期刊
CURRENT OPINION IN GASTROENTEROLOGY
卷 24, 期 2, 页码 108-114出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOG.0b013e3282f50fdf
关键词
caspase recruitment domain; innate immunity; intestinal host defense; microbial sensor
资金
- NCRR NIH HHS [RR17030, K26 RR017030] Funding Source: Medline
- NIAID NIH HHS [AI56075, R01 AI056075] Funding Source: Medline
- NIDDK NIH HHS [DK35108, R01 DK070867, R24 DK080506, DK80506, P01 DK035108, DK70867] Funding Source: Medline
Purpose of review The present review discusses the physiological functions of selected caspase recruitment domain (CARD)-containing sensor and adaptor proteins and their role in the pathogenesis of intestinal diseases. Recent findings Myeloid and lymphoid cells as well as intestinal epithelial cells express several intracellular CARD-containing proteins. CARD-containing sensors, particularly NOD1 (CARD4), NOD2 (CARD 15) and IPAF (CARD12), have an important role in the detection of conserved microbial structures of invading microbial pathogens. Upon ligand recognition and activation, the sensors interact through CARD domains with downstream CARD-containing adaptors including CARD9, RIP2 (CARD3) and ASC (CARD5). Recent data suggest that multiple signaling pathways from Toll-like receptors and non-Toll-receptor pathways converge on these adaptor proteins and that their functions are crucial for the initiation of innate immune responses to invading microbial pathogens. Summary CARD-containing adaptors and sensors represent an important family of molecules involved in innate host defense against gastrointestinal pathogens and in the regulation of inflammatory responses, suggesting that further insights into their physiological functions may yield new-pharmacological strategies for treating intestinal inflammatory conditions. Summary CARD-containing adaptors and sensors represent an important family of molecules involved in innate host defense against gastrointestinal pathogens and in the regulation of inflammatory responses, suggesting that further insights into their physiological functions may yield new-pharmacological strategies for treating intestinal inflammatory conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据