Article
Multidisciplinary Sciences
Ghada Omer Hamad Abd El-Raheem, Mudawi Mohammed Ahmed Abdallah, Mounkaila Noma
Summary: Hyperglycaemia is a significant risk factor in critically ill patients, but its management in ICU settings needs improvement. There is a need for enhanced training on hyperglycaemia control for healthcare staff in ICUs and the development of a local protocol for glycaemic control.
Review
Medicine, General & Internal
Johannes Roth, Oliver Sommerfeld, Andreas L. Birkenfeld, Christoph Sponholz, Ulrich A. Mueller, Christian von Loeffelholz
Summary: In the perioperative period, 30-80% of patients in intensive care develop hyperglycemia, with diabetic patients not benefiting as much from blood sugar reduction as metabolically healthy individuals. Therefore, blood sugar control in perioperative patients should focus on avoiding hypoglycemia while keeping blood glucose concentration under 10 mmol/L.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2021)
Article
Oncology
Emilie S. Zoltick, Stephanie A. Smith-Warner, Chen Yuan, Molin Wang, Charles S. Fuchs, Jeffrey A. Meyerhardt, Andrew T. Chan, Kimmie Ng, Shuji Ogino, Meir J. Stampfer, Edward L. Giovannucci, Kana Wu
Summary: The study suggests that higher post-diagnosis intake of sugar-sweetened beverages and sugars may be associated with higher colorectal cancer-specific mortality, but only up to 5 years from diagnosis, when more deaths were due to CRC. The inverse association between artificially sweetened beverages and CRC-specific mortality warrants further examination.
BRITISH JOURNAL OF CANCER
(2021)
Article
Nutrition & Dietetics
Jennifer L. Knopp, J. Geoffrey Chase, Geoffrey M. Shaw
Summary: This study investigated the impact of nutritional management on blood glucose outcomes in intensive care, finding that coordination of nutrition and insulin therapy is crucial for effective glycemic control. Results suggest that adjusting nutrition alongside insulin can improve glycemic control, particularly in patients with persistent hyperglycemia or low glucose tolerance.
CLINICAL NUTRITION
(2021)
Article
Engineering, Biomedical
Bo Zhi Chen, Wen Xuan Li, Yun Hao Feng, Xiao Peng Zhang, Jie Jiao, Zhuo Lin Li, Vahideh Nosrati-Siahmazgi, Mohammad-Ali Shahbazi, Xin Dong Guo
Summary: This study examined the combination of insulin-loaded dissolving microneedles (MNs) with insulin aspart (IAsp) or insulin degludec (IDeg) therapy for diabetes treatment. The results showed that the insulin-loaded MNs provided comparable blood glucose control abilities to subcutaneous injections in diabetic rats. The MNs have the potential to improve glycemic control and patient compliance, while reducing injection pain.
ACTA BIOMATERIALIA
(2023)
Article
Nutrition & Dietetics
Igor Eckert, Magali C. C. Kumbier, Flavia M. Silva, Oellen S. Franzosi, Jussara C. de Almeida
Summary: The study found that glycemic-control formulae were associated with better blood sugar control and lower insulin requirements in critically ill patients, but the results for clinical outcomes were not statistically significant. There was insufficient evidence to confirm important differences due to low quality of evidence.
CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Keyu Guo, Jianan Ye, Liyin Zhang, Qi Tian, Li Fan, Zhiyi Ding, Qin Zhou, Xia Li, Zhiguang Zhou, Lin Yang
Summary: The study found that glycemic control of type 1 diabetes mellitus deteriorated during the Chinese New Year public holiday in China, with mean blood glucose increasing, time above range extending, and time in range reducing. Interestingly, no significant changes were observed in the glucose control metrics in the CSII group, indicating the need for more refined management algorithms during this holiday period for T1DM patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Felix Klawitter, Johannes Ehler, Rika Bajorat, Robert Patejdl
Summary: Mitochondria play a crucial role in providing energy and participating in metabolism and signaling processes. However, mitochondrial dysfunction in critical illness can lead to organ failure and muscle wasting. This review aims to discuss the molecular mechanisms underlying mitochondrial dysfunction in intensive care unit-acquired weakness and critical illness myopathy, and its implications for muscle function and potential therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Jung Eun Yoo, Dahye Kim, Kyungdo Han, Sang Youl Rhee, Dong Wook Shin, Hyun Lee
Summary: The study found that there is an association between diabetes status and the development of tuberculosis. Individuals with diabetes have a higher risk of developing tuberculosis compared to those without diabetes, and the risk of tuberculosis increases with longer duration of diabetes.
Article
Medicine, Research & Experimental
Jan Gunst, Liese Mebis, Pieter J. Wouters, Greet Hermans, Jasperina Dubois, Alexander Wilmer, Eric Hoste, Dominique Benoit, Greet Van den Berghe
Summary: This study aims to investigate the optimal glucose control strategy in adult critically ill patients not receiving early parenteral nutrition. The multicenter randomized controlled trial will assess ICU dependency and hospital mortality as primary and safety endpoints, respectively.
Article
Endocrinology & Metabolism
Juliana M. Bue-Valleskey, Christof M. Kazda, Chenchen Ma, Jenny Chien, Qianyi Zhang, Emmanuel Chigutsa, William Landschulz, Axel Haupt, Juan P. Frias
Summary: This study evaluated the safety and efficacy of a fusion protein called BIF compared to degludec in insulin-naive patients with type 2 diabetes. The results showed that BIF achieved similar glycemic control as degludec and had a similar risk of hypoglycemia.
Article
Oncology
Masoud Amini Kahrizsangi, Zohreh Ebrahimi, Zainab Shateri, Fatemeh Mansouri, Ali Zangene, Milad Rajabzadeh-Dehkordi, Mehran Nouri, Bahram Rashidkhani
Summary: This study found that there is a positive correlation between high glycemic load, high insulin load, and high glycemic index with the odds of developing colorectal cancer. On the other hand, high carbohydrate quality index and low-carbohydrate diet score are significantly negatively associated with the odds of colorectal cancer. Therefore, it is recommended to follow a diet with high-quality carbohydrates, low glycemic index, and low glycemic load to minimize the risk of developing colorectal cancer.
Article
Multidisciplinary Sciences
Samaneh Hosseinzadeh, Zahra Khatirnamani, Enayatollah Bakhshi, Alireza Heidari, Arash Naghipour
Summary: The multivariate marginal model is used to examine the factors affecting FBS and HbA1c using longitudinal data. This study investigates these factors for patients with type 2 diabetes in Northern Iran. Using the 'mmm2' package in R-3.4.0, the data is analyzed and the coefficients for the interactions of different variables are determined. The similarity of coefficients is examined to improve the efficiency and reliability of the model.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Marcus Lind, Arndis F. Olafsdottir, Irl B. Hirsch, Jan Bolinder, Sofia Dahlqvist, Aldina Pivodic, Jarl Hellman, Magnus Wijkman, Erik Schwarcz, Henrik Albrektsson, Tim Heise, William Polonsky
Summary: The SILVER study demonstrates the long-term benefits of CGM on HbA(1c), hypoglycemia, treatment satisfaction, well-being, and hypoglycemic confidence in people with T1D managed with MDI.
Article
Endocrinology & Metabolism
Etienne Myette-Cote, Josephine Molveau, Zekai Wu, Marie Raffray, Marie Devaux, Semah Tagougui, Remi Rabasa-Lhoret
Summary: This study aimed to assess the safety and efficacy of combining meal bolus reduction and increased glucose target in the automated insulin delivery (AID) system for exercise sessions performed 60- and 120-min postmeal. The results showed that this method was effective and safe during moderate-intensity aerobic exercise, regardless of whether the exercise was performed 60 or 120 min after a meal.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)