期刊
JOURNAL OF NEUROSCIENCE
卷 35, 期 32, 页码 11308-11314出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1553-15.2015
关键词
adolescence; fMRI; prefrontal cortex; risk taking
资金
- National Institute of Child Health and Human Development [R01HD057164-S, R01HD057164]
- National Science Foundation [SES 1023293]
Adolescence is a critical developmental phase during which risk-taking behaviors increase across a variety of species, raising the importance of understanding how brain changes contribute to such behaviors. While the prefrontal cortex is thought to influence adolescent risk taking, the specific ways in which it functions are unclear. Using longitudinal functional magnetic resonance imaging in human adolescents, we found that ventrolateral prefrontal cortex (VLPFC) activation decreased during an experimental risk-taking task over time, with greater declines in VLPFC associated with greater declines in self-reported risky behavior. Furthermore, greater decreases in functional coupling between the medial prefrontal cortex (MPFC) and ventral striatum over time were associated with decreases in self-reported risky behavior. Thus, disparate roles of the VLPFC and MPFC modulate longitudinal declines in adolescent risk taking.
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