Review
Cell Biology
Marek Janotka, Petr Ostadal
Summary: The review summarizes the application of biochemical markers including SvO2, lactate, PCO2 gap, and PCO2 gap/Ca-vO2 for hemodynamic assessment of tissue perfusion. Thorough monitoring of tissue perfusion and oxygen supply is essential in critical conditions, leading to improved clinical outcomes.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Medicine, General & Internal
Paolo De Santis, Chiara De Fazio, Federico Franchi, Ottavia Bond, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone, Sabino Scolletta
Summary: This study aimed to assess the coherence between systemic hemodynamic and microcirculatory response to fluid challenge in critically ill patients. The results suggest inconsistency in fluid responsiveness between systemic and microvascular hemodynamics, indicating the need for larger prospective studies to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anesthesiology
Keitiane Kaefer, Charalampos Pierrakos, Thomas Nguyen, Dimitrios Velissaris, Rachid Attou, Jacques Devriendt, Sabino Scolletta, Fabio Silvio Taccone
Summary: This study investigated the association between the ratio of PvaCO2/CavO2 and decreases in blood-lactate levels in critically ill patients with hyperlactatemia. The results showed a positive correlation between changes in blood lactate and baseline PvaCO2/CavO2.
BMC ANESTHESIOLOGY
(2023)
Review
Critical Care Medicine
Jianneng Pan, Yuxiang Sun, Zhaojun Xu, Pingping Dong, Xiaoyang Zhou
Summary: This meta-analysis found that the variation in central venous oxygen saturation (?ScvO(2)) can reliably indicate fluid responsiveness in mechanically ventilated patients receiving volume expansion. The study concluded that ?ScvO(2) performs well in defining fluid responsiveness in this patient population.
Article
Critical Care Medicine
Wasineenart Mongkolpun, Peter Bakos, Jean-Louis Vincent, Jacques Creteur
Summary: This study included 42 patients with shock, and found that baseline skin blood flow and its early reduction after initiation of fluid removal using CVVH can predict worsened tissue perfusion, reflected by an increase in blood lactate levels.
ANNALS OF INTENSIVE CARE
(2021)
Article
Health Care Sciences & Services
Aslinur Sircan-Kucuksayan, Oktay Eray, Murat Buyukaksu, Birce Gumus, Oguz Dursun, Murat Canpolat
Summary: This study evaluated the potential of sublingual venous oxygen saturation in estimating central venous oxygen saturation. The results showed that sublingual venous oxygen saturation was similar to central venous oxygen saturation of healthy individuals, indicating its potential to non-invasively and in real-time estimate central venous oxygen saturation in intensive care units.
TECHNOLOGY AND HEALTH CARE
(2022)
Article
Critical Care Medicine
Wasineenart Mongkolpun, Mickael Gardette, Diego Orbegozo, Jean-Louis Vincent, Jacques Creteur
Summary: This study aimed to investigate whether an increase in skin blood flow after fluid challenge was associated with an increase in oxygen consumption in patients with circulatory shock. Results showed that patients with increased oxygen consumption after fluid challenge had lower baseline skin blood flow and a greater increase in skin blood flow, suggesting an improvement in cellular metabolism.
JOURNAL OF CRITICAL CARE
(2022)
Review
Biotechnology & Applied Microbiology
Arinola O. Lampejo, Nien-Wen Hu, Daniela Lucas, Banks M. Lomel, Christian M. Nguyen, Carmen C. Dominguez, Bing Ren, Yong Huang, Walter L. Murfee
Summary: The development of biomimetic models bridges the gap between in vitro and in vivo assays, providing tools for studying microvascular dynamics. A key challenge is to recreate the functional complexity of a real network environment. Engineering design requirements and top-down tissue culture methods help achieve the matching of physiological function.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
J. Walladbegi, J. E. Raber-Durlacher, M. Jontell, D. M. J. Milstein
Summary: Oral cryotherapy reduces tissue microcirculation and prevents oral mucositis. This study examined the underlying mechanism by measuring oral microcirculation and tissue oxygen saturation. The results showed that both microcirculation parameters and tissue oxygen saturation were altered after oral cooling.
Article
Anesthesiology
Yan Chen, Jin-min Peng, Xiao-yun Hu, Shan Li, Xi-xi Wan, Rui-ting Liu, Chun-yao Wang, Wei Jiang, Run Dong, Long-xiang Su, Huai-wu He, Yun Long, Li Weng, Bin Du
Summary: This study found that tissue oxygen saturation (StO(2)) decrease may occur earlier than lactate alteration, and body surface area (BSA)-weighted StO(2) is a strong predictor of 6-hour lactate clearance in patients with shock.
BMC ANESTHESIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xuebing Yang, Yaqing Zhou, Aiming Liu, Zunguo Pu
Summary: The changes in microcirculation perfusion parameters and blood lactic acid level of patients with septic shock in the ICU are closely related to the prognosis, and have great value in evaluating the prognosis of these patients.
CONTRAST MEDIA & MOLECULAR IMAGING
(2022)
Article
Anesthesiology
Norddine Zeroual, Cinderella Blin, Marine Saour, Helene David, Safa Aouinti, Marie-Christine Picot, Pascal H. Colson, Philippe Gaudard
Summary: Recent guidelines on transfusion in cardiac surgery suggest that hemoglobin might not be the only criterion to trigger transfusion. Instead, central venous oxygen saturation (Svo(2)) could help in the decision process of transfusion. A randomized study showed that a restrictive transfusion strategy adjusted with central Svo(2) could significantly reduce the incidence of transfusion after cardiac surgery.
Article
Critical Care Medicine
Amjad N. Kanj, Lucrezia Rovati, Claudia Castillo Zambrano, Alberto Marquez, Kellie Robbins, Gustavo Cortes Puentes, Alice Gallo De Moraes, Ognjen Gajic
Summary: This study aimed to assess the occurrence of low ScvO(2) in patients with severe hypoxemia and its association with clinical management and patient outcomes. The results showed that 56% of mechanically ventilated patients with severe hypoxemia had ScvO(2) <70%. Patients with low ScvO(2) had worse systemic oxygenation and hemodynamic parameters, and were more likely to undergo blood transfusions and receive medications.
Review
Critical Care Medicine
Jan Bakker
Summary: Resuscitation goals in septic shock involve fixed volume of fluids and vasopressors to correct hypotension and improve tissue perfusion, with abnormal peripheral perfusion associated with increased mortality. Ongoing resuscitation in septic shock patients with normal peripheral perfusion does not improve outcome, but may lead to increased mortality. Using parameters of peripheral perfusion to guide resuscitation efforts may be beneficial for patients with septic shock.
CURRENT OPINION IN CRITICAL CARE
(2021)
Article
Anesthesiology
Pierre Huette, Christophe Beyls, Jihad Mallat, Lucie Martineau, Patricia Besserve, Guillaume Haye, Mathieu Guilbart, Herve Dupont, Pierre-Gregoire Guinot, Momar Diouf, Yazine Mahjoub, Osama Abou-Arab
Summary: The venous-to-arterial carbon dioxide partial pressure difference (CO2 gap) is associated with postoperative adverse outcomes after cardiac surgery with cardiopulmonary bypass (CPB), but it shows poor diagnostic performance.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2021)
Article
Materials Science, Paper & Wood
Ricardo I. Castro, Ana Gonzalez-Feliu, Felipe Valenzuela-Riffo, Carolina Parra-Palma, Luis Morales-Quintana
Summary: Evidence suggests that ABA promotes fruit ripening in strawberries by degrading cell wall polymers, especially hemicellulose, as shown through thermogravimetric analysis. Samples treated with an ABA biosynthesis inhibitor maintained thermal stability, indicating a link between thermal stability, transcriptional analysis, and enzymatic activity. These findings provide insight into changes in cell wall polymers during fruit ripening mediated by the ABA hormone.
Article
Critical Care Medicine
L. Felipe Damiani, Doreen Engelberts, Luca Bastia, Kohei Osada, Bhushan H. Katira, Gail Otulakowski, Ewan C. Goligher, W. Darlene Reid, Sebastian Dubo, Alejandro Bruhn, Martin Post, Brian P. Kavanagh, Laurent J. Brochard
Summary: This study found that reverse triggering dyssynchrony (RT) may have an impact on the structure and function of the diaphragm. RT with high breathing effort is associated with impaired diaphragm function, while RT with low breathing effort can preserve diaphragm force.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Editorial Material
Critical Care Medicine
L. Felipe Damiani, Alejandro Brettln
Article
Public, Environmental & Occupational Health
Luigi Pisani, Anna Geke Algera, Ary Serpa Neto, Luciano Azevedo, Tai Pham, Frederique Paulus, Marcelo Gama de Abreu, Paolo Pelosi, Arjen M. Dondorp, Giacomo Bellani, John G. Laffey, Marcus J. Schultz
Summary: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in middle income countries (MICs) than in high-income countries (HICs), with a strong association with country-level economic status.
LANCET GLOBAL HEALTH
(2022)
Article
Critical Care Medicine
Manoj Maddali, Matthew Churpek, Tai Pham, Emanuele Rezoagli, Hanjing Zhuo, Wendi Zhao, June He, Kevin L. Delucchi, Chunxue Wang, Nancy Wickersham, J. Brennan McNeil, Alejandra Jauregui, Serena Ke, Kathryn Vessel, Antonio Gomez, Carolyn M. Hendrickson, Kirsten N. Kangelaris, Aartik Sarma, Aleksandra Leligdowicz, Kathleen D. Liu, Michael A. Matthay, Lorraine B. Ware, John G. Laffey, Giacomo Bellani, Carolyn S. Calfee, Pratik Sinha
Summary: Clinical classifier models based on machine learning can accurately assign ARDS subphenotypes, providing valuable prognostic information for patients and potentially guiding personalized treatment strategies in clinical practice.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Multidisciplinary Sciences
Luis F. Reyes, Alirio Bastidas, Paula O. Narvaez, Daniela Parra-Tanoux, Yuli Fuentes, Cristian C. Serrano-Mayorga, Valentina Ortiz, Eder L. Caceres, Gustavo Ospina-Tascon, Ana M. Diaz, Manuel Jibaja, Magdalena Vera, Edwin Silva, Luis Antonio Gorordo-Delsol, Francesca Maraschin, Fabio Varon-Vega, Ricardo Buitrago, Marcela Poveda, Lina M. Saucedo, Elisa Estenssoro, Guillermo Ortiz, Nicolas Nin, Luis E. Calderon, Gina S. Montano, Aldair J. Chaar, Fernanda Garcia, Vanessa Ramirez, Fabricio Picoita, Cristian Pelaez, Luis Unigarro, Gilberto Friedman, Laura Cucunubo, Alejandro Bruhn, Glenn Hernandez, Ignacio Martin-Loeches
Summary: This study aims to investigate the clinical characteristics, in-hospital outcomes, and factors associated with ICU admission due to COVID-19 in Latin American countries. The results show a lower mortality rate for COVID-19 patients in Latin America compared to previous reports, but a higher mortality rate for ICU patients. Additionally, patients discharged from the ICU had worse self-care ability.
Article
Critical Care Medicine
L. Felipe Damiani, Vanessa Oviedo, Leyla Alegria, Dagoberto Soto, Roque Basoalto, M. Consuelo Bachmann, Yorschua Jalil, Cesar Santis, Magdalena Vera, Jaime Retamal, Alejandro Bruhn, Guillermo Bugedo
Article
Multidisciplinary Sciences
Maria Consuelo Bachmann, Pablo Cruces, Franco Diaz, Vanessa Oviedo, Mariela Goich, Jose Fuenzalida, Luis Felipe Damiani, Roque Basoalto, Yorschua Jalil, David Carpio, Niki Hamidi Vadeghani, Rodrigo Cornejo, Maximiliano Rovegno, Guillermo Bugedo, Alejandro Bruhn, Jaime Retamal
Summary: Spontaneous breathing during the early stage of acute respiratory failure can lead to lung injury, but this can be prevented by early application of controlled mechanical ventilation. However, late application of controlled mechanical ventilation is ineffective in preventing lung injury in a lung collapse model.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Rodrigo A. Cornejo, Daniel H. Arellano, Pablo Ruiz-Rudolph, Dannette Guinez, Caio C. A. Morais, Abraham I. J. Gajardo, Marioli T. Lazo, Roberto E. Brito, Maria A. Cerda, Sedric J. Gonzalez, Veronica A. Rojas, Gonzalo A. Diaz, Lorena D. M. Lopez, Juan N. Medel, Dagoberto Soto, Alejandro R. Bruhn, Marcelo B. P. Amato, Nivia R. Estuardo
Summary: The transition from controlled to partial support ventilation in ARDS patients is challenging due to the risk of patient-self-inflicted lung injury. This study found a potential association between the frequency of high magnitude pendelluft and inflammatory response. Further research is needed to confirm these findings.
SCIENTIFIC REPORTS
(2022)
Article
Critical Care Medicine
Rodrigo A. Cornejo, Jorge Montoya, Abraham I. J. Gajardo, Jeronimo Graf, Leyla Alegria, Romyna Baghetti, Anita Irarrazaval, Cesar Santis, Nicolas Pavez, Sofia Leighton, Vinko Tomicic, Daniel Morales, Carolina Ruiz, Pablo Navarrete, Patricio Vargas, Roberto Galvez, Victoria Espinosa, Marioli Lazo, Rodrigo A. Perez-Araos, Osvaldo Garay, Patrick Sepulveda, Edgardo Martinez, Alejandro Bruhn
Summary: This study analyzed the feasibility and safety of a nationwide implementation of a continuous prolonged prone positioning strategy for COVID-19 patients. The study found that the duration of prone sessions did not have an adverse effect on safety, and the strategy was feasible.
ANNALS OF INTENSIVE CARE
(2022)
Article
Health Care Sciences & Services
Jose Escalona, Dagoberto Soto, Vanessa Oviedo, Elizabeth Rivas, Nicolas Severino, Eduardo Kattan, Max Andresen, Sebastian Bravo, Roque Basoalto, Maria Consuelo Bachmann, Kwok-Yin Wong, Nicolas Pavez, Alejandro Bruhn, Guillermo Bugedo, Jaime Retamal
Summary: This study examined the correlation between beta-lactam antibiotic concentrations in exhaled breath condensate collected from heat and moisture exchange filters (HMEFs) and antibiotic concentrations in bronchoalveolar lavage (BAL). Antibiotics were detected in plasma, epithelial lining fluid (ELF), and HMEFs from all 12 mechanically ventilated patients studied. However, no significant correlations were found between the antibiotic concentrations in HMEFs and either plasma or ELF.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
F. Damiani, R. Basoalto, M. Bachmann, Y. Jalil, V. Acuna, G. Diaz, J. Mella, P. Garcia, E. Moya, G. Villarroel, J. A. Retamal Montes, G. Bugedo, A. Bruhn
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
R. Basoalto, L. Damiani, Y. Jalil, P. Garcia, D. Carpio, M. Bachmann, L. Alegria, V. Oviedo, G. Bugedo, J. Retamal, A. Bruhn
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
M. Vera, J. Angulo, R. Medina, M. Ferres, A. Bruhn, R. Castro, C. Pardo-Roa
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Mariano Esperatti, Marina Busico, Nora Angelica Fuentes, Adrian Gallardo, Javier Osatnik, Alejandra Vitali, Elizabeth Gisele Wasinger, Matias Olmos, Jorgelina Quintana, Santiago Nicolas Saavedra, Ana Ines Lagazio, Facundo Juan Andrada, Hiromi Kakisu, Nahuel Esteban Romano, Agustin Matarrese, Mariela Adriana Mogadouro, Giuliana Mast, Claudia Navarro Moreno, Greta Dennise Rebaza Niquin, Veronica Barbaresi, Alejandro Bruhn Cruz, Bruno Leonel Ferreyro, Antoni Torres
Summary: Awake prone positioning (AW-PP) reduces the need for intubation in patients with COVID-19-related acute respiratory failure (ARF) treated with high-flow nasal oxygen (HFNO). Longer exposure to AW-PP further reduces hospital mortality.