Multiscale modeling of cellular systems in biology

Here we review eight different multiscale modeling efforts dealing with cellular systems in biology. The first two models focus on collagen based tissue, one dealing with the biomechanical properties of the tissue and the other focusing on how the dermis is remodeled in scar tissue formation. The next two models deal with first avascular tumor growth and then the role of the vasculature in tumor growth. We then consider two models which use the Immersed Boundary method to model tissue properties and cell-cell adhesion. Finally we conclude with two models with treatments of the Cellular Potts Model. The first models somitogenisis in the chick and the second links the Cellular Potts Model with the Keller-Segel model. (C) 2009 Elsevier Ltd. All rights reserved.