Article
Environmental Sciences
Azubuike Victor Chukwuka, Fisayo C. Jerome, Adesola Hassan, Benjamin Ebonwu, Aina O. Adeogun
Summary: This study investigates the association between muscle pathologies and oxidative stress in blue crabs. The findings show that the uptake of redox-active metals in muscle tissue is related to lipid peroxidation and the prevalence of myopathies. The study also identifies severe skeletal muscle deterioration associated with parasite cysts.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Anayt Ulla, Takayuki Uchida, Yukari Miki, Kosuke Sugiura, Atsushi Higashitani, Takeshi Kobayashi, Ayako Ohno, Reiko Nakao, Katsuya Hirasaka, Iori Sakakibara, Takeshi Nikawa
Summary: Glucocorticoids can induce muscle atrophy by increasing oxidative stress, while antioxidants such as morin can mitigate this effect. The study showed that morin effectively prevented glucocorticoid-induced muscle atrophy by reducing oxidative stress.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Biochemistry & Molecular Biology
Hayden W. Hyatt, Scott K. Powers
Summary: Skeletal muscle, essential for functions like breathing and movement, is susceptible to wasting due to various factors such as chronic diseases, cancer treatment, aging, and inactivity. Mitochondrial dysfunction plays a key role in this muscle wasting process, linking it to conditions like cancer, sepsis, and aging. Future research directions in this field are crucial for understanding and addressing muscle wasting.
Article
Cardiac & Cardiovascular Systems
Hideo Nambu, Shingo Takada, Satoshi Maekawa, Junichi Matsumoto, Naoya Kakutani, Takaaki Furihata, Ryosuke Shirakawa, Takashi Katayama, Takayuki Nakajima, Katsuma Yamanashi, Yoshikuni Obata, Ippei Nakano, Masaya Tsuda, Akimichi Saito, Arata Fukushima, Takashi Yokota, Junko Nio-Kobayashi, Hironobu Yasui, Kei Higashikawa, Yuji Kuge, Toshihisa Anzai, Hisataka Sabe, Shintaro Kinugawa
Summary: Exercise intolerance in patients with heart failure is partly attributed to skeletal muscle abnormalities caused by XO-derived ROS, which can be prevented by inhibition of their production.
CARDIOVASCULAR RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Jonathan M. Memme, Mikhaela Slavin, Neushaw Moradi, David A. Hood
Summary: Periods of muscle disuse can lead to mitochondrial changes that affect muscle health and atrophy. Research has shown that abnormalities in mitochondrial quality control pathways can cause muscle atrophy due to inactivity, highlighting the need for further investigation into how mitochondria contribute to disuse-induced muscle atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Entomology
Peng Liang, Jie Ning, Wenlu Wang, Pu Zhu, Lianyou Gui, Wen Xie, Youjun Zhang
Summary: This study found that the antioxidant enzymes in Bemisia tabaci MED can help the insect adapt to long-term and short-term high temperatures by eliminating excessive reactive oxygen species (ROS).
Article
Cell Biology
Giulia Pozzi, Valentina Presta, Elena Masselli, Giancarlo Condello, Samuele Cortellazzi, Maria Luisa Arcari, Cristina Micheloni, Marco Vitale, Giuliana Gobbi, Prisco Mirandola, Cecilia Carubbi
Summary: Reactive oxygen species (ROS) are key players in physiological processes and can affect myogenic differentiation. Protein kinase C epsilon (PKCe) is involved in muscle stem cell differentiation and skeletal muscle regeneration. PKCs have a role in redox biology and may regulate ROS production. Our study suggests that PKCe is a molecular link between redox homeostasis and myogenic differentiation. We found that PKCe interacts with Nrf2 to activate antioxidant signaling, preventing ROS accumulation and promoting myogenic differentiation.
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Article
Cell Biology
Paige J. Chambers, Emma S. Juracic, Val A. Fajardo, A. Russell Tupling
Summary: Sarcolipin (SLN) is a small regulatory protein that inhibits the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) pump and plays a direct role in altering skeletal muscle relaxation and energy expenditure. The expression of SLN is dynamic during muscle adaptation and its upregulation can have both beneficial and detrimental effects on muscle health. The underlying mechanisms of SLN upregulation may involve a positive feedback loop with Ca2+ signaling molecules.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anne Abot, Steven Fried, Patrice D. Cani, Claude Knauf
Summary: The role of reactive oxygen/nitrogen species as friend or foe messengers in the body is well studied, with their effects depending on concentration in tissues. The intestine, affected by oxidation and inflammation, plays a crucial role in diabetic symptoms. Controlling levels of intestinal reactive oxygen/nitrogen species is a complex balance with potential therapeutic implications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Mark R. Viggars, Hazel Sutherland, Christopher P. Cardozo, Jonathan C. Jarvis
Summary: Transcriptional assessments of identical nerve-stimulated resistance exercise in mice and rats reveal concordant and discordant gene regulation and pathways related to muscle growth.
Article
Chemistry, Physical
Juan Xie, Penghui Bai, Chenjie Wang, Ning Chen, Weifeng Chen, Ming Duan, Hu Wang
Summary: This study investigates the effect of doping SrTiO3 with an extremely low concentration of NiP on the catalytic activity of water splitting under visible light irradiation. It is found that the transformation of oxygen species and the construction of reactive lattice oxygen play a crucial role in improving the hydrogen generation performance. Adjusting the ratio of different oxygen species is an effective strategy to fabricate high-performance photocatalysts for H-2 evolution.
ACS APPLIED ENERGY MATERIALS
(2022)
Review
Engineering, Biomedical
Shiyong Zhang, Liying Wang, Yunze Kang, Jun Wu, Ziji Zhang
Summary: Reactive oxygen species (ROS) have significant roles in physiological and pathophysiological processes. Recent studies have shown that ROS plays a crucial role in the development and progression of osteoarthritis (OA) by mediating extracellular matrix degradation, mitochondrial dysfunction, chondrocyte apoptosis, and OA progression. Nanomaterials with ROS-scavenging ability and antioxidant effects have shown promising results in OA treatment. However, current research on nanomaterials as ROS scavengers for OA is not uniform, and the timing and potential of their clinical use remain inconsistent. This review aims to provide a reference for further studies and promote the early clinical use of nanomaterials for OA treatment.
ACTA BIOMATERIALIA
(2023)
Article
Nutrition & Dietetics
Luchuanyang Sun, Nobuyuki Miyaji, Min Yang, Edward M. Mills, Shigeto Taniyama, Takayuki Uchida, Takeshi Nikawa, Jifeng Li, Jie Shi, Katsuyasu Tachibana, Katsuya Hirasaka
Summary: The study demonstrated that astaxanthin (AX) has protective effects on muscle atrophy by preventing loss of muscle weight and suppressing muscle fiber size decrease, hydrogen peroxide production increase, and downregulation of mitochondrial respiratory chain complexes. AX also promoted mitochondrial biogenesis and inhibited mitochondrial reactive oxygen species production and apoptosis, ultimately preventing muscle atrophy.
Review
Engineering, Biomedical
Xiaohua Zheng, Yilan Jin, Xiao Liu, Tianqing Liu, Weiqi Wang, Haijun Yu
Summary: Reactive species-based cancer therapies have gained significant attention for their simplicity, controllability, and efficacy. Utilizing nanomaterials for photo-controlled generation of highly reactive radical species is a promising approach for cancer treatment, showing potential synergistic effects with other therapeutic modalities.
BIOACTIVE MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Silvia Scaricamazza, Illari Salvatori, Susanna Amadio, Valentina Nesci, Alessio Torcinaro, Giacomo Giacovazzo, Aniello Primiano, Michela Gloriani, Niccolo Candelise, Luisa Pieroni, Jean-Philippe Loeffler, Frederique Rene, Cyril Quessada, Tesfaye W. Tefera, Hao Wang, Frederik J. Steyn, Shyuan T. Ngo, Gabriella Dobrowolny, Elisa Lepore, Andrea Urbani, Antonio Musaro, Cinzia Volonte, Elisabetta Ferraro, Roberto Coccurello, Cristiana Valle, Alberto Ferri
Summary: The therapeutic potential of the multi-target drug trimetazidine was evaluated in SOD1(G93A) mice. The results showed that trimetazidine delayed disease progression, improved motor function and metabolism, and increased overall survival of the mice.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ester Sara Di Filippo, Franco Checcaglini, Giorgio Fano-Illic, Stefania Fulle
Summary: In order to respond to changes in the environment and carry out necessary metabolic functions, cells require a functional control center. This review identifies the mitochondrion as such a control center, where messengers like H2O2, Ca2+, and Zn2+ collaborate to activate adaptive response mechanisms. By exchanging information, these messengers generate a holistic response of the cell.
Article
Cell & Tissue Engineering
Flavia Forconi, Ludovica Apa, Simona Pisu, Irene Casola, Antonio Musaro, Emanuele Rizzuto, Zaccaria Del Prete
Summary: This study proposes a novel technique and parameter to assess the functionality of the neuromuscular junction (NMJ) under isotonic conditions, including fatigue, providing important insights into neuronal signal transmission. This technique can be applied to other animal models to investigate muscle-nerve impairments in other neurodegenerative pathologies.
CELLULAR AND MOLECULAR BIOENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Silvia Sancilio, Sara Nobilio, Antonio Giulio Ruggiero, Ester Sara Di Filippo, Gianmarco Stati, Stefania Fulle, Rosa Grazia Bellomo, Raoul Saggini, Roberta Di Pietro
Summary: This study demonstrates for the first time the direct effects of mechanical vibrations on human satellite cells. These effects vary between young and aged samples, with cells from young subjects exhibiting a proliferative response and cells from aged subjects exhibiting a differentiative response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Francesco Maria Achille Consoli, Yara Bernaldo de Quiros, Manuel Arbelo, Stefania Fulle, Marco Marchisio, Mario Encinoso, Antonio Fernandez, Miguel A. Rivero
Summary: Cetaceans are marine mammals that have evolved to adapt to life in the water. However, the characteristics of their bone tissue are still not well-studied. This study used computed tomography to measure the bone radiodensity of cetacean humerus and compared it between different species and within the same species. The results showed significant differences in bone density between different types of bone and different portions of the humerus. These differences were also observed between species with different diving and swimming habits. This technique can be used to compare and understand the unique adaptations of cetaceans in the aquatic ecosystem.
Editorial Material
Biochemistry & Molecular Biology
Giorgio Fano-Illic, Stefania Fulle
Review
Cell Biology
Laura Forcina, Claudio Franceschi, Antonio Musaro
Summary: IL-6 is a pleiotropic cytokine with dual and sometimes opposite actions, depending on its intensity and duration of release. It can have anti-inflammatory, antioxidant, and pro-myogenic effects at low levels but can induce pro-inflammatory, pro-oxidant, and pro-fibrotic responses at increased systemic concentrations. The role of IL-6 in aging-related diseases and its involvement in the switch from physiological aging to age-related diseases, such as chronic inflammation and oxidative stress, is not fully understood.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Paolo Carpineto, Ester Sara Di Filippo, Agbeanda Aharrh Gnama, Danilo Bondi, Carla Iafigliola, Arturo Maria Licata, Stefania Fulle
Summary: Proliferative vitreoretinopathy (PVR) is a condition characterized by abnormal scarring within the eye that can occur after retinal detachment. This study aimed to investigate the expression profiles of specific microRNAs (miRNAs) in subretinal fluid collected from patients with retinal detachment and to evaluate their potential correlation with PVR risk factors. The results showed a positive association between the expression of miR-21 and miR-34 and the duration of retinal detachment symptoms, as well as a trend of decreased expression of miR-146a in patients who developed PVR. This suggests that analyzing miRNA expression in subretinal fluid could provide insights into the development of PVR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Felice Lorusso, Antonio Scarano, Stefania Fulle, Luca Valbonetti, Rosa Mancinelli, Ester Sara Di Filippo
Summary: This study analyzed the effects of three natural compounds (resveratrol, curcumin, and apigenin) on the gene expression of human dental pulp stem cells and evaluated their healing effects on critical-size defects in rat calvaria. The results showed that these compounds had positive effects on gene expression and apigenin exhibited the most significant bone healing effects. This study provides new possibilities for promoting bone regeneration through nutraceutical supplementation.
Article
Biology
Valeria Taliani, Giulia Buonaiuto, Fabio Desideri, Adriano Setti, Tiziana Santini, Silvia Galfre, Leonardo Schirone, Davide Mariani, Giacomo Frati, Valentina Valenti, Sebastiano Sciarretta, Emerald Perlas, Carmine Nicoletti, Antonio Musaro, Monica Ballarino
Summary: Long noncoding RNAs (lncRNAs) play a critical role in heart physiology and disease. We identified a lncRNA called pCharme that is associated with chromatin and is involved in myogenesis and cardiac muscle remodeling in mice. Through various molecular analyses, we found that pCharme is specifically expressed in cardiomyocytes and is important for their maturation and cardiac development. The loss of pCharme leads to delayed cardiomyocyte maturation and morphological alterations in the ventricular myocardium. This study provides valuable insights into a novel lncRNA-mediated regulatory mechanism in heart development and has implications for future theranostic applications targeting the Charme locus.
Article
Medicine, General & Internal
Francesco Coscia, Rosa Mancinelli, Paola Virginia Gigliotti, Franco Checcaglini, Giorgio Fano-Illic
Summary: This observational study examines the effects of physical activity on fatigue perception, maximum power output, sleep, and cognitive changes in long COVID-19 subjects. The results show that active subjects have significantly reduced fatigue perception compared to sedentary ones. Additionally, both active and sedentary subjects experienced reduced strength development, poor sleep quality, and mild cognitive impairment.
Article
Microbiology
Raffaella Franciotti, Pamela Pignatelli, Domenica Lucia D'Antonio, Rosa Mancinelli, Stefania Fulle, Matteo Alessandro De Rosa, Valentina Puca, Adriano Piattelli, Astrid Maria Thomas, Marco Onofrj, Stefano Luca Sensi, Maria Cristina Curia
Summary: Previous studies have shown that there is a connection between oral microbial dysbiosis and the development and progression of pathologies in the central nervous system. This study found that Porphyromonas gingivalis (Pg), a key pathogen in the oral cavity, had higher abundance in the oral cavities of patients with neurodegenerative diseases compared to healthy controls and patients with acute neurological conditions. The abundance of Pg in the oral cavity was also higher in patients with chronic neurological conditions compared to healthy controls. Only the patients with chronic neurological conditions had higher levels of anti-Pg antibodies in their serum. The immune system's response to Pg abundance in the oral cavity decreased progressively from patients with acute conditions to patients with chronic nervous system disorders and finally to patients with neurodegenerative diseases.
Proceedings Paper
Engineering, Biomedical
Flavia Forconi, Ludovica Apa, Marianna Cosentino, Antonio Musaro, Emanuele Rizzuto, Zaccaria Del Prete
Summary: This article introduces an innovative device for measuring the contractility of engineered skeletal muscle and evaluates the impact of moving the region of interest (ROI) on the measurement of contractile force. The experimental results demonstrate that the introduced errors by moving the ROI are always lower than 4%, and the influence of errors on the measurement is less significant for larger displacements.
2022 IEEE INTERNATIONAL SYMPOSIUM ON MEDICAL MEASUREMENTS AND APPLICATIONS (MEMEA 2022)
(2022)
Article
Chemistry, Multidisciplinary
Ester Sara Di Filippo, Sara Chiappalupi, Michele Balsamo, Marco Vukich, Guglielmo Sorci, Stefania Fulle
Summary: The study aims to investigate the effects of real microgravity on the differentiation capacity of human muscle precursor cells. The results will be helpful in preventing or counteracting muscle atrophy. Prolonged exposure to microgravity can lead to instability in organs and tissues, including excessive muscle atrophy, and affect the functionality of satellite cells.
APPLIED SCIENCES-BASEL
(2022)