Article
Medicine, General & Internal
Anthony C. Gordon, Farah Al-Beidh, Kathryn M. Rowan, Alistair D. Nichol, Yaseen M. Arabi, Djillali Annane, Ahi Beane, Wilma Van Bentum-Puijk, Lindsay R. Berry, Zahra Bhimani, Marc J. M. Bonten, Charlotte A. Bradbury, Frank M. Brunkhorst, Adrian Buzgau, Allen C. Cheng, Michelle A. Detry, Eamon J. Duffy, Lise J. Estcourt, Mark Fitzgerald, Herman Goossens, Rashan Haniffa, Alisa M. Higgins, Thomas E. Hills, Christopher M. Horvat, Francois Lamontagne, Patrick R. Lawler, Helen L. Leavis, Kelsey M. Linstrum, Edward Litton, Elizabeth Lorenzi, John C. Marshall, Florian B. Mayr, Daniel F. McAuley, Anna McGlothlin, Shay P. McGuinness, Bryan J. McVerry, Stephanie K. Montgomery, Susan C. Morpeth, Srinivas Murthy, Katrina Orr, Rachael L. Parke, Jane C. Parker, Asad E. Patanwala, Ville Pettill, Emma Rademaker, Marlene S. Santos, Christina T. Saunders, Christopher W. Seymour, Manu Shankar-Hari, Wendy L. Sligl, Alexis F. Turgeon, Anne M. Turner, Frank L. van de Veerdonk, Ryan Zarychanski, Cameron Green, Roger J. Lewis, Derek C. Angus, Colin J. McArthur, Scott Berry, Steve A. Webb, Lennie P. G. Derde
Summary: Interleukin-6 receptor antagonists tocilizumab and sarilumab were found to improve outcomes, including survival, in critically ill patients with Covid-19 receiving organ support in ICUs according to an ongoing international trial. The efficacy of these treatments has been confirmed, with patients benefiting from the therapy.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Daniel C. Castro, Corinna S. Oswell, Eric T. Zhang, Christian E. Pedersen, Sean C. Piantadosi, Mark A. Rossi, Avery C. Hunker, Anthony Guglin, Jose A. Moron, Larry S. Zweifel, Garret D. Stuber, Michael R. Bruchas
Summary: The study reveals that mu-opioid peptide receptor regulates reward consumption in mice through a specific pathway from the dorsal raphe to the nucleus accumbens. Inhibition of raphe terminals by MOPR is crucial for determining consummatory response. Activation of enkephalin-containing nucleus accumbens ensembles prior to reward consumption suggests that local enkephalin release is the source of the endogenous MOPR ligand.
Article
Pharmacology & Pharmacy
Ehsan A. Habeeb, Lena K. Tran, Melanie Z. Goodberlet, Kenneth E. Lupi, Jeremy R. DeGrado, Kevin M. Dube
Summary: This study aimed to evaluate the efficacy of enteral naloxone (NLX) versus subcutaneous methylnaltrexone (MNTX) for opioid-induced constipation (OIC) in critically ill patients. The results showed that NLX had a shorter time to first bowel movement compared to MNTX. Both NLX and MNTX were effective in treating OIC without causing reversal of analgesia. Future controlled trials are needed to further validate these findings.
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Shijia Liu, Dong-Il Kim, Tae Gyu Oh, Gerald M. Pao, Jong-Hyun Kim, Richard D. Palmiter, Matthew R. Banghart, Kuo-Fen Lee, Ronald M. Evans, Sung Han
Summary: Neurons expressing the mu-opioid receptor within the lateral parabrachial nucleus play a crucial role in opioid-induced respiratory depression (OIRD). Chemogenetic modulation of these neurons can rescue respiratory rhythms and serve as a potential therapeutic target for treating OIRD in patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Zhifeng Zhou, Huang Kuang, Yuexian Ma, Ling Zhang
Summary: COVID-19, caused by SARS-CoV-2, has high mortality in critically ill patients, and extracorporeal therapies may have a potential role in treatment.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Gastroenterology & Hepatology
Rajan Vijayaraghavan, Rakhi Maiwall, Vinod Arora, Ashok Choudhary, Jaya Benjamin, Prashant Aggarwal, Kapil Dev Jamwal, Guresh Kumar, Y. K. Joshi, Shiv K. Sarin
Summary: In this study, it was found that feed intolerance is common in ICU patients with cirrhosis, and prokinetics can help resolve this issue and improve short-term survival rates.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Keith M. Olson, Andrea L. Devereaux, Payal Chatterjee, Savanah L. Saldana-Shumaker, Amanda Shafer, Adam Plotkin, Ram Kandasamy, Alexander D. MacKerell, John R. Traynor, Christopher W. Cunningham
Summary: This study investigates the structure-activity relationships of benzylideneoxymorphone analogs in order to develop analgesics with reduced tolerance and side effects. One compound, nitro-BOM (NBOM), showed high-efficacy antinociception but also exhibited tolerance and toxicity upon repeated administration. Despite these issues, NBOM provides an important tool for understanding MOPr/DOPr pharmacology.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Gastroenterology & Hepatology
Karim Chamie, Vishnukamal Golla, Andrew T. Lenis, Patrick M. Lec, Siamak Rahman, Eugene R. Viscusi
Summary: PAMORAs, as peripherally acting mu-opioid receptor antagonists, have the potential to alleviate postoperative ileus and opioid-induced constipation by blocking peripheral effects of opioids in the gastrointestinal tract while maintaining their analgesic properties in the central nervous system. Further research is needed to explore the therapeutic potential of PAMORAs in the management of POI and postoperative OIC.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Critical Care Medicine
Karel Balihar, Jan Kotyza, Lucie Zdrhova, Jana Kozeluhova, Michal Krcma, Martin Matejovic
Summary: Motility disorders of upper gastrointestinal tract are common in critical illness and vary according to gastric emptying status. Metoclopramide reduced esophageal activities but did not affect reflux episodes in critically ill patients.
Review
Critical Care Medicine
Hasan M. Al-Dorzi, Yaseen M. Arabi
Summary: The incidence of stress-induced clinically important gastrointestinal bleeding in critically ill patients seems to be decreasing. Early enteral nutrition and proton pump inhibitors may be effective in preventing gastrointestinal bleeding, but questions remain regarding which patients are likely to benefit the most.
CURRENT OPINION IN CRITICAL CARE
(2021)
Article
Chemistry, Medicinal
Taryn Bosquez-Berger, Jessica A. Gudorf, Charles P. Kuntz, Jacob A. Desmond, Jonathan P. Schlebach, Michael S. VanNieuwenhze, Alex Straiker
Summary: The US is facing a severe increase in fatal drug overdoses, with synthetic opioids like fentanyl causing 80% of deaths. Naloxone, the only antidote for opiate overdose, struggles against these synthetic opioids. A study has found that (-)-Cannabidiol ((-)-CBD), a candidate negative allosteric modulator (NAM) for the mu opioid receptor, shows potential as a more potent NAM than naloxone. The study suggests that CBD analogs have potential for the development of next-generation antidotes for opioid overdose.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Weiguo Fan, Hualong Liu, Yang Shen, Kui Hong
Summary: This study aimed to investigate the association between proton pump inhibitors (PPIs) treatment and QT interval prolongation in critically ill patients. Analysis of ECG reports of ICU patients revealed that PPIs treatment was significantly associated with an increased risk of QT interval prolongation compared to histamine 2 receptor antagonists (H2RAs) and non-acid suppression therapy (non-AST).
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Marcela Kanova, Pavel Kohout
Summary: Serotonin plays crucial roles as a neurotransmitter in controlling brain functions and as a peripheral hormone in regulating various organs. High levels of serotonin can lead to serotonin syndrome with symptoms like altered mental status and muscle rigidity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Respiratory System
Olivier Hermine, Xavier Mariette, Raphael Porcher, Matthieu Resche-Rigon, Pierre-Louis Tharaux, Philippe Ravaud
Summary: This study aimed to determine whether anti-interleukin (IL)-6 receptors improve outcomes in critically ill patients with COVID-19 pneumonia. The results showed that anti-IL-6 receptor treatment did not significantly increase the number of patients alive without the need for noninvasive ventilation (NIV) or mechanical ventilation (MV) by day 14.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Ferenc Zador, Kornel Kiraly, Nariman Essmat, Mahmoud Al-Khrasani
Summary: This review summarizes recent data on the activation of mu opioid receptor (mu OR) by opioid agonists, including ligand recognition, signal transduction, and structural changes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Geriatrics & Gerontology
Tobias Engeroff, Lutz Vogt, Johannes Fleckenstein, Eszter Fuezeki, Silke Matura, Ulrich Pilatus, Sina Schwarz, Ralf Deichmann, Rainer Hellweg, Johannes Pantel, Winfried Banzer
AGING & MENTAL HEALTH
(2019)
Article
Neurosciences
Roberta Sclocco, Florian Beissner, Marta Bianciardi, Jonathan R. Polimeni, Vitaly Napadow
Article
Anesthesiology
Sybille Kramer, Petra Baeumler, Christian Geber, Johannes Fleckenstein, Michael Simang, Laura Haas, Gabriel Schober, Florian Pfab, Rolf-Detlef Treede, Dominik Irnich
Review
Sport Sciences
J. Fleckenstein, W. Banzer
Article
Sport Sciences
Marc Philippe, Ingo Filzwieser, Veronika Leichtfried, Cornelia Blank, Simon Haslinger, Johannes Fleckenstein, Wolfgang Schobersberger
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2019)
Article
Physiology
Marc Philippe, Hannes Gatterer, Martin Burtscher, Birgit Weinberger, Michael Keller, Beatrix Grubeck-Loebenstein, Johannes Fleckenstein, Katharina Alack, Karsten Krueger
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Ann-Christin Kortenjann, Winfried Banzer, Johannes Fleckenstein
SCIENTIFIC REPORTS
(2020)
Article
Rehabilitation
Jens Heyn, Johannes Fleckenstein
Summary: German handball referees are at risk of sports-related injuries and subsequent pain, highlighting the need for prevention programs to be developed and integrated into their routine.
BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
(2021)
Article
Geriatrics & Gerontology
Sina Gerten, Tobias Engeroff, Johannes Fleckenstein, Eszter Fuezeki, Silke Matura, Ulrich Pilatus, Lutz Vogt, Johannes Pantel, Winfried Banzer
Summary: Participating in physical activity, maintaining physical performance, and reducing sedentary behavior are beneficially associated with cognitive function in older adults. This study found that light physical activity had a positive impact on executive function, while attention and working memory were related to physical performance.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Clinical Neurology
Johannes Fleckenstein, Philipp Floessel, Tilman Engel, Laura Krempel, Josefine Stoll, Martin Behrens, Daniel Niederer
Summary: Individualized exercise treatment combined with psychological interventions has significant effects on pain and disability in patients with chronic non-specific low-back pain. Short-term treatment effects are stable and clinically important for pain reduction. Individualized exercise is more effective compared to active treatments.
Article
Psychology, Multidisciplinary
Johannes Fleckenstein, Sina Gerten, Winfried Banzer
Summary: Sleep loss is a significant issue for night-shift workers, but exercise can improve attention and consciousness. However, exercise does not have a significant impact on memory function. Further research is needed to explore the practicality and significance of exercise for night-shift workers.
BEHAVIORAL SCIENCES
(2022)
Article
Neuroimaging
Wei Shen, Yiheng Tu, Randy L. Gollob, Ana Ortiz, Vitaly Napadow, Siyi Yu, Georgia Wilson, Joel Park, Courtney Lang, Minyoung Jung, Jessica Gerber, Ishtiaq Mawla, Suk-Tak Chan, Ajay D. Wasan, Robert R. Edwards, Ted Kaptchuk, Shasha Li, Bruce Rosen, Jian Kong
NEUROIMAGE-CLINICAL
(2019)
Article
Integrative & Complementary Medicine
Taras Usichenko, Bert Wetzel, James Paul, Victor Lysenyuk, Klaus Hahnenkamp, Johannes Fleckenstein
MEDICAL ACUPUNCTURE
(2018)
Article
Sport Sciences
Pedro Delgado-Floody, Felipe Caamano-Navarrete, Javier Gonzalez Rivera, Johannes Fleckenstein, Winfried Banzer, Cristian Martinez Salazar
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2018)
Article
Health Care Sciences & Services
Melat Gebre, Anna Woodbury, Vitaly Napadow, Venkatagiri Krishnamurthy, Lisa C. Krishnamurthy, Roman Sniecinski, Bruce Crosson
JMIR RESEARCH PROTOCOLS
(2018)