期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 13, 期 4, 页码 451-459出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2009.07.018
关键词
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资金
- NIAID NIH HHS [AI 33696, R01 AI033696-16A1, R01 AI033696] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI033696] Funding Source: NIH RePORTER
In the past decade, the genes encoding all four enzymes responsible for the biosynthesis of mycothiol in Mycobacterium tuberculosis have been identified. Orthologs of each of these have been stably expressed and structurally characterized. The chemical mechanisms of all the four have also been studied. Because of the unique phylogenetic distribution of mycothiol, and the enzymes responsible for its biosynthesis, these enzymes represent interesting potential targets for antimycobacterial agents.
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