期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 16, 期 1-2, 页码 45-53出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2012.03.004
关键词
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资金
- National Institutes of Health [AI058131, AI076389]
- University of Alabama at Birmingham (UAB) Center for AIDS Research
- UAB Center for Free Radical Biology
All pathogenic and nonpathogenic microbes are continuously exposed to environmental or endogenous reactive oxygen and nitrogen species, which can critically effect survival and disease. Iron-sulfur [Fe-S] cluster containing prosthetic groups provide the microbial cell with a unique capacity to sense and transcriptionally respond to diatomic gases (e.g. NO and O-2) and redox-cycling agents. Recent advances in our understanding of the mechanisms for how the FNR and SoxR [Fe-S] cluster proteins respond to NO and O-2 have provided new insights into the biochemical mechanism of action of the Mycobacterium tuberculosis (Mtb) family of WhiB [Fe-S] cluster proteins. These insights have provided the basis for establishing a unifying paradigm for the Mtb WhiB family of proteins. Mtb is the etiological agent for tuberculosis (TB), a disease that affects nearly one-third of the world's population.
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