期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 21, 期 -, 页码 161-169出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2014.07.023
关键词
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资金
- NanoNextNL (The Netherlands) [project 03C.3]
Following the successful application of in vivo chemistry in chemical biology there has been growing interest in extending the application scope to non-invasive molecular imaging and therapy in living animals and eventually humans. A typical example of such an application is pretargeted radioimmuno-imaging and -therapy: the tumor targeting of a tagged antibody followed by administration and binding of a small radiolabeled probe to the tag of the tumor-bound antibody. In this review, we describe the requirements to take the step to non-invasive applications in animals, summarize recent achievements in this field, and we offer a perspective on future developments.
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