Review
Nutrition & Dietetics
Agnieszka Zawada, Alicja Machowiak, Anna Maria Rychter, Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Agnieszka Dobrowolska, Iwona Krela-Kazmierczak
Summary: The formation of advanced glycation end-products (AGE) in tissues is a physiological process, but excessive production and storage can lead to inflammation. A sedentary lifestyle, hypercaloric and high-fructose diet, and increased intake of processed food contribute to the excessive production of AGE. Accumulation of AGE increases oxidative stress and initiates various diseases.
Article
Psychiatry
Gianluca Pandolfo, Giovanni Genovese, Antonio Bruno, Domenica Campolo, Valeria Tigano, Mariateresa Cristani, Marco Casciaro, Giovanni Pioggia, Sebastiano Gangemi
Summary: The pathophysiology of schizophrenia is still not well understood. Genetic factors and oxidative stress play key roles in its development and progression. Oxidative stress leads to the continuous production of oxidation products, such as AGEs and AOPPs, which interact with their receptors, amplifying the production of reactive oxygen species (ROS) and pro-inflammatory cytokines. In this study, plasma levels of AGEs and AOPPs were found to be significantly higher in schizophrenia patients compared to controls, confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could reduce oxidative stress and alleviate schizophrenia symptoms.
PSYCHIATRY RESEARCH
(2022)
Article
Andrology
Naoki Fujita, Mizuri Ishida, Takuro Iwane, Hiroyuki Suganuma, Mai Matsumoto, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Tatsuya Mikami, Ken Itoh, Chikara Ohyama
Summary: This study found a significant association between skin AGEs levels, blood antioxidative vitamin and carotenoid concentrations, and severe ED. Serum zeaxanthin levels were negatively correlated with skin AGEs levels, suggesting the potential effects of zeaxanthin on ED by reducing tissue AGEs levels.
WORLD JOURNAL OF MENS HEALTH
(2023)
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Article
Biotechnology & Applied Microbiology
Liuyang Ren, Ying Lou, Mingyu Sun
Summary: Evodiamine (EVO) is a novel anti-tumor drug that inhibits cell proliferation and invasion in oral squamous cell carcinoma (OSCC). EVO targets the downstream signaling pathways of AGE/RAGE by affecting RAGE, leading to inhibition of proliferation, invasion, and angiogenesis in OSCC cells.
Article
Biochemistry & Molecular Biology
Utkarsh Reddy Addi, Sneha Jakhotia, S. Sreenivasa Reddy, G. Bhanuprakash Reddy
Summary: Aging is a major risk factor for diseases, including neurodegenerative disorders. This study found that the accumulation of AGEs in the brain increases with age, which may lead to neuronal damage by affecting ER homeostasis, UPS, autophagic flux, and neuronal growth factors.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Biotechnology & Applied Microbiology
Lucas C. Olson, James T. Redden, Zvi Schwartz, David J. Cohen, Michael J. McClure
Summary: Advanced age causes harmful changes in skeletal muscles, leading to conditions such as muscle atrophy and an increase in collagen content, ultimately resulting in age-related muscle wasting disease. Advanced glycation end-products accumulate on muscular collagens in old age, promoting collagen accumulation and stiffening the microenvironment. Future research should focus on the role of AGEs in skeletal muscle aging.
BIOENGINEERING-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Lucas C. Olson, Tri M. Nguyen, Rebecca L. Heise, Barbara D. Boyan, Zvi Schwartz, Michael J. McClure
Summary: Decellularized tissues derived from aged sources exhibit age-dependent increases in collagen amount, cross-linking, and stiffness. This suggests that age is an important factor to consider when sourcing skeletal muscle extracellular matrix as a biomaterial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Rosa M. M. Smoor, Eric P. A. van Dongen, Lisa Verwijmeren, Marielle H. Emmelot-Vonk, Lisette M. M. Vernooij, Olaf L. L. Cremer, Peter G. G. Noordzij
Summary: In older cardiac surgery patients, higher levels of skin auto fluorescence (SAF) are associated with frailty and an increased risk of adverse outcomes. SAF level is most strongly associated with dependent living status and impaired cognition, and can potentially optimize preoperative risk stratification for cardiac surgery.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Review
Endocrinology & Metabolism
Bowen Wang, Deepak Vashishth
Summary: Hyperglycemia and oxidative stress in diabetes and aging lead to excessive accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone. AGEs/AGOEs disrupt bone turnover and deteriorate bone quality through alterations of organic matrix, mineral, and water content. This review explains the accumulation and impact of AGEs/AGOEs in bone, as well as their targeting in preclinical and clinical investigations for the management of diabetic, osteoporotic, and insufficiency fractures.
Review
Nutrition & Dietetics
Busra Demirer, Gulhan Samur
Summary: Excessive accumulation of AGEs in the body is associated with adverse health conditions. Maternal consumption of AGE-rich diet during pregnancy can increase body's AGE pool and lead to oxidative stress and inflammation. Maternal AGE levels are related to maternal and fetal complications during pregnancy.
Article
Cardiac & Cardiovascular Systems
Alain K. Koyama, Meda E. Pavkov, Yanjue Wu, Karen R. Siegel
Summary: This study aimed to investigate the association between dietary advanced glycation end products (AGEs) intake and mortality. The analysis of 5,474 adults with diabetes showed that higher AGEs intake was associated with lower concordance to dietary guidelines. However, there was no significant association between AGEs intake and all-cause mortality.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Kuo-Cheng Lan, Pei-Jin Peng, Ting-Yu Chang, Shing-Hwa Liu
Summary: This study aimed to explore the role of AGEs in renal function decline in the elderly and the protective effect of resveratrol, and to compare it with aminoguanidine as an AGEs inhibitor. The results showed that the administration of D-galactose significantly increased serum levels of AGEs and renal function markers, which could be reversed by treatment with aminoguanidine or resveratrol. These findings suggest that resveratrol could alleviate AGEs-related renal dysfunction through the improvement of renal cellular senescence, apoptosis, and fibrosis.
Article
Food Science & Technology
Huiyu Hu, Yuting Wang, Yousheng Huang, Yanpeng Yu, Mingyue Shen, Chang Li, Shaoping Nie, Mingyong Xie
Summary: This study investigated the effects of two dietary antioxidants (catechins and curcumin) and two dietary hydrocolloids (pectin and chitosan) on the formation of harmful heat-induced products in butter cookies. The results showed that catechins had the strongest inhibitory effects, but impaired the color and taste of the cookies. On the other hand, chitosan was not as effective but improved the sensory qualities of the butter cookies.
Review
Gastroenterology & Hepatology
Armando Rojas, Cristian Lindner, Ivan Schneider, Ileana Gonzalez, Miguel Angel Morales
Summary: Clinical and experimental research provide compelling evidence of the crucial contribution of chronic inflammation to the development of neoplasms, including gallbladder cancer. The RAGE/AGEs axis plays a key role in the initiation of an inflammatory environment, promoting tumor growth. Dietary intake of AGEs is associated with an increased risk of gallbladder cancer.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
