Review
Biochemistry & Molecular Biology
Qianying Lu, Sifan Yu, Xiangyan Meng, Mingyu Shi, Siyu Huang, Junfeng Li, Jianfeng Zhang, Yangfan Liang, Mengjun Ji, Yanmei Zhao, Haojun Fan
Summary: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an inflammatory response that destroys lung parenchymal cells and reduces lung function. MicroRNAs play a crucial role in regulating inflammatory and immune responses in ALI/ARDS and may serve as diagnostic indicators and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nanoscience & Nanotechnology
Shuai Bian, Hongfei Cai, Youbin Cui, Wanguo Liu, Chunsheng Xiao
Summary: ALI and ARDS can cause life-threatening respiratory failure with a high mortality rate. Despite some clinical interventions, there is still no completely effective treatment for ALI. Recent advances in nanotechnology may provide new possibilities for the pharmacotherapy of ALI.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Critical Care Medicine
Analia Fernandez, Vicent Modesto, Peter C. Rimensberger, Steven K. Korang, Narayan P. Iyer, Ira M. Cheifetz
Summary: This study aims to provide evidence and recommendations for invasive mechanical ventilation support of patients with pediatric acute respiratory distress syndrome (PARDS). Through the analysis of pediatric and adult acute respiratory distress syndrome literature, recommendations and guidelines for mechanical ventilation in pediatric patients were developed. However, further research is needed due to the limited pediatric data available for the management of PARDS patients requiring invasive mechanical ventilation.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Laetitia Pouzol, Anna Sassi, Nadege Baumlin, Melanie Tunis, Daniel S. Strasser, Francois Lehembre, Marianne M. Martinic
Summary: The loss of control in immune cell trafficking to inflamed lung tissue leads to ALI/ARDS. The paper investigates the pathological role of the CXCR3/CXCR4/CXCR7 axis in a murine model of ALI. The study suggests the clinical potential of the CXCR7 antagonist, ACT-1004-1239, in reducing inflammation and improving lung function in ALI/ARDS.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Chang Liu, Kun Xiao, Lixin Xie
Summary: This review discusses the pathogenesis of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and the biological characteristics and mechanisms of mesenchymal stromal cells (MSCs) in the treatment of ALI/ARDS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Zhuoran Xiao, Song Hu, Wenting Xu, Sheng Wang, Wei Mo, Huimin Deng, Juan Wei, Hao Yang, Wenyu Zhou, Quanfu Li, Huanping Zhou, Xin Lv
Summary: This bibliometric analysis reveals a rapid growth trend of NLRP3 inflammasome in ALI/ARDS. China is the largest contributor, while the USA offers the most landmark papers. The major disciplines of research front have shifted from Medicine, Medical, Clinical to Molecular, Biology, Immunology. In recent years, studies on the role of NLRP3 in COVID-19-associated ALI/ARDS and oxidative stress have become hotspots.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Physiology
Thijs A. Lilien, David M. P. Van Meenen, Marcus J. Schultz, Lieuwe D. J. Bos, Reinout A. Bem
Summary: The interest in oxygen toxicity has led to numerous studies, but there is still no consensus on the clinical impact of hyperoxia and hyperoxemia. This article explores the importance of hyperoxia-induced lung injury in current critical care practice, suggesting that it may be less important than other ventilator-related factors in patients with acute respiratory distress syndrome.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Critical Care Medicine
Haruka Hashimoto, Takeshi Yoshida, Andi Muhammad Fadlillah Firstiogusran, Hiroki Taenaka, Ryota Nukiwa, Yukiko Koyama, Akinori Uchiyama, Yuji Fujino
Summary: Patient-ventilator asynchrony during mechanical ventilation may lead to lung and diaphragm injury. Breath stacking has a more detrimental effect on oxygenation, lung compliance, and lung injury compared to assist control, while reverse triggering predominantly causes diaphragm injury. Therefore, careful monitoring and management of patient-ventilator asynchrony is crucial in minimizing lung and diaphragm injury in ARDS patients.
CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Anoopindar Bhalla, Florent Baudin, Muneyuki Takeuchi, Pablo Cruces
Summary: Monitoring is crucial for assessing changes in lung condition, identifying heart-lung interactions, and improving respiratory support and therapy in pediatric acute respiratory distress syndrome (PARDS). This article aims to report on the rationale behind the revised monitoring recommendations/statements from the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2).
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Yu-Qiong He, Can-Can Zhou, Lu-Yao Yu, Liang Wang, Jiu-Ling Deng, Yu-Long Tao, Feng Zhang, Wan-Sheng Chen
Summary: ALI and ARDS are common life-threatening lung diseases with high mortality rates, but there is still a lack of effective pharmacological therapies. Developing new drugs for therapy of ALI/ARDS is in great demand, as natural compounds have shown potential therapeutic effects and may also be helpful for treatment of COVID-19.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Respiratory System
Pearl Toy, Mark R. Looney, Mark Popovsky, Miodrag Palfi, Gosta Berlin, Catherine E. Chapman, Paula Bolton-Maggs, Michael A. Matthay
Summary: Transfusion-related acute lung injury (TRALI) is a condition characterized by acute respiratory distress syndrome (ARDS) after blood transfusion, often associated with donor leukocyte antibodies or plasma from multiparous donors. While there have been successful measures to reduce TRALI, there are still unanswered questions regarding non-antibody TRALI mechanisms, the impact of blood products on ARDS in massive transfusion patients, and accurate diagnosis of TRALI.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Multidisciplinary Sciences
Xiaoting Yang, Jing Wang, Wei Liu
Summary: In this study, molecular markers associated with type II alveolar epithelial cell injury in acute lung injury (ALI) were identified using bioinformatics methods. The results provide new insights for the diagnosis and treatment of ALI/ARDS.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jie Zhao, Ningxin Zhen, Qichao Zhou, Jian Lou, Wei Cui, Gensheng Zhang, Baoping Tian
Summary: Acute respiratory distress syndrome (ARDS) is a life-threatening condition in critically ill patients with unclear mechanisms. Neutrophil extracellular traps (NETs) released by activated neutrophils have a critical role in inflammatory injury. This study investigated the role of NETs and the underlying mechanism in acute lung injury (ALI). The findings suggest that targeting cGAS-STING may be a potential therapeutic approach for ARDS/ALI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alexis White, Zhengke Wang, Xing Wang, Michelle King, Cynthia Guo, Chris Mantsounga, Alfred Ayala, Alan R. Morrison, Gaurav Choudhary, Frank Sellke, Eboni Chambers, Lorraine B. Ware, Sharon Rounds, Qing Lu
Summary: Cigarette smoke exposure increases the incidence and severity of acute respiratory distress syndrome (ARDS), but the mechanisms are unclear. This study found that cigarette smoke impairs mitophagy flux and exacerbates mitochondrial damage and NLRP3 inflammasome activation, leading to increased acute lung injury. Inhibition of inflammasome or downstream component IL-1 beta attenuates the cigarette smoke-induced lung injury.
Article
Cell Biology
Covadonga Huidobro, Paula Martin-Vicente, Cecilia Lopez-Martinez, Ines Alonso-Lopez, Laura Amado-Rodriguez, Irene Crespo, Guillermo M. Albaiceta
Summary: Acute lung injury can lead to respiratory failure and death, with current treatment relying on supportive measures and mechanical ventilation. Research has focused on molecular and cellular pathways to find new approaches to prevent and treat this condition, with cellular senescence being a potential factor.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Letter
Critical Care Medicine
Luciano Gattinoni, John J. Marini, Luigi Camporota
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Letter
Critical Care Medicine
Luigi Camporota, Luciano Gattinoni, John J. Marini
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Editorial Material
Critical Care Medicine
Thomas Langer, Serena Brusatori, Luciano Gattinoni
INTENSIVE CARE MEDICINE
(2022)
Editorial Material
Critical Care Medicine
Luciano Gattinoni, John J. Marini
INTENSIVE CARE MEDICINE
(2022)
Letter
Respiratory System
Mattia Busana, Luigi Camporota, Luciano Gattinoni
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Critical Care Medicine
Luciano Gattinoni, Silvia Coppola, Luigi Camporota
INTENSIVE CARE MEDICINE
(2022)
Letter
Respiratory System
Mattia Busana, Luigi Camporota, Luciano Gattinoni
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Physiology
David C. Berger, Lena Zwicker, Kay Nettelbeck, Daniela Casoni, Paul Phillipp Heinisch, Hansjorg Jenni, Matthias Haenggi, Luciano Gattinoni, Kaspar F. Bachmann
Summary: Assessment of native cardiac output during extracorporeal circulation is challenging. This study evaluated a modified Fick principle for accurately measuring cardiac output under different conditions. The findings provide important insights for understanding veno-arterial extracorporeal membrane oxygenation (V-A ECMO).
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Anesthesiology
Simone Gattarello, Silvia Coppola, Elena Chiodaroli, Tommaso Pozzi, Luigi Camporota, Leif Saager, Davide Chiumello, Luciano Gattinoni
Summary: This study assessed lung mechanics in nonintubated patients with COVID-19 pneumonia and found that patients in the treatment escalation group had higher respiratory rate, tidal volume, and mechanical power ratio compared to the no-treatment escalation group. Mechanical power, its ratio, and pressure-rate index showed the highest association with the clinical outcome.
Editorial Material
Anesthesiology
Simone Gattarello, Luigi Camporota, Luciano Gattinoni
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2023)
Letter
Critical Care Medicine
Tommaso Pozzi, Francesca Collino, Serena Brusatori, Federica Romitti, Mattia Busana, Onnen Moerer, Luigi Camporota, Davide Chiumello, Silvia Coppola, Luciano Gattinoni
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Critical Care Medicine
Serena Brusatori, Carmelo Zinnato, Tommaso Pozzi, Luigi Camporota, John J. Marini, Luciano Gattinoni
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Luciano Gattinoni, Francesca Collino, Luigi Camporota
INTENSIVE CARE MEDICINE
(2023)
Article
Physiology
Rosanna D'Albo, Federica Romitti, Luigi Camporota, Onnen Moerer, Mattia Busana, Luciano Gattinoni
Summary: The conditions of temperature, pressure, and saturation in which respiratory gas volumes are expressed are often ignored in clinical practice. This study investigates the effects of gas volume corrections on key respiratory and metabolic variables, and the possible clinical consequences. The findings suggest that gas volume corrections are mostly relevant when assessing CO2 clearance, and knowing when the appropriate corrections are needed allows for a better understanding of patients' clinical conditions and tailored treatment.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Editorial Material
Critical Care Medicine
Luciano Gattinoni, Giuseppe Citerio, Arthur S. Slutsky
INTENSIVE CARE MEDICINE
(2023)