期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 17, 期 3, 页码 406-411出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2013.03.022
关键词
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Antibody-drug conjugates (ADCs) require multiple assays for analytical and bioanalytical characterization due to their heterogeneous and dynamic nature. These assays can help address questions from the drug-loading distribution following conjugation to exposure-response relationships after dosing in vivo. This review describes new assay technologies that have been developed for physiochemical characterization and determination of pharmacokinetic parameters of ADCs.
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