Review
Immunology
Chao Cao, Lin Zhang, Jie Shen
Summary: Phosgene gas is a highly toxic chemical intermediate with various industrial applications. Accidental exposure to phosgene can lead to chemical-induced lung injury, which is characterized by initial mild symptoms such as coughing and chest tightness, but can progress to severe respiratory distress and even death. Effective treatments for phosgene inhalation poisoning are currently lacking, highlighting the need to understand the pathophysiology and pathogenesis of this condition in order to develop appropriate therapeutics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiaoting Yang, Jing Wang, Wei Liu
Summary: In this study, molecular markers associated with type II alveolar epithelial cell injury in acute lung injury (ALI) were identified using bioinformatics methods. The results provide new insights for the diagnosis and treatment of ALI/ARDS.
SCIENTIFIC REPORTS
(2023)
Article
Plant Sciences
JunMei Wang, Chunxiu Ren, WenHui Bi, Wuliji Batu
Summary: Glycyrrhiza glabra L. is a widely used traditional Chinese medicine with various therapeutic effects. This study found that its active ingredient, glycyrrhizin, has anti-inflammatory effects and can alleviate acute lung injury (ALI) by interfering with the NF-κB/NLRP3 signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eleonore Froehlich
Summary: This review discusses pulmonary changes and treatment options for ARDS induced by viruses, focusing on the potential role of pulmonary lymphatics in the pathology. Although hyaluronan may play a role in ARDS, promising pharmacological treatments are unlikely due to the limited role of drugs in lymphedema therapy.
Review
Health Care Sciences & Services
Jan Benes, Jiri Kasperek, Olga Smekalova, Vaclav Tegl, Jakub Kletecka, Jan Zatloukal
Summary: Fluids are crucial in treating critically ill patients, and personalizing fluid therapy based on individual needs has been a focus in recent years. In patients with lung involvement, such as acute respiratory distress syndrome, finding the right amount of fluids after lung surgery is particularly important due to the vulnerability of lung tissue to fluid accumulation. In this narrative review, we explore the current perspectives on fluid therapy and the potential for tailoring treatment to individual patients using fluid responsiveness parameters and other therapeutic modalities.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Multidisciplinary Sciences
Yin Chen, Dong Wei, Jin Zhao, Xiangnan Xu, Jingyu Chen
Summary: Formononetin pretreatment significantly attenuates hyperoxia-induced ALI by increasing HO-1 expression and suppressing inflammation, dependent on the Nrf2/HO-1 signaling pathway.
Review
Biochemistry & Molecular Biology
Qianying Lu, Sifan Yu, Xiangyan Meng, Mingyu Shi, Siyu Huang, Junfeng Li, Jianfeng Zhang, Yangfan Liang, Mengjun Ji, Yanmei Zhao, Haojun Fan
Summary: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an inflammatory response that destroys lung parenchymal cells and reduces lung function. MicroRNAs play a crucial role in regulating inflammatory and immune responses in ALI/ARDS and may serve as diagnostic indicators and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pathology
Valeria Fridman D'Alessandro, Corina N. D'Alessandro-Gabazza, Taro Yasuma, Masaaki Toda, Atsuro Takeshita, Atsushi Tomaru, Suphachai Tharavecharak, Isaiah O. Lasisi, Rebecca Y. Hess, Kota Nishihama, Hajime Fujimoto, Tetsu Kobayashi, Isaac Cann, Esteban C. Gabazza
Summary: Acute lung injury (ALI) is characterized by lung inflammation that leads to respiratory distress syndrome and respiratory failure. The lung microbiota plays a role in ALI and a peptide called corisin derived from the lung microbiota is involved in ALI and pulmonary fibrosis exacerbation. Using a monoclonal anticorisin antibody to inhibit corisin can prevent ALI in mice. It is unknown whether inhibiting corisin with the antibody can ameliorate established ALI.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yohan Han, Yin Zhu, Sultan Almuntashiri, Xiaoyun Wang, Payaningal R. Somanath, Caroline A. Owen, Duo Zhang
Summary: The study reveals that CC16 released via small extracellular vesicles (sEVs) has anti-inflammatory activities and protects against ALI. sEV-encapsulated CC16 can activate DNA damage repair pathways and suppress NF-KB signaling by binding to HSP60. Therefore, sEV-CC16 could serve as a potential therapeutic agent for ALI by inhibiting inflammation and DNA damage responses.
Review
Medicine, General & Internal
Po-Lan Su, Zhanqi Zhao, Yen-Fen Ko, Chang-Wen Chen, Kuo-Sheng Cheng
Summary: Acute respiratory distress syndrome (ARDS) is characterized by rapid-deteriorating lung injury. Vigorous spontaneous breathing may aggravate lung injury. Increased lung stress and pendelluft are important mechanisms of patient self-inflicted lung injury.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Pei-Yao Liu, Chih-Yuan Chen, Yu-Lung Lin, Chien-Ming Lin, Wen-Chiuan Tsai, Yu-Ling Tsai, Gu-Jiun Lin, Yu-Guang Chen, Shih-Yun Wang, Rui-Nong Sun, Yu-Chuan Huang, Hung Chang, Ying-Chuan Chen
Summary: Acute lung injury (ALI) is a severe condition characterized by pulmonary inflammation, barrier disruption, and oedema. This study identifies RNF128 as a negative regulator of ALI by inhibiting neutrophil activation, reducing pro-inflammatory cytokines, and targeting TLR4 for degradation. Overexpression of RNF128 alleviates lung damage and reduces inflammatory cell infiltration, suggesting its potential as a therapeutic candidate for ALI.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Jing Liu, David A. Dean
Summary: Electroporation-mediated gene transfer of MRCK alpha attenuates LPS-induced acute lung injury in mice by reducing pulmonary edema, restoring tight junction protein expression, and improving overall outcomes. This approach may positively affect junctional complexes in alveolar and capillary endothelial cells, supporting a model where improvement of alveolar-capillary barrier function is more beneficial in treating ALI/ARDS than improving alveolar fluid clearance.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
David J. Hall, Jefree J. Schulte, Erik E. Lewis, Swaroop R. Bommareddi, Charles T. Rohrer, Samir Sultan, James D. Maloney, Malcolm M. DeCamp, Daniel P. McCarthy
Summary: This article reports a case of lung transplantation for post-COVID-19 pulmonary fibrosis. The patient recovered rapidly after the surgery and has done well in follow-up.
ANNALS OF THORACIC SURGERY
(2022)
Review
Nanoscience & Nanotechnology
Shuai Bian, Hongfei Cai, Youbin Cui, Wanguo Liu, Chunsheng Xiao
Summary: ALI and ARDS can cause life-threatening respiratory failure with a high mortality rate. Despite some clinical interventions, there is still no completely effective treatment for ALI. Recent advances in nanotechnology may provide new possibilities for the pharmacotherapy of ALI.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Medicine, Research & Experimental
Chaojin Chen, Yufeng He, Yawei Feng, Weilong Hong, Gangjian Luo, Zhiqiang Ye
Summary: Acute lung inflammatory diseases have a significant impact on patients' recovery and outcomes globally, with long noncoding RNAs (lncRNAs) playing a crucial role in acute inflammatory response. LncRNAs are involved in various cellular processes to limit potential deleterious effects.
Article
Sport Sciences
Behnam Bagherzadeh-Rahmani, Negin Kordi, Amir Hossein Haghighi, Cain C. T. Clark, Luca Brazzi, Emanuele Marzetti, Paulo Gentil
Summary: This study investigated the effects of Pilates and Aqua-Pilates training on pulmonary function and quality of life in patients with a history of COVID-19. The results showed that both types of training significantly improved pulmonary function and quality of life after 8 weeks, with Aqua-Pilates training showing greater improvements.
SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH
(2023)
Article
Physiology
David C. Berger, Lena Zwicker, Kay Nettelbeck, Daniela Casoni, Paul Phillipp Heinisch, Hansjorg Jenni, Matthias Haenggi, Luciano Gattinoni, Kaspar F. Bachmann
Summary: Assessment of native cardiac output during extracorporeal circulation is challenging. This study evaluated a modified Fick principle for accurately measuring cardiac output under different conditions. The findings provide important insights for understanding veno-arterial extracorporeal membrane oxygenation (V-A ECMO).
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Anesthesiology
Simone Gattarello, Silvia Coppola, Elena Chiodaroli, Tommaso Pozzi, Luigi Camporota, Leif Saager, Davide Chiumello, Luciano Gattinoni
Summary: This study assessed lung mechanics in nonintubated patients with COVID-19 pneumonia and found that patients in the treatment escalation group had higher respiratory rate, tidal volume, and mechanical power ratio compared to the no-treatment escalation group. Mechanical power, its ratio, and pressure-rate index showed the highest association with the clinical outcome.
Editorial Material
Anesthesiology
Simone Gattarello, Luigi Camporota, Luciano Gattinoni
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2023)
Letter
Critical Care Medicine
Serena Brusatori, Carmelo Zinnato, Tommaso Pozzi, Luigi Camporota, John J. Marini, Luciano Gattinoni
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Anesthesiology
Eleonora Balzani, Luca Neitzert, Giulio Luca Rosboch, Edoardo Ceraolo, Luca Brazzi
Letter
Anesthesiology
Luca Neitzert, Eleonora Balzani, Martina Petitti, Giulio L. Rosboch, Edoardo Ceraolo, Luca Brazzi
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Anesthesiology
Jochen Hinkelbein, Janusz Andres, Bernd W. Boettiger, Luca Brazzi, Edoardo De Robertis, Sharon Einav, Carl Gwinnutt, Bahar Kuvaki, Pawel Krawczyk, Matthew D. Mcevoy, Pieter Mertens, Vivek K. Moitra, Jose Navarro-Martinez, Mark E. Nunnally, Michael O'Connor, Marcus Rall, Kurt Ruetzler, Jan Schmitz, Karl Thies, Jonathan Tilsed, Mauro Zago, Arash Afshari
Summary: This guideline provides information and recommendations for the treatment of cardiac arrest in the operating room environment, including controversial topics such as open chest cardiac massage, resuscitative endovascular balloon occlusion, resuscitative thoracotomy, pericardiocentesis, needle decompression, and thoracostomy.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2023)
Editorial Material
Critical Care Medicine
Luciano Gattinoni, Francesca Collino, Luigi Camporota
INTENSIVE CARE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Silvia Corcione, Ilaria De Benedetto, Nour Shbaklo, Giulia Torsello, Tommaso Lupia, Gabriele Bianco, Rossana Cavallo, Luca Brazzi, Giorgia Montrucchio, Francesco Giuseppe De Rosa
Summary: The continuous spread of carbapenem-resistant Klebsiella pneumoniae (CP-Kp) strains poses a significant challenge to healthcare systems. Ceftazidime/avibactam (C/A) has been a first-line treatment, but C/A-resistant strains are increasing, especially among pneumonia patients or those with prior suboptimal blood exposure to C/A. A retrospective study was conducted on patients admitted to an ICU for COVID-19, with the primary purpose of studying C/A-resistant strains and describing the characteristics of the population. The study found a single clone of C/A-resistant KPC-Kp isolates with a D179Y mutation in the bla(KPC-2) gene.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Rosanna D'Albo, Federica Romitti, Luigi Camporota, Onnen Moerer, Mattia Busana, Luciano Gattinoni
Summary: The conditions of temperature, pressure, and saturation in which respiratory gas volumes are expressed are often ignored in clinical practice. This study investigates the effects of gas volume corrections on key respiratory and metabolic variables, and the possible clinical consequences. The findings suggest that gas volume corrections are mostly relevant when assessing CO2 clearance, and knowing when the appropriate corrections are needed allows for a better understanding of patients' clinical conditions and tailored treatment.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Review
Anesthesiology
Franco Cavaliere, Massimo Allegri, Alparslan Apan, Luca Brazzi, Massimiliano Carassiti, Edmond Cohen, Pierangelo DI Marco, Olivier Langeron, Marco Rossi, Peter Spieth, David Turnbull, Frank Weber
MINERVA ANESTESIOLOGICA
(2023)
Article
Medicine, General & Internal
Giorgia Montrucchio, Gabriele Sales, Eleonora Balzani, Davide Lombardo, Alice Giaccone, Giulia Cantu, Giulia D'Antonio, Francesca Rumbolo, Silvia Corcione, Umberto Simonetti, Chiara Bonetto, Marinella Zanierato, Vito Fanelli, Claudia Filippini, Giulio Mengozzi, Luca Brazzi
Summary: This study evaluates the effectiveness of MR-proADM in predicting mortality in critically ill patients with COVID-19 and compares it with routine inflammatory biomarkers, lymphocyte subpopulations, and immunoglobulin. The results show that MR-proADM is the best biomarker for predicting mortality in severe COVID-19 patients.
FRONTIERS IN MEDICINE
(2023)
Article
Emergency Medicine
Jochen Hinkelbein, Janusz Andres, Bernd W. Boettiger, Luca Brazzi, Edoardo De Robertis, Sharon Einav, Carl Gwinnutt, Bahar Kuvaki, Pawel Krawczyk, Matthew D. McEvoy, Pieter Mertens, Vivek K. Moitra, Jose Navarro-Martinez, Mark E. Nunnally, Michael O'Connor, Marcus Rall, Kurt Ruetzler, Jan Schmitz, Karl Thies, Jonathan Tilsed, Mauro Zago, Arash Afshari
Summary: This article discusses the recognition, treatment, and prevention of cardiac arrest in the operating room, and includes recommendations for open chest cardiac massage, resuscitative endovascular balloon occlusion, resuscitative thoracotomy, pericardiocentesis, needle decompression, and thoracostomy. Successful prevention and management of cardiac arrest during anaesthesia and surgery requires anticipation, early recognition, clear treatment plans, expert staff, and well-equipped facilities, as well as a culture of safety and continuous education and training.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Editorial Material
Critical Care Medicine
Luciano Gattinoni, Giuseppe Citerio, Arthur S. Slutsky
INTENSIVE CARE MEDICINE
(2023)