Review
Allergy
Catherine Hammond
Summary: This article discusses the different definitions of anaphylaxis and reviews the latest research on various subtypes of anaphylaxis and its implications for clinical practice.
CURRENT ALLERGY AND ASTHMA REPORTS
(2023)
Article
Health Care Sciences & Services
Nikolaos Pyrpyris, Maria Kritikou, Xenofon Aggelidis, Ioanna Manolaraki, Michael Makris, Nikolaos G. Papadopoulos, Paraskevi Xepapadaki
Summary: This study analyzes the characteristics of anaphylaxis in a pediatric cohort in Greece and finds a low rate of adrenaline autoinjector administration by lay people. However, drug prescription and counseling after the reaction could help improve correct acute anaphylaxis management in the future.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Clinical Neurology
Boulenouar Mesraoua, Francesco Brigo, Simona Lattanzi, Bassel Abou-Khalil, Hassan Al Hail, Ali A. Asadi-Pooya
Summary: There are over 51 million people with epilepsy worldwide, with more than 4.9 million new cases each year. Although drug therapy is the main treatment for epilepsy, approximately one-third of patients do not respond well to medication (drug-resistant epilepsy). This review aims to discuss the definition of drug-resistant epilepsy, explore its biological underpinnings and clinical biomarkers, and suggest practical management strategies to address this issue effectively.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Review
Immunology
Nicholas G. Kounis, Ioanna Koniari, Cesare de Gregorio, Dimitris Velissaris, Konstantinos Petalas, Aikaterini Brinia, Stelios F. Assimakopoulos, Christos Gogos, Sophia N. Kouni, George N. Kounis, GianFranco Calogiuri, Ming-Yow Hung
Summary: Vaccines are highly effective in public health, but can trigger allergic reactions, particularly severe ones that activate mast cells and lead to anaphylactic shock. Allergic reactions to vaccines are typically caused by excipients rather than the active vaccine itself.
Review
Obstetrics & Gynecology
Michal Fishel Bartal, Marshall D. Lindheimer, Baha M. Sibai
Summary: In pregnancy, the measurement of urine protein excretion is common, and recent guidelines suggest that proteinuria alone is sufficient for the diagnosis of preeclampsia. While a 24-hour urine collection is the reference standard, the urine protein-to-creatinine ratio is a reasonable test to rule out proteinuria.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Immunology
Marine Michelet, Bianca Balbino, Laurent Guilleminault, Laurent L. Reber
Summary: Food allergy poses a significant public health issue without an approved therapy, with IgE antibodies playing a crucial role in diagnosis and treatment. Recent advances in regulating IgE production and understanding its function in food allergy offer hope for better management and treatment options. Clinical studies on anti-IgE therapeutic monoclonal antibodies provide insights into blocking IgE effector functions and improving outcomes for individuals with food allergies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Daniel Bushyhead, Eamonn M. M. Quigley
Summary: The concept of small intestinal bacterial overgrowth (SIBO) explains the cause of maldigestion and malabsorption. With the development of diagnostic testing, the methods for diagnosing SIBO have evolved from small bowel culture to breath tests and culture-independent microbial analytics. The availability of breath tests has led to an expansion in the diagnosis of SIBO and the associated clinical symptoms. However, issues with the specificity of breath tests have raised doubts about the role of SIBO in certain clinical scenarios. The hope is to use modern molecular microbiology to study the human small intestinal microbiome in order to provide an objective basis for diagnosing SIBO.
Review
Allergy
Sophie Carra, Michael Schatz, Paul-Michel Mertes, Maria Jose Torres, Florence Fuchs, Gianenrico Senna, Mariana C. Castells, Pascal Demoly, Luciana Kase Tanno
Summary: Anaphylaxis during pregnancy is rare but poses risks to both mother and newborn. Identified causes include beta-lactam antibiotics, latex, and anesthetic agents. Most literature suggests similar management and treatment for pregnant and non-pregnant patients experiencing anaphylaxis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Review
Oncology
Meinolf Suttorp, Frederic Millot, Stephanie Sembill, Helene Deutsch, Markus Metzler
Summary: This article aims to provide a unified approach for the differential diagnosis, pathological features, and treatment methods of pediatric chronic myeloid leukemia. By detailing the biological characteristics and complications of patients, a clear understanding is crucial for accurate diagnosis and management of this rare disease.
Article
Immunology
Michael S. Gold, Ananda Amarasinghe, Matthew Greenhawt, John M. Kelso, Sonali Kochhar, Bernard Yu-Hor Thong, Karina A. Top, Paul J. Turner, Margitta Worm, Barbara Law
Summary: The Brighton Collaboration (BC) has revised its case definition for anaphylaxis, which has been widely used in evaluating reports of suspected anaphylaxis following COVID-19 vaccination. This revision aligns the BC definition with other international case definitions and emphasizes the reporting of observable clinical signs. The BC definition is based on expert consensus and a literature review process.
Article
Critical Care Medicine
Jeffrey L. Curtis
Summary: COPD, a major global health problem, lacks effective disease-modifying therapies for most patients due to the heterogeneity of phenotypes. Progress has been made in understanding specific pathological processes and developing personalized therapies. However, there is a need to expand diagnostic criteria for COPD to include more individuals with similar disease manifestations.
Review
Allergy
Debra de Silva, Chris Singh, Antonella Muraro, Margitta Worm, Cherry Alviani, Victoria Cardona, Audrey DunnGlvin, Lene Heise Garvey, Carmen Riggioni, Elizabeth Angier, Stefania Arasi, Abdelouahab Bellou, Kirsten Beyer, Diola Bijlhout, M. Beatrice Bilo, Knut Brockow, Montserrat Fernandez-Rivas, Susanne Halken, Britt Jensen, Ekaterina Khaleva, Louise J. Michaelis, Hanneke Oude Elberink, Lynne Regent, Angel Sanchez, Berber Vlieg-Boerstra, Graham Roberts
Summary: This systematic review found limited and uncertain evidence on the diagnosis, management, and prevention strategies of anaphylaxis. Adrenaline is commonly used for emergency management, but robust research on its effectiveness is lacking.
Review
Cardiac & Cardiovascular Systems
Konstantin A. Krychtiuk, Christiaan Vrints, Johann Wojta, Kurt Huber, Walter S. Speidl
Summary: Despite advances in cardiovascular medicine and the use of mechanical circulatory support systems, mortality rates for cardiogenic shock remain high. Currently used therapeutic measures have limited evidence supporting their effectiveness, highlighting the need for further action. This educational review focuses on defining cardiogenic shock, discussing current treatment strategies, and summarizing knowledge on the underlying mechanisms, particularly inflammation and microvascular disturbances, which may lead to improved diagnostic and therapeutic approaches.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2022)
Review
Cardiac & Cardiovascular Systems
Amer Harky, Bianca Botezatu, Sahil Kakar, Moliu Ren, Manasi Mahesh Shirke, Mark Pullan
Summary: Valvular heart disease is common among the elderly and early diagnosis and interventions are crucial. Treatment methods include surgery and interventional therapy. The management of valve diseases is continuously evolving.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Urology & Nephrology
Shani Shastri, Jiten Patel, Kamalanathan K. Sambandam, Eleanor D. Lederer
Summary: Kidney stone disease is a complex condition that requires comprehensive evaluation and multifaceted care. It is often a manifestation of underlying systemic medical conditions. Nephrologists and urologists should lead a team of healthcare professionals in the treatment of kidney stone disease.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Alexandre Mebazaa, M. Birhan Yilmaz, Phillip Levy, Piotr Ponikowski, W. Frank Peacock, Said Laribi, Arsen D. Ristic, Ekaterini Lambrinou, Josep Masip, Jillian P. Riley, Theresa McDonagh, Christian Mueller, Christopher deFilippi, Veli-Pekka Harjola, Holger Thiele, Massimo F. Piepoli, Marco Metra, Aldo Maggioni, John J. V. McMurray, Kenneth Dickstein, Kevin Damman, Petar M. Seferovic, Frank Ruschitzka, Adelino F. Leite-Moreira, Abdelouahab Bellou, Stefan D. Anker, Gerasimos Filippatos
EUROPEAN HEART JOURNAL
(2015)
Review
Cardiac & Cardiovascular Systems
Alexandre Mebazaa, M. Birhan Yilmaz, Phillip Levy, Piotr Ponikowski, W. Frank Peacock, Said Laribi, Arsen D. Ristic, Ekaterini Lambrinou, Josep Masip, Jillian P. Riley, Theresa McDonagh, Christian Mueller, Christopher deFilippi, Veli-Pekka Harjola, Holger Thiele, Massimo F. Piepoli, Marco Metra, Aldo Maggioni, John McMurray, Kenneth Dickstein, Kevin Damman, Petar M. Seferovic, Frank Ruschitzka, Adelino F. Leite-Moreira, Abdelouahab Bellou, Stefan D. Anker, Gerasimos Filippatos
EUROPEAN JOURNAL OF HEART FAILURE
(2015)
Article
Medicine, General & Internal
Hsuan-Yu Chen, Hung-Chen Chen, Meng-Chih Lin, Mei-Yun Liaw
Article
Critical Care Medicine
Abdelouahab Bellou, Suleiman Al-Hammadi, Elhadi H. Aburawi, Subramanian Dhanasekaran, Abderrahim Nemmar, Abderrahim Oulhaj, Mohamed Shafiuallah, Moufida Zerrouki, Javed Yasin, Leila Bellou, Seth L. Alper, Sirine Bellou, Elsadig Kazzam
CRITICAL CARE MEDICINE
(2016)
Editorial Material
Emergency Medicine
Abdelouahab Bellou, Simon P. Conroy, Colin A. Graham
EUROPEAN JOURNAL OF EMERGENCY MEDICINE
(2016)
Article
Geriatrics & Gerontology
S. Conroy, C. H. Nickel, A. B. Jonsdottir, M. Fernandez, J. Banerjee, S. Mooijaart, F. Sjostrand, E. Devriendt, O. Ganansia, F. J. Martin-Sanchez, A. Bellou
EUROPEAN GERIATRIC MEDICINE
(2016)
Article
Medicine, General & Internal
Paul Erne, Andrea Mueller, Gian Paolo Rossi, Burkhardt Seifert, Fabrice Stehlin, Maurice Redondo, Peter T. Bauer, Richard Kobza, Therese J. Resink, Dragana Radovanovic
Review
Biology
Maryam Alfalasi, Sarah Alzaabi, Linda Ostlundh, Rami H. Al-Rifai, Suhail Al-Salam, Paul Michel Mertes, Seth L. Alper, Elhadi H. Aburawi, Abdelouahab Bellou
Summary: This systematic review assessed the effect of inhibiting nitric oxide pathways on blood pressure and survival in animal models of anaphylactic shock (AS). The results showed that inhibition of nitric oxide pathways improved survival and/or blood pressure in some experimental conditions. However, there is insufficient evidence to support the use of this approach as a definitive treatment for AS in humans.
Article
Biology
Abdelouahab Bellou, Nacira Sennoun, Elhadi H. Aburawi, Richard L. Jayaraj, Seth L. Alper, Ibrahim Abdallah Alfaki, Javed Yasin, Subramanian Sekar, Mohamed Shafiuallah, Suhail Al-Salam, Abderrahim Nemmar, Elsadig Kazzam, Paul Michel Mertes, Suleiman Al-Hammadi
Summary: The mechanism of anaphylactic shock and potential treatments were investigated using experiments on ovalbumin rats. The potassium channel blocker 4-aminopyridine (4-AP) was found to be effective in restoring blood pressure and improving survival rates, especially when used in combination with other drugs.
Review
Medicine, General & Internal
Dominique Lauque, Anna Khalemsky, Zoubir Boudi, Linda Ostlundh, Chang Xu, Mohammed Alsabri, Churchill Onyeji, Jacqueline Cellini, Geroge Intas, Kapil Dev Soni, Detajin Junhasavasdikul, Jose Javier Trujillano Cabello, Niels K. Rathlev, Shan W. Liu, Carlos A. Camargo, Anna Slagman, Michael Christ, Adam J. Singer, Charles-Henri Houze-Cerfon, Elhadi H. Aburawi, Karim Tazarourte, Lisa Kurland, Phillip D. Levy, James H. Paxton, Dionyssios Tsilimingras, Vijaya Arun Kumar, David G. Schwartz, Eddy Lang, David W. Bates, Gabriele Savioli, Shamai A. Grossman, Abdelouahab Bellou
Summary: This systematic review and meta-analysis aimed to determine the association between emergency department length of stay (EDLOS) and in-hospital mortality (IHM). The analysis of multiple studies showed a significant association between EDLOS over 24 hours and IHM in ICU-admitted patients, as well as a correlation between low EDLOS and IHM in non-ICU admitted patients. This highlights the importance of minimizing prolonged stays in the emergency department and providing special attention to patients admitted after a short ED stay.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Xuanhui Chen, Jiaxin Li, Guangjian Liu, Xiujuan Chen, Shuai Huang, Huixian Li, Siyi Liu, Dantong Li, Huan Yang, Haiqing Zheng, Lianting Hu, Lingcong Kong, Huazhang Liu, Abdelouahab Bellou, Liming Lei, Huiying Liang
Summary: This retrospective study aimed to predict the outcomes of ventilated ICU patients on the first day of ventilation by deriving their clinical phenotypes. Cluster analysis was performed on the eICU and MIMIC-IV cohorts to identify and validate four clinical phenotypes. These phenotypes showed heterogeneity among ICU patients and were associated with different mortality and extubation success rates. They also responded differently to ventilation strategies in terms of treatment duration, but did not have a difference in mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Nicole Gri, Yaroslava Longhitano, Christian Zanza, Valentina Monticone, Damiano Fuschi, Andrea Piccioni, Abdelouahab Bellou, Ciro Esposito, Iride Francesca Ceresa, Gabriele Savioli
Summary: This article discusses the management of cancer-related emergencies in the emergency department and the role of emergency physicians in this regard. It highlights the need for a redefinition of the emergency department to consider the treatment and care of oncology patients, acute oncological symptoms, and palliative care.
Article
Medicine, General & Internal
Lijuan Wu, Xuanhui Chen, Anna Khalemsky, Deyang Li, Taoufik Zoubeidi, Dominique Lauque, Mohammed Alsabri, Zoubir Boudi, Vijaya Arun Kumar, James Paxton, Dionyssios Tsilimingras, Lisa Kurland, David Schwartz, Said Hachimi-Idrissi, Carlos A. Camargo Jr, Shan W. Liu, Gabriele Savioli, Geroge Intas, Kapil Dev Soni, Detajin Junhasavasdikul, Jose Javier Trujillano Cabello, Niels K. Rathlev, Karim Tazarourte, Anna Slagman, Michael Christ, Adam J. Singer, Eddy Lang, Giovanni Ricevuti, Xin Li, Huiying Liang, Shamai A. Grossman, Abdelouahab Bellou
Summary: This retrospective study aims to investigate the relationship between emergency department (ED) length of stay (EDLOS) and inhospital mortality (IHM) in elderly patients. The study found a significant correlation between EDLOS and IHM, with a higher risk of IHM in patients with shorter EDLOS and longer boarding time (BT). Specific areas and teams dedicated to older patients care could be proposed to policymakers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Angela Saviano, Christian Zanza, Yaroslava Longhitano, Veronica Ojetti, Francesco Franceschi, Abdelouahab Bellou, Antonio Voza, Iride Francesca Ceresa, Gabriele Savioli
Summary: Delirium is a commonly overlooked acute neurological disorder among older patients in the emergency department. While there are screening tools available for assessing delirium in other settings, their validation and application in the ED have not been established. This review aims to summarize the current evidence on screening tools for delirium in the context of the ED.
MEDICINA-LITHUANIA
(2023)
Article
Emergency Medicine
D. Lauque, S. Fernandez, N. Lecoules, S. Charpentier, O. Azema, J. Edlow, A. Bellou
ANNALES FRANCAISES DE MEDECINE D URGENCE
(2017)
