfen Dong
Summary: Thirteen pathogenic Campylobacter strains were isolated from diarrhea cases and raw poultry meat products in Huzhou, including 11 Campylobacter jejuni and 2 Campylobacter coli strains. These strains contain multiple virulence-related genes and show high resistance to nalidixic acid, ciprofloxacin, and tetracycline. Genomic sequencing revealed the presence of tet(O) and blaOXA resistance genes in all C. jejuni strains and multiple drug resistance genes in 2 C. coli strains.
Article
Medicine, General & Internal
Audrey Jia Yin Ang, Michael McCann, Paul Stobie
Summary: Myocarditis is a type of inflammatory cardiomyopathy that can result from various infectious and non-infectious causes. It is a significant contributor to dilated cardiomyopathy globally and can range from a mild self-limiting illness to a severe cardiogenic shock requiring mechanical circulatory support and cardiac transplantation. This case report presents a man in his 50s with acute myocarditis secondary to Campylobacter jejuni infection, who developed acute coronary syndrome following a recent gastrointestinal illness.
Article
Biochemistry & Molecular Biology
Stefan Bereswill, Soraya Mousavi, Dennis Weschka, Agnes Buczkowski, Sebastian Schmidt, Markus M. Heimesaat
Summary: The increasing prevalence of food-borne Campylobacter jejuni infections is a serious health issue. Antibiotic therapy is not recommended, so novel treatment options are needed. This study focused on the use of an iron-chelating compound, desferoxamine (DESF), to alleviate the disease in a mouse model of acute campylobacteriosis. The results showed that oral application of DESF improved the clinical outcome of infected mice by reducing colonic cell damage, decreasing neutrophil accumulation, and inhibiting cytokine secretion.
Article
Microbiology
Soraya Mousavi, Dennis Weschka, Stefan Bereswill, Markus M. Heimesaat
Summary: This preclinical murine intervention study provides initial evidence for the promising treatment option of oral urolithin-A application in acute C. jejuni infection, paving the way for future clinical studies in human campylobacteriosis.
Article
Environmental Sciences
Shuxin Zhang, Jiahua Shi, Xuan Li, Lachlan Coin, Jake W. O'Brien, Muttucumaru Sivakumar, Faisal Hai, Guangming Jiang
Summary: This study developed a triplex qPCR assay for the detection and quantification of Campylobacter species in wastewater samples, specifically targeting C. jejuni and C. coli. The assay demonstrated high sensitivity and reliability, and can be used for long-term monitoring of Campylobacter prevalence in communities and surrounding environments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Immunology
Se-Hun Kim, Ramachandran Chelliah, Sudha Rani Ramakrishnan, Ayyappasamy Sudalaiyadum Perumal, Woo-Suk Bang, Momna Rubab, Eric Banan-Mwine Daliri, Kaliyan Barathikannan, Fazle Elahi, Eunji Park, Hyeon Yeong Jo, Su-Bin Hwang, Deog Hwan Oh
Summary: Campylobacter spp. are the leading cause of bacterial colon infections in humans globally, and their stress-adaptation mechanisms differ from other enteropathogenic bacteria, allowing them to survive in diverse environments and enhance their resistance mechanisms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Immunology
Fang Liu, Seul A. A. Lee, Jessica Xue, Stephen M. Riordan, Li Zhang
Summary: Campylobacteriosis is a global health concern that requires increased research and improved strategies for prevention. This review provides comprehensive and updated information on the global epidemiology of campylobacteriosis, including reported incidence and outbreaks. The COVID-19 pandemic has impacted the reported incidence of campylobacteriosis, with a decrease observed in most countries where data were available.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Graciela Volz Lopes, Tassiana Ramires, Natalie Rauber Kleinubing, Leticia Klein Scheik, Angela Maria Fiorentini, Wladimir Padilha da Silva
Summary: Campylobacter jejuni is a common cause of gastrointestinal foodborne disease worldwide, mainly transmitted through the food chain. Once in the human intestine, the pathogen may express multiple virulence factors and trigger inflammatory responses, leading to the development of various intestinal diseases.
MICROBIAL PATHOGENESIS
(2021)
Review
Food Science & Technology
Erika Austhof, Kylie Boyd, Kenzie Schaefer, Caitlyn McFadden, Ama Owusu-Dommey, Sandra Hoffman, Lorenzo Villa-Zapata, Deborah Jean McClelland, Kristen Pogreba-Brown
Summary: Previous economic estimates of Toxoplasma gondii infection and its chronic sequelae lack sufficient data to establish the true burden of disease. This scoping review aims to fill this gap by updating existing literature regarding postinfectious sequelae following T. gondii infection. The review covers a wide range of outcomes and economic estimates, providing important information for future research and policymakers.
FOODBORNE PATHOGENS AND DISEASE
(2021)