Article
Clinical Neurology
Luke A. Johnson, Joshua E. Aman, Ying Yu, David Escobar Sanabria, Jing Wang, Meghan Hill, Rajiv Dharnipragada, Remi Patriat, Mark Fiecas, Laura Li, Lauren E. Schrock, Scott E. Cooper, Matthew D. Johnson, Michael C. Park, Noam Harel, Jerrold L. Vitek
Summary: Studies have shown that high-frequency oscillations in the internal globus pallidus (GPi) increase during movement in Parkinson's patients and are negatively correlated with bradykinesia. High-frequency oscillations were observed in monkeys after the induction of parkinsonism with the neurotoxin 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine. Spontaneous high-frequency oscillations in patients were significantly reduced when on medication.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
James A. Jones, Matthew H. Higgs, Erick Olivares, Jacob Pella, Charles J. Wilson
Summary: Autonomously firing GABAergic neurons in the external globus pallidus (GPe) form a local synaptic network. Silencing the firing of PV+ GPe neurons increases the firing rate and regularity of PV- neurons, while silencing Npas1+ GPe neurons has no significant effect on Npas1- neuron firing. Spontaneous GABAergic synaptic input blockade reproduces the effects of silencing PV+ neuron firing. Furthermore, as few as 5 unitary inputs can cause large increases in firing irregularity in GPe neurons.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Bing Hu, Minbo Xu, Zhizhi Wang, Danhua Jiang, Dingjiang Wang, Dongmei Zhang
Summary: Excessive synchronous oscillation activities in the brain are a key pathological feature of Parkinson's disease, and the mechanism behind it is still unclear. This study uses a STN-GPe mean-field model to explore the onset mechanism of Parkinson's oscillation and finds that various oscillation frequency bands can appear in the network. In addition to coupling weight between STN and GPe, delay is also a critical factor affecting oscillatory activities.
COGNITIVE NEURODYNAMICS
(2021)
Article
Neurosciences
Alberto Averna, Sara Marceglia, Alberto Priori, Guglielmo Foffani
Summary: This study investigates the dynamics of spontaneous amplitude modulation (AM) and frequency modulation (FM) in Parkinson's disease patients. The results show a negative correlation between AM and FM, which changes after levodopa administration. AM and FM separately and jointly encode the dopaminergic state in patients, with FM being more informative than AM.
NPJ PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Alberto Averna, Sara Marceglia, Mattia Arlotti, Marco Locatelli, Paolo Rampini, Alberto Priori, Tommaso Bocci
Summary: This study evaluated the spectrum of local field potentials (LFP) obtained from different contacts within the subthalamic nucleus in Parkinson's disease patients, and their correlations with clinical symptoms. The results showed differences in spectral patterns and correlations with motor symptoms between LFP12 and LFP03 before and after levodopa administration, suggesting potential for optimizing adaptive deep brain stimulation protocols for Parkinson's disease.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yunjie Rong, Zhifeng Xu, Ye Zhu, Xianhai Zhang, Lingfeng Lai, Shuyi Sun, Mingyong Gao, Pi Guo, Guohua Zhang, Yiqun Geng, Xilun Ma, Shuohua Wu, Lin Yang, Zhiwei Shen, Jitian Guan
Summary: This study identified changes in iron deposition and neural microstructure in the substantia nigra as potential indicators of early-stage Parkinson's disease.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Multidisciplinary Sciences
Daniela Mirzac, Svenja L. Kreis, Heiko J. Luhmann, Gabriel Gonzalez-Escamilla, Sergiu Groppa
Summary: In this article, recent experimental and clinical studies on Parkinson's disease are reviewed, focusing on abnormal neuronal activity and pathological network oscillations and their underlying mechanisms and modulation. The aim is to enhance understanding of the progression of Parkinson's disease pathology and the timing of symptom manifestation. Mechanistic insights on the generation of aberrant oscillatory activity within the cortico-basal ganglia circuits are presented, along with discussions on the advantages, limitations, and differential applicability of available PD animal models, and suggestions for transferring knowledge on disease pathology into future research and clinical applications.
Article
Mathematical & Computational Biology
Minbo Xu, Bing Hu, Weiting Zhou, Zhizhi Wang, Luyao Zhu, Jiahui Lin, Dingjiang Wang
Summary: In this paper, a new cortex-basal ganglia model was established to study the origin mechanism of Parkinson's oscillation. The study found that the increase in discharge capacity of the nuclei can cause oscillation, while the sharp reduction in discharge rate of the nuclei can also cause oscillation. Additionally, two direct inhibitory projections from the globus pallidus external were found to significantly reduce the amplitude gap between inhibitory nuclei and excitatory nuclei.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)
Article
Clinical Neurology
Khaled Moussawi, Min Jae Kim, Sydney Baybayan, Myles Wood, Kelly A. Mills
Summary: The study investigated the behavioral responses of Parkinson's disease patients under globus pallidus internus DBS settings, revealing a negative correlation between the volume of tissue activation connected to the right prefrontal cortex and impulsivity, while greater overlap with the non-prefrontally-connected globus pallidus internus was associated with increased impulsivity.
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Geriatrics & Gerontology
Daniella B. Victorino, Jean Faber, Daniel J. L. L. Pinheiro, Fulvio A. Scorza, Antonio C. G. Almeida, Alberto C. S. Costa, Carla A. Scorza
Summary: Cross-frequency coupling (CFC) mechanisms play a central role in brain activity, and altered theta-gamma phase-amplitude coupling (PAC) may be one of the earliest EEG signatures of Alzheimer's disease (AD). This can potentially provide clues to the biophysical mechanisms underlying cognitive dysfunction in DS-AD and generate opportunities for identifying EEG-based biomarkers with diagnostic and prognostic utility in DS-AD.
Article
Neurosciences
Maximilian Scherer, Tianlu Wang, Robert Guggenberger, Luka Milosevic, Alireza Gharabaghi
Summary: Neural communication across different spatial and temporal scales is of great interest in clinical and basic science. The direct modulation index (dMI), a novel measure, provides an accurate and reliable estimate of phase-amplitude coupling (PAC), resistant to noise and suitable for small amounts of data. Comparisons with existing methods show that dMI outperforms them in estimating PAC and is robust to varying noise levels and signal lengths. Therefore, dMI allows for a reliable investigation of PAC, offering crucial insights into functional brain architecture in key contexts such as behavior and cognition.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Imran Waggan, Eero Rissanen, Jouni Tuisku, Juho Joutsa, Semi Helin, Riitta Parkkola, Juha O. Rinne, Laura Airas
Summary: This study investigated A(2A) receptor availability in the striatum and pallidum of early- and moderate-stage PD patients without dyskinesias. The results showed regional and disease stage-dependent changes in A(2A) receptor signaling in PD pathophysiology and in response to dopaminergic medication.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Michael De Pretto, Michael Mouthon, Ines Debove, Claudio Pollo, Michael Schuepbach, Lucas Spierer, Ettore A. Accolla
Summary: The study found no behavioral effects of deep brain stimulation of the subthalamic nucleus or internal globus pallidus on proactive inhibition in Parkinson's disease patients, despite an overall improvement in motor performance with subthalamic nucleus stimulation. The results suggest a partly segregated network for proactive inhibition in the subthalamic nucleus group, with a preferential recruitment of the indirect pathway.
HUMAN BRAIN MAPPING
(2021)
Article
Medicine, Research & Experimental
Alberto Averna, Mattia Arlotti, Manuela Rosa, Stephan Chabardes, Eric Seigneuret, Alberto Priori, Elena Moro, Sara Meoni
Summary: The study evaluated the correlation between pallidal local field potentials and cortical oscillations in patients with dystonia. It found that voluntary movements and gait suppressed the coherence between GPi-LFPs-cortical-EEG, impacting EEG and LFPs low frequency activity differently.
Article
Clinical Neurology
Bethany J. Stieve, Thomas J. Richner, Chris Krook-Magnuson, Theoden Netoff, Esther Krook-Magnuson
Summary: This study explores the impact of different stimulation parameters on seizure outcomes through electrical stimulation of the cerebellum in a mouse model of temporal lobe epilepsy. By using Bayesian optimization and data-driven methods, the study identifies effective intervention settings and emphasizes the importance of specific stimulation parameters for successful cerebellar-targeted intervention.
Article
Biochemistry & Molecular Biology
Jennifer L. Zick, David A. Crowe, Rachael K. Blackman, Kelsey Schultz, David W. Bergstrand, Adele L. DeNicola, Russell E. Carter, Timothy J. Ebner, Lorene M. Lanier, Theoden Netoff, Matthew Chafee
Summary: Schizophrenia is caused by a variety of factors, but they all affect the prefrontal cortex in similar ways. The specific malfunctions in prefrontal circuits at the cellular and synaptic levels are not yet known. This study found that different manipulations in monkeys and mice produced convergent pathophysiological effects on prefrontal local circuits, suggesting a potential link between spike timing and synaptic connectivity as a functional vulnerability for the development of schizophrenia.
Article
Engineering, Biomedical
Renata Saha, Sadegh Faramarzi, Robert P. Bloom, Onri J. Benally, Kai Wu, Arturo di Girolamo, Denis Tonini, Susan A. Keirstead, Walter C. Low, Theoden Netoff, Jian-Ping Wang
Summary: This study aimed to investigate the effect of micromagnetic stimulation on hippocampal neurons using a single microcoil prototype called MagPen. The results showed that MagPen could successfully stimulate the CA3 region and induce excitatory post synaptic potential (EPSP) in the CA1 region.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Neurosciences
Evan M. Dastin-van Rijn, Seth D. Konig, Danielle Carlson, Vasudha Goel, Andrew Grande, Donald R. Nixdorf, Sarah Benish, Alik S. Widge, Ziad Nahas, Michael C. Park, Tay I. Netoff, Alexander B. Herman, David P. Darrow
Summary: Central pain disorders are clinically challenging to treat, but a personalized approach using Bayesian optimization has shown promise. In this case report, simultaneous stimulation of the motor cortex and dorsolateral prefrontal cortex successfully reduced the patient's pain without side effects.
Letter
Clinical Neurology
Joyce Chelangat Bore, Brett Campbell, Hanbin Cho, Francesco Pucci, Raghavan Gopalakrishnan, Andre Machado, Kenneth Baker
Article
Neurosciences
Raghavan Gopalakrishnan, David A. Cunningham, Olivia Hogue, Madeleine Schroedel, Brett A. Campbell, Ela B. Plow, Kenneth B. Baker, Andre G. Machado
Summary: The robust connections between the cerebellum and contralateral sensorimotor cerebral hemisphere play an important role in human behavior. The reduction of cerebellar metabolism due to damage to the sensorimotor cortex is related to poor rehabilitative outcomes. Understanding the cerebellar physiology and cortico-cerebellar coherence (CCC) after stroke may help in developing techniques for motor rehabilitation. The study found strong coupling between the ipsilesional cortex and the cerebellar dentate nucleus in the low beta band during motor control, supporting the use of the cerebello-thalamo-cortical pathway for neuromodulation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Olivia Hogue, Tucker Harvey, Dena Crozier, Claire Sonneborn, Abagail Postle, Hunter Block-Beach, Eashwar Somasundaram, Francis J. May, Monica Snyder Braun, Felicia L. Pasadyn, Khandi King, Casandra Johnson, Mary A. Dolansky, Nancy A. Obuchowski, Andre G. Machado, Kenneth B. Baker, Jill S. Barnholtz-Sloan
Summary: This study rigorously evaluated statistical choices and reporting in published controlled experiments on motor rehabilitation in mice or rats. The majority of articles failed to account for data non-independence and mid-treatment animal attrition, treated ordinal variables as continuous, did not mention outliers, and concealed the distribution of data in plots. Journal rank or reporting requirements did not affect statistical choices and transparency.
Article
Engineering, Biomedical
Scott Stanslaski, Hafsa Farooqi, David Escobar Sanabria, Theoden Ivan Netoff
Summary: This study presents a hardware-in-the-loop testing framework that uses computational models to simulate pathological neural dynamics for testing adaptive deep brain stimulation (DBS) devices. The framework allows for the validation of device functionality by simulating the effects of stimulation on neural dynamics in a saline tank. The proposed testing procedure helps ensure the correctness and robustness of adaptive DBS devices before animal and human testing.
JOURNAL OF MEDICAL DEVICES-TRANSACTIONS OF THE ASME
(2022)
Article
Neurosciences
Joyce Chelangat Bore, Carmen Toth, Brett A. Campbell, Hanbin Cho, Francesco Pucci, Olivia Hogue, Andre G. Machado, Kenneth B. Baker
Summary: Parkinson's disease, a neurological disorder characterized by motor symptoms, is found to be associated with changes in network connectivity. The study shows increased power and connectivity in the brain with disease progression, suggesting a possible role of network dysfunction in the manifestation of the disease.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Rehabilitation
Tonya L. Rich, Greg Voss, Stuart Fairhurst, Mary Matsumoto, Steven Brielmaier, Karl Koester, Theoden Netoff, Andrew H. Hansen, John E. Ferguson
Summary: This study describes the design and testing of a novel sensor system for measuring distal end weight bearing in prosthetic sockets and alerting users of poor socket fit. The results show consistent relationships between the sensor measurements and socket fit, and users expressed interest in the device, highlighting its potential benefits during early prosthesis training.
DISABILITY AND REHABILITATION
(2023)
Article
Medicine, Research & Experimental
Timothy R. Deer, Jason E. Pope, Steven M. Falowski, Julie G. Pilitsis, Corey W. Hunter, Allen W. Burton, Allison T. Connolly, Paul Verrills
Summary: This study retrospectively analyzed clinical data of Medicare beneficiaries who underwent neurostimulator implants in outpatient hospitals, and found that both primary cell (PC) and rechargeable cell (RC) batteries have similar clinical longevity. The assumption that RC batteries have longer battery life has been challenged by this study, and clinicians should consider individual factors when choosing between PC and RC devices.
Review
Clinical Neurology
James Flanary, Sam Daly, Caitlin Bakker, Alexander B. Herman, Michael C. Park, Robert McGovern, Thaddeus Walczak, Thomas Henry, Theoden Netoff, David P. Darrow
Summary: Visual review of intracranial electroencephalography (iEEG) is crucial for defining the zone of resection for epilepsy surgery. However, the reliability of visual review as a reference standard is still limited. This systematic literature review examines the existing evidence on the reliability of visual review and its implications for algorithm accuracy. The study found that the reliability of iEEG interpretation significantly affects the accuracy of algorithms in predicting the seizure onset zone (SOZ).
Article
Medicine, Research & Experimental
Brandon K. Hoglund, Claire A. Zurn, Lauren R. Madden, Caleb Hoover, Julia P. Slopsema, David Balser, Ann Parr, Uzma Samadani, Matthew D. Johnson, Theoden I. Netoff, David P. Darrow
Summary: This study investigates the spatial specificity of stimulation-induced muscle activation patterns for targeted muscle groups in individuals with chronic spinal cord injury. The results suggest that cathodic stimulation provides uniform laterality targeting, while variation in rostral/caudal stimulation has limited effects on most muscle groups. Oblique stimulation improved stimulation responses compared to horizontal configurations. These findings have important implications for tailored targeting of muscle groups in the rehabilitation of chronic spinal cord injury.
Article
Biochemistry & Molecular Biology
Kenneth B. B. Baker, Ela B. B. Plow, Sean Nagel, Anson B. B. Rosenfeldt, Raghavan Gopalakrishnan, Cynthia Clark, Alexandria Wyant, Madeleine Schroedel, John Ozinga, Sara Davidson, Olivia Hogue, Darlene Floden, Jacqueline Chen, Paul J. J. Ford, Lauren Sankary, Xuemei Huang, David A. A. Cunningham, Frank P. P. DiFilippo, Bo Hu, Stephen E. E. Jones, Francois Bethoux, Steven L. L. Wolf, John Chae, Andre G. Machado
Summary: This study investigated the effects of deep brain stimulation combined with physical rehabilitation on upper-extremity impairment in stroke patients. The results showed that deep brain stimulation promoted functional reorganization and improved upper-extremity function. These findings support the use of deep brain stimulation for late-stage neuroplasticity modulation and highlight the need for larger clinical trials.
Review
Neurosciences
Jakov Tiefenbach, Leonardo Favi Bocca, Olivia Hogue, Neil Nero, Kenneth B. Baker, Andre G. Machado
Summary: This study evaluated the incidence and risk factors of intracranial bleeding in deep brain stimulation surgery. The results showed that the incidence of intracranial bleeding per each patient was 2.5% and per each implanted lead was 1.4%. Older patients had a higher risk of hemorrhage.
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2023)