Article
Medicine, General & Internal
Jing Huang, Fengping Qiu, Huiqi Zhang, Xiangli Shen, Xia Lin
Summary: This study retrospectively analyzed the clinical data of 73 patients with multiple myeloma (MM) complicated with acute kidney injury (AKI). It was found that continuous veno-venous hemofiltration (CVVH) combined with hemoperfusion was more effective than simple chemotherapy. The observation group had a significantly higher total efficacy, lower renal function indexes, and lower levels of serum globulin and erythrocyte sedimentation rate (ESR) compared to the control group. The results suggest that combining CVVH and hemoperfusion improves treatment efficacy, promotes renal function recovery, and improves serum globulin and ESR levels.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Critical Care Medicine
Paul Koeglberger, Sebastian J. Klein, Georg Franz Lehner, Romuald Bellmann, Andreas Peer, Daniel Schwaerzler, Michael Joannidis
Summary: This study evaluated the effectiveness of switching from high to low bicarbonate replacement fluid in alkalotic critically ill patients undergoing CVVH with RCA. The switch led to a significant decrease in serum HCO3- concentration and base excess, which remained stable up to 72 hours later.
ANNALS OF INTENSIVE CARE
(2021)
Article
Hematology
Simon Baylis, Rahul Costa-Pinto, Sarah Hodgson, Rinaldo Bellomo, Ian Baldwin
Summary: In this case, the combination of CRRT and hemoperfusion led to a significant reduction in CBZ levels, removing close to 35 mg/h of the drug and achieving a 50% reduction in CBZ level from 16 mg/L to 8 mg/L over 3 hours.
BLOOD PURIFICATION
(2022)
Article
Immunology
Andrew S. Jarrell, Jessica R. Crow, Sara E. Strout, Rachel M. Kruer, Lindsey P. Toman, Maria Dioverti-Prono, Laura Lees, Robin K. Avery, Mark A. Marzinke
Summary: Valganciclovir 450 mg enterally every 24 hours achieved ganciclovir trough concentrations >= 0.60 mu g/mL in most patients on CVVHD, similar to those reported with intravenous ganciclovir for prophylaxis in this population. Neutropenia did not occur in the study period. Thrombocytopenia was common and likely multifactorial.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Engineering, Biomedical
Fiorenza Ferrari, Miriam Manera, Gianluca Villa, Annalisa De Silvestri, Nicholas Simone Manuel Bianchi Bosisio, Angelo Guglielmi, Giovanni Mazza, Costanza Colombo, Luigi D'Auria, Rampino Teresa, Mirko Belliato
Summary: We analyzed the interaction between continuous renal replacement therapy (CRRT) machine and extracorporeal membrane oxygenation (ECMO) machine, and found that our configuration of connecting the CRRT machine to the ECMO machine was safe and effective.
Article
Nutrition & Dietetics
Simon Wechselberger, Friederike Compton, Johannes Schilling
Summary: Malnutrition and overfeeding can negatively affect clinical outcomes in critically ill patients. Continuous veno-venous hemodialysis (CVVHD) with regional citrate anticoagulation (RCA) using trisodium citrate 4% (TSC) may have a role in nutrient disposition in ICU patients. However, the metabolic contribution of lactate, glucose, and citrate in CVVHD appears to be negligible.
Article
Hematology
Benjamin Sansom, Shyamala Sriram, Jeffrey Presneill, Rinaldo Bellomo
Summary: A study conducted in a hospital in Australia showed that low blood flow CVVHD performed better in terms of alarm rates, while maintaining azotaemic control and circuit patency, reducing the workload of bedside clinicians. There were no significant differences between the two treatment methods in terms of azotaemic control and filter life.
BLOOD PURIFICATION
(2022)
Article
Urology & Nephrology
Fang Wang, Min Zhang, Xu Li, Xiankun Sun, Xuanchen He, Mingjing Guan, Zhiwen Chen, Li Lin, Xue Tang, Ling Zhang
Summary: This study aimed to evaluate the effect of three dilution modes (pre-dilution, post-dilution, and pre- to post-dilution) on circuit lifespan during continuous veno-venous hemodiafiltration (CVVHDF). The results showed that the pre- to post-dilution mode significantly prolonged circuit lifespan compared with the pre-dilution and post-dilution modes, but there were no significant differences in terms of changes in serum creatinine and blood urea nitrogen levels, admission day, and 28-day all-cause mortality.
SEMINARS IN DIALYSIS
(2023)
Article
Medicine, General & Internal
Antal Szabo-Biczok, Gabriella Varga, Zoltan Varga, Gabor Bari, Gyongyver Vigyikan, Amos Gajda, Noemi Vida, Adam Hodoniczki, Attila Rutai, Laszlo Juhasz, Anna Naszai, Mate Gyongyosi, Sandor Turkevi-Nagy, Daniel Erces, Mihaly Boros
Summary: This study aimed to establish a large animal model of vv-ECMO to study the pathomechanism of complications and investigate renal reactions. The results showed significant renal dysfunction, structural damage, and impaired mitochondrial function in the vv-ECMO group.
FRONTIERS IN MEDICINE
(2022)
Review
Pediatrics
Susan D. Martin, Marc B. Lande, Joseph D. Kuebler, Jill M. Cholette
Summary: Fontan palliation relies on low pulmonary vascular resistance for maintaining pulmonary blood flow and oxygenation. However, positive pressure ventilation and peritoneal dialysis during the day can have detrimental effects on systemic venous pressure and pulmonary blood flow.
FRONTIERS IN PEDIATRICS
(2022)
Article
Cell Biology
Andreas Margraf, Chang Liu, Mira Kullmar, Melanie Meersch, Jan Rossaint, Alexander Zarbock
Summary: Acute kidney injury significantly affects leukocyte function during CVVH treatment, impairing selectin-mediated slow rolling and chemokine-induced arrest. Systemic heparin and local citrate anticoagulants have no differential effect on leukocyte recruitment steps.
Article
Gastroenterology & Hepatology
Satish Chandra Yadav, Bingqiang Zhang
Summary: This study compared the effects of conventional treatment and continuous veno-venous haemofiltration (CVVH) on the prevention of pseudocyst and walled-off necrosis in severe acute pancreatitis (SAP) patients. The results showed that CVVH patients had a significantly greater decrease in various markers, and no local pancreatic complications, indicating that early CVVH may be able to effectively prevent the formation of pseudocyst and walled-off necrosis in SAP patients.
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2022)
Article
Urology & Nephrology
Willem Boer, Mathias Van Tornout, Margot Vander Laenen, Kim Engelen, Ingrid Meex, Philippe Jorens
Summary: The study found that CathPR led to a significant decrease in PfiCA and an increase in PfCC, affecting calcium clearance, especially with the increase in citrate concentration. In citrate CVVH, CathPR in dysfunctional catheters should be limited in duration and monitored closely.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Infectious Diseases
Mark E. Murphy, Sonya Tang Girdwood, Jennifer L. Goldman, Marc H. Scheetz, Kevin J. Downes
Summary: This study supports the use of AUC(24) monitoring for vancomycin in children, arguing that trough levels are inadequate substitutes for AUC(24) and that vancomycin-associated nephrotoxicity has significant consequences, especially for high-risk children who deserve targeted monitoring.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Critical Care Medicine
Kevin Roedl, Silvia De Rosa, Marlene Fischer, Josephine Braunsteiner, Christian Schmidt-Lauber, Dominik Jarczak, Tobias B. Huber, Stefan Kluge, Dominic Wichmann
Summary: This retrospective analysis investigates critically ill COVID-19 patients requiring vv-ECMO and their risk of acute kidney injury (AKI) and need for kidney replacement therapy (RRT). The study finds that 45% of the patients developed early AKI and 70% required RRT. Younger age and higher disease severity were identified as risk factors for early AKI. The study also suggests that the mortality rates were comparable between patients receiving RRT and those not receiving RRT.
ANNALS OF INTENSIVE CARE
(2023)