Article
Chemistry, Physical
Lin Sun, Miguel A. L. Marques, Silvana Botti
Summary: This work investigates the formation of sp2-bonded domains at different low-energy diamond grain boundaries and identifies the low-energy interface reconstructions using a constrained global-structure prediction algorithm. The simulations show that graphitic networks arise from the flattening and reconstruction of corrugated hexagonal layers with (111) orientation, and the most stable sp2 insertions occur between parallel diamond surfaces. The study also reveals the destabilizing effects of bond distortion and bending of graphitic planes at tilt grain boundaries. The electronic properties of these structures are also studied.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Automation & Control Systems
Carlos Alfaro Aragon, Ramon Guzman, Luis Garcia de Vicuna, Jaume Miret, Miguel Castilla
Summary: This article proposes a large-signal model and control method for microgrids. The model does not require direct voltage control and is able to maintain stability under different impedances and loads. Experimental results demonstrate satisfactory performance of the proposed control method in case of load variations and non-linear loads.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2022)
Article
Transportation
Can Chen, W. Bartley Hildreth, Keith Jacobi
Summary: This study analyzes and compares three recent state airport takeover attempts, describing the processes, identifying key motivating factors and arguments against state airport takeovers, and presenting the main issues of transitioning to a new governance structure. The study concludes with policy implications for future airport governance reforms.
JOURNAL OF AIR TRANSPORT MANAGEMENT
(2023)
Editorial Material
Biochemical Research Methods
Yafei Mao, Guojie Zhang
Summary: The release of the first telomere-to-telomere human genome sequence is a significant milestone in human genomics research, offering potential insights for evolutionary genomics. This article describes the advances of this new genome assembly and discusses the challenges of applying this sequencing strategy to various extant species.
Article
Materials Science, Multidisciplinary
Shujuan Wang, Khanh Dang, Rodney J. McCabe, Laurent Capolungo, Carlos N. Tome
Summary: A comprehensive study explored the facets that bound the compression twin in Ti, observing six new facets and validating the results through HRTEM observations and atomistic simulations. The new facets align with low-index interfaces, with those having lower surface energies forming extended interfaces, while higher surface energy facets are located at the twin tip region. These findings provide a better understanding of the 3D structure of compression twins in Ti and validate the MD procedure and Ti interatomic potential used in the study.
Article
Cell Biology
Futang Wan, Yongbo Ding, Yuebin Zhang, Zhenfang Wu, Shaobai Li, Lin Yang, Xiangyu Yan, Pengfei Lan, Guohui Li, Jian Wu, Ming Lei
Summary: The cryo-EM structure of human telomerase holoenzyme reveals the role of Leu980 residue in TERT in limiting the length of the primer-template duplex, and suggests a preformed active site for catalysis with hTR. The study also unveils a double-fingers architecture in TERT for ensuring nucleotide addition processivity, and proposes the zipper head Leu980 as a structural determinant for DNA synthesis pausing signal. Functional analyses demonstrate the essential role of the non-glycine zipper head in telomerase repeat addition processivity and telomere length homeostasis, as well as the conservation of this mechanism in all eukaryotic telomerases.
Article
Biochemistry & Molecular Biology
Xu Li, Meijie Wang, Wei Zheng, Wei Huang, Zeyu Wang, Kairang Jin, Lin Liu, Zhongbo Yu
Summary: Chromosome stability is primarily determined by telomere length, which is regulated by the core subunit TRF1 of shelterin. Research on the dynamics of TRF1 has shown its role in telomere organization, compaction, and interaction at telomeric DNA forks. Understanding these mechanisms can facilitate future studies on telomeres and the development of shelterin-targeted drugs.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Automation & Control Systems
Cong Zhang, Jie Wang, Qingchen Liu, Weiming Fu, Wei Xing Zheng
Summary: This paper focuses on optimal power control for sensors and attackers in a remote state estimation process to ensure the achievement of the estimation task under a denial-of-service (DoS) attack. It addresses the fading channel network and proposes a Nash Q-learning algorithm to find optimal power control strategies. The Bayesian game is employed to model the case with partial information, and type-contingent energy strategies are obtained based on the players' beliefs of the opponent's channel distribution.
JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS
(2023)
Article
Computer Science, Artificial Intelligence
Zhenwu Fang, Jinxiang Wang, Zejiang Wang, Jinhao Liang, Yahui Liu, Guodong Yin
Summary: This paper proposes a human-machine shared control framework considering driver's time-varying characteristics to improve the co-driving cooperation performance. By introducing driving intention and driving ability index, and designing a novel human-machine authority allocation strategy, the driver-vehicle interaction system is constructed. A T-S fuzzy robust state-feedback shared control system is developed to consider time-varying driver behaviors and vehicle states. The results show that the proposed control method has obvious superiority in improving performance of driving comfort, path tracking, and vehicle stability for the co-driving vehicles.
IEEE TRANSACTIONS ON INTELLIGENT VEHICLES
(2023)
Article
Engineering, Electrical & Electronic
Hanbin Zhou, Jian Yang, Liansheng Huang, Dongran Song, Mi Dong, Xiaojiao Chen
Summary: This study proposes a novel finite-state machine-based model predictive control method for three-level three-phase inverters. The state transition diagram of the finite-state machine is used as the operation guideline to avoid excessive voltage jumps. The algorithm selects no more than five voltage vectors as candidate vectors, based on the reference and previous optimal vector. By simplifying the cost function in terms of time duration, the computation cost for evaluating a candidate vector is significantly reduced. The proposed FSM-MPC algorithm achieves a 50% decrease in execution time compared to the MPC algorithm, while maintaining control performance.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2023)
Article
Physics, Multidisciplinary
J. Cerrillo, S. Oviedo Casado, J. Prior
Summary: Conventional control strategies based on a two-level model for nitrogen-vacancy centers fail in weak bias magnetic fields or strong microwave pulses. A novel control sequence that addresses a hidden Raman configuration with microwave pulses tuned to the zero-field transition shows excellent performance in typical dynamical decoupling sequences. This opens up possibilities for nano-NMR operation in low field environments.
PHYSICAL REVIEW LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Pavel Cuevas Diaz, Humberto Nicolini, German Alberto Nolasco-Rosales, Isela Juarez Rojop, Carlos Alfonso Tovilla-Zarate, Ester Rodriguez Sanchez, Alma Delia Genis-Mendoza
Summary: This study aimed to investigate the role of telomere length in three different types of diabetes: latent autoimmune diabetes of adulthood (LADA), latent autoimmune diabetes in the young (LADY), and type 2 diabetes mellitus (T2DM). A total of 115 patients were included, and their telomere length was measured using real-time Polymerase Chain Reaction. The results showed that T2DM patients had higher BMI compared to LADA and LADY groups, while LADA patients had shorter telomeres compared to T2DM patients but not LADY patients. Furthermore, T2DM may have longer telomeres thanks to the protective effects of both metformin and insulin, despite the higher BMI in this group.
Editorial Material
Multidisciplinary Sciences
Ali H. Brivanlou, Nicolas Rivron, Norbert Gleicher
Summary: In the next few years, continued exploration of human embryology is expected to bring significant advances in regenerative and reproductive medicine. As technologies progress, it is important to not only focus on their potential clinical applications, but also to consider the ethical implications involved.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Marine
Huapeng Zhang, Daqi Zhu, Chenxia Liu, Zhen Hu
Summary: In this paper, a cascaded dynamic tracking controller is proposed for the human occupied vehicle (HOV) system to solve the driving saturation and tracking disturbance problems caused by thruster failure, and the effectiveness of this control method is verified through simulation results.
Article
Automation & Control Systems
Tianyi Zeng, Abdelkhalick Mohammad, Andres Gameros Madrigal, Dragos Axinte, Max Keedwell
Summary: In this study, a human-robotic collaborative control system is developed for accurate path tracking subject to unknown external disturbances and multiple physical constraints. The system includes features such as a sliding-mode disturbance rejection term, tightened constraints, and real-time human modification of performance.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2023)
Article
Cell Biology
Mingqi Han, Christine E. Napier, Sonja Frolich, Erdahl Teber, Ted Wong, Jane R. Noble, Eugene H. Y. Choi, Roger D. Everett, Anthony J. Cesare, Roger R. Reddel
JOURNAL OF CELL SCIENCE
(2019)
Article
Multidisciplinary Sciences
Jieqiong Lou, Lorenzo Scipioni, Belinda K. Wright, Tara K. Bartolec, Jessie Zhang, V. Pragathi Masamsetti, Katharina Gaus, Enrico Gratton, Anthony J. Cesare, Elizabeth Hinde
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Review
Biochemistry & Molecular Biology
Noa Lamm, Samuel Rogers, Anthony J. Cesare
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Grzegorz Sarek, Panagiotis Kotsantis, Phil Ruis, David Van Ly, Pol Margalef, Valerie Borel, Xiao-Feng Zheng, Helen R. Flynn, Ambrosius P. Snijders, Dipanjan Chowdhury, Anthony J. Cesare, Simon J. Boulton
Article
Multidisciplinary Sciences
V. Pragathi Masamsetti, Ronnie Ren Jie Low, Ka Sin Mak, Aisling O'Connor, Chris D. Riffkin, Noa Lamm, Laure Crabbe, Jan Karlseder, David C. S. Huang, Makoto T. Hayashi, Anthony J. Cesare
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Omesha N. Perera, Alexander P. Sobinoff, Erdahl T. Teber, Ashley Harman, Michelle F. Maritz, Sile F. Yang, Hilda A. Pickett, Anthony J. Cesare, Jonathan W. Arthur, Karen L. MacKenzie, Tracy M. Bryan
Article
Oncology
Sunali Mehta, Cushla McKinney, Michael Algie, Chandra S. Verma, Srinivasaraghavan Kannan, Rhodri Harfoot, Tara K. Bartolec, Puja Bhatia, Alistair J. Fisher, Maree L. Gould, Kim Parker, Anthony J. Cesare, Heather E. Cunliffe, Scott B. Cohen, Torsten Kleffmann, Antony W. Braithwaite, Adele G. Woolley
Review
Cell Biology
Georgia R. Kafer, Anthony J. Cesare
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Genetics & Heredity
L'ubomir Tomaska, Anthony J. Cesare, Taghreed M. AlTurki, Jack D. Griffith
Article
Oncology
Sunali Mehta, Michael Algie, Tariq Al-Jabry, Cushla McKinney, Srinivasaraghavan Kannan, Chandra S. Verma, Weini Ma, Jessie Zhang, Tara K. Bartolec, V. Pragathi Masamsetti, Kim Parker, Luke Henderson, Maree L. Gould, Puja Bhatia, Rhodri Harfoot, Megan Chircop, Torsten Kleffmann, Scott B. Cohen, Adele G. Woolley, Anthony J. Cesare, Antony Braithwaite
Article
Multidisciplinary Sciences
Phil Ruis, David Van Ly, Valerie Borel, Georgia R. Kafer, Afshan McCarthy, Steven Howell, Robert Blassberg, Ambrosius P. Snijders, James Briscoe, Kathy K. Niakan, Paulina Marzec, Anthony J. Cesare, Simon J. Boulton
Summary: This study demonstrates that in mouse pluripotent embryonic stem cells and epiblast stem cells, TRF2 is largely dispensable for telomere protection, with cells exhibiting an attenuated telomeric DNA damage response and the ability to propagate for multiple generations even in the absence of TRF2. Cells exiting pluripotency rapidly switch to TRF2-dependent end protection, and embryos lacking Trf2 arrest before implantation with evidence of DNA damage response signaling and apoptosis in the non-pluripotent compartment. The formation of T-loops independently of TRF2 in ES cells explains why TRF2 is not essential for end protection during pluripotency.
Article
Cell Biology
Noa Lamm, Mark N. Read, Max Nobis, David Van Ly, Scott G. Page, V. Pragathi Masamsetti, Paul Timpson, Mate Biro, Anthony J. Cesare
NATURE CELL BIOLOGY
(2020)
Review
Cell Biology
Noa Lamm, Samuel Rogers, Anthony J. Cesare
Summary: This study focuses on the role of nuclear-specific filamentous actin in mobilizing damaged chromatin in response to DNA double-strand breaks and replication stress, as well as the importance of nuclear pore complexes and promyelocytic leukemia-nuclear bodies as specialized platforms for homology-directed repair. The literature suggests an emerging model where specific types of DNA lesions are subjected to nuclear-derived forces that promote interaction with repair hubs to facilitate specialized repair reactions.
TRENDS IN CELL BIOLOGY
(2021)
Article
Cell Biology
Alexandra M. Pinzaru, Mike Kareh, Noa Lamm, Eros Lazzerini-Denchi, Anthony J. Cesare, Agnel Sfeir
GENES & DEVELOPMENT
(2020)
Article
Gastroenterology & Hepatology
Samantha L. Ginn, Anais K. Amaya, Sophia H. Y. Liao, Erhua Zhu, Sharon C. Cunningham, Michael Lee, Claus Hallwirth, Grant J. Logan, Szun S. Tay, Anthony J. Cesare, Hilda A. Pickett, Markus Grompe, Kimberley Dilworth, Leszek Lisowski, Ian E. Alexander
