Article
Multidisciplinary Sciences
Tomoyuki Yoshida, Atsushi Yamagata, Ayako Imai, Juhyon Kim, Hironori Izumi, Shogo Nakashima, Tomoko Shiroshima, Asami Maeda, Shiho Iwasawa-Okamoto, Kenji Azechi, Fumina Osaka, Takashi Saitoh, Katsumi Maenaka, Takashi Shimada, Yuko Fukata, Masaki Fukata, Jumpei Matsumoto, Hisao Nishijo, Keizo Takao, Shinji Tanaka, Shigeo Okabe, Katsuhiko Tabuchi, Takeshi Uemura, Masayoshi Mishina, Hisashi Mori, Shuya Fukai
Summary: Mutations of Neuroligin 3 (NLGN3) have been linked to autism spectrum disorder (ASD). Researchers have identified a new interaction between NLGN3 and a splice variant of protein tyrosine phosphatase delta (PTP delta) and its impact on social behavior development in mice. The study suggests that both canonical and non-canonical NLGN3 pathways compete and regulate the development of sociality.
NATURE COMMUNICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Ye Chen, Jing Hua, Yueqing Li, Qi Zhang, He Shao, Wen Li, Haifeng Ling, Xiangxing Xu, Wei Huang, Mingdong Yi
Summary: A p-type synaptic OFET memory with CsPbBr3 quantum dots as nano-floating gates is developed to emulate the excitatory-inhibitory responses of biological synapses. By controlling the offset difference between stimulus voltage and reading voltage, the concurrent and independently expressed excitatory and inhibitory responses are successfully implemented. This reconfigurable modulation is achieved through the dynamic competition between external and built-in electric fields.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Neurosciences
David M. Steffen, Sarah L. Ferri, Charles G. Marcucci, Kelsey L. Blocklinger, Michael J. Molumby, Ted Abel, Joshua A. Weiner
Summary: Cell adhesion molecules play a key role in neural circuit formation, with gamma-protocadherins negatively regulating neuroligins to limit synapse density. Loss of gamma-Pcdhs results in increased inhibitory synapse density and abnormal behavior phenotypes.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Zheng Wen, Shuhan Wang, Fangzhou Yi, Dingting Zheng, Chengyuan Yan, Zhenhua Sun
Summary: Fully optical artificial synapses are essential for neuromorphic computing, and this research demonstrates the successful emulation of synaptic plasticity and memory transition by combining different trap matrices to achieve bidirectional photoresponse.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Julio Santos-Terra, Iohanna Deckmann, Giovanna Carello-Collar, Gustavo Della-Flora Nunes, Guilherme Bauer-Negrini, Gustavo Brum Schwingel, Mellanie Fontes-Dutra, Rudimar Riesgo, Carmem Gottfried
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by brain alterations and E/I imbalance. This study investigates the inhibitory components associated with ASD and suggests that prenatal treatment with resveratrol (RSV) may have preventive effects on ASD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Qian Wang, Zhenzhen Feng, Hua He, Xiang Hu, Jian Mao, Xiaoliang Chen, Lihua Liu, Xiaoyun Wei, Di Liu, Simin Bi, Xiaojuan Wang, Baosheng Ge, Daoyong Yu, Fang Huang
Summary: The study introduces a method to develop non-blinking and photoresistant fluorescent carbon dots by introducing multiple aromatic domains onto a single carbon dot, demonstrating their great potential for imaging and tracking receptors on a live cell membrane.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Noriko Koganezawa, Kenji Hanamura, Manuela Schwark, Dilja Krueger-Burg, Hiroshi Kawabe
Summary: The study used 3D-STED microscopy to analyze the morphology of synapses and found an increase in excitatory synapses in specific regions in a mouse model of autism spectrum disorder. This analysis method will open up new areas in developmental neuroscience in the future.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Kheibar Dashtian, Fatemeh Binabaji, Rouholah Zare-Dorabei
Summary: Wearable sweat sensors offer exciting opportunities for personal health monitoring and noninvasive biomarker measurements. This study presents a portable microfluidic device capable of simultaneous sweat sampling and fluorometric sensing of potential biomarkers for kidney disease monitoring. The device integrates seamlessly with smartphones for easy data retrieval and analysis. The sensors show exceptional performance, with low detection limits and remarkable selectivity. The evaluation extends to monitoring kidney diseases in real-world scenarios, showing the potential of low-cost, multidiagnostic microfluidic sensor arrays for enhanced disease detection and healthcare outcomes.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Shanu George, John Bear, Michael J. Taylor, Karthik Kanamalla, Christopher D. Fekete, Tzu-Ting Chiou, Celia P. Miralles, Theofilos Papadopoulos, Angel L. De Blas
Summary: Collybistin (CB) is a guanine nucleotide exchange factor selectively localized at GABAergic and glycinergic postsynapses. Different isoforms of collybistin are expressed in the brain, with CBSH3- protein playing a significant role in the regulation of the size of GABAergic postsynapse clusters, particularly in parvalbumin positive interneurons. The lack of CBSH3- expression is an important issue because it has a strong effect in promoting the postsynaptic clustering of gephyrin and GABA-A receptors.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Cell Biology
Sabrina Briguglio, Clara Cambria, Elena Albizzati, Elena Marcello, Giovanni Provenzano, Angelisa Frasca, Flavia Antonucci
Summary: Ataxia-Telangiectasia Mutated (ATM) is a protein kinase involved in DNA repair processes. Mutations in the Atm gene cause Ataxia-Telangiectasia (AT), a disorder characterized by ataxic movements, immune alterations, genomic instability, and cancer predisposition. Recent studies have shown unexpected roles of ATM in cognition and synaptic function, suggesting the importance of understanding ATM-dependent mechanisms in neurodevelopmental and degenerative disorders.
Article
Nanoscience & Nanotechnology
Joohee Jeon, Sun-heui Yoon, Min-Ah Oh, Wonkyung Cho, Ji Yong Kim, Chang Il Shin, Eun Joong Kim, Taek Dong Chung
Summary: The coordination of synapses onto electrodes with high specificity is crucial, and using neuroligin-1 protein on electrode surfaces can lead to the formation of synapses with type specificity and structural robustness. This approach may open up new possibilities in interfacing neural circuitry with electronics.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Multidisciplinary Sciences
Artem N. Abramov, Igor Y. Chestnov, Ekaterina S. Alimova, Tatiana Ivanova, Ivan S. Mukhin, Dmitry N. Krizhanovskii, Ivan A. Shelykh, Ivan V. Iorsh, Vasily Kravtsov
Summary: By using local deformation of monolayer WSe2, we have successfully created high-purity single-photon emitters. Through nanoindentation and atomic force microscopy, we have identified the single-photon emitting sites and reconstructed the details of the surrounding local strain potential. The experimental results suggest that the single-photon emission is likely due to strain-induced spectral shift of dark excitonic states and their hybridization with localized states of individual defects.
NATURE COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Ujjal Das, Pranab Kumar Sarkar, Dip Das, Bappi Paul, Asim Roy
Summary: The fabrication of perovskite-type rubidium lead chloride quantum dots is reported as a functional layer in a memristive system. The device exhibits reproducible bipolar switching behavior and demonstrates essential synaptic functions.
ADVANCED ELECTRONIC MATERIALS
(2022)
Article
Cell Biology
Shanu George, Tzu-Ting Chiou, Karthik Kanamalla, Angel L. De Blas
Summary: The subunit composition of GABA(A) receptors plays a key role in determining their synaptic or extrasynaptic localization. The Geph/CB lattice can trap both synaptic and extrasynaptic GABA(A) receptors, but does not play a decisive role in their synaptic localization. Neurons likely have mechanisms to prevent the trapping of certain extrasynaptic GABA(A) receptors by the postsynaptic Geph/CB lattice.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Zoology
Natalia M. Biserova, Alfia R. Mustafina, Olga Raikova
Summary: A novel complex neuro-glandular brain structure associated with sensory elements has been discovered in the plerocercoid parasite of Gadus morua from the White Sea. This structure, consisting of both nervous and glandular elements, is suggested as a model for the Diphyllobothriidae family. Significant differences in the architecture of the plerocercoid brain at the family level have been observed within the order Diphyllobothriidea. Serotonin, FMRFamide, and GABA-like immunoreactive neurons are present in various parts of the parasite.
Article
Biochemistry & Molecular Biology
Yingzhou Edward Pan, Debora Tibbe, Frederike Leonie Harms, Carsten Reissner, Kerstin Becker, Bri Dingmann, Ghayda Mirzaa, Anja A. Kattentidt-Mouravieva, Moneef Shoukier, Shagun Aggarwal, Markus Missler, Kerstin Kutsche, Hans-Juergen Kreienkamp
Summary: Mutations in the X-linked gene coding for CASK are associated with severe neurological disorders, and missense mutations can affect the interactions between CASK and other proteins, leading to altered patient phenotypes.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Stefanie Heiden, Rebecca Siwek, Marie-Luise Lotz, Sarah Borkowsky, Rita Schroeter, Pavel Nedvetsky, Astrid Rohlmann, Markus Missler, Michael P. Krahn
Summary: The study revealed that in Drosophila nephrocytes, the apical-basal polarity regulators play a crucial role in regulating the morphology and assembly/maintenance of slit diaphragms, with distinct functions in endocytosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Clemens L. Schoepf, Cornelia Ablinger, Stefanie M. Geisler, Ruslan Stanika, Marta Campiglio, Walter A. Kaufmann, Benedikt Nimmervoll, Bettina Schlick, Johannes Brockhaus, Markus Missler, Ryuichi Shigemoto, Gerald J. Obermair
Summary: The alpha(2)delta subunits in nerve cells play a critical role in the formation and organization of glutamatergic synapses, with defects leading to synaptic dysfunction and potentially neurological diseases. Each individual alpha(2)delta isoform can rescue presynaptic calcium channel trafficking and expression of synaptic proteins, suggesting a highly redundant role as synaptic organizers. These findings suggest a shift in understanding of excitatory synapse formation, highlighting the importance of presynaptic differentiation and the potential of alpha(2)delta subunits as nucleation points for synaptic organization.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Anatomy & Morphology
D. Darici, C. Reissner, J. Brockhaus, M. Missler
Summary: The implementation of an online histology course is technically feasible, effective, and well accepted among students. Student attendance is stable, learning outcomes are comparable, and the digital version is positively evaluated.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2021)
Article
Biochemistry & Molecular Biology
Nancy William, Carsten Reissner, Robert Sargent, Todd M. Darlington, Emily DiBlasi, Qingqin S. Li, Brooks Keeshin, William B. Callor, Elliott Ferris, Leslie Jerominski, Ken R. Smith, Erik D. Christensen, Douglas M. Gray, Nicola J. Camp, Markus Missler, Megan E. Williams, Hilary Coon
Summary: Variants in NRXN1 and related synaptic genes are associated with increased familial risk of suicide death, and these variants have an impact on binding interactions with partners. Further study on these variants is warranted as risk factors for suicide death.
MOLECULAR PSYCHIATRY
(2021)
Article
Anatomy & Morphology
Shima Ferdos, Johannes Brockhaus, Markus Missler, Astrid Rohlmann
Summary: Communication between neurons through synapses involves the release of synaptic vesicles and dense-core vesicles. This study found that beta-Nrxns are involved in the distribution of presynaptic DCVs, providing evidence from conditional and constitutive KO mouse models.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Education, Scientific Disciplines
Dogus Darici, Markus Missler, Anna Schober, Max Masthoff, Hans Schnittler, Martina Schmitz
Summary: The study highlights the importance of professional identity formation (PIF) in undergraduate sonoanatomy teaching. On-site sonoanatomy sessions were found to support students' transition from pre-clinical to clinical phase, increasing their interest in the medical profession. However, the shift to online-only format during the Covid-19 pandemic resulted in a decrease in PIF-related variables, increased stress levels, and reduced long-term academic performance.
ANATOMICAL SCIENCES EDUCATION
(2022)
Article
Biochemistry & Molecular Biology
Maximilian M. Gass, Sarah Borkowsky, Marie-Luise Lotz, Rebecca Siwek, Rita Schroeter, Pavel Nedvetsky, Stefan Luschnig, Astrid Rohlmann, Markus Missler, Michael P. Krahn
Summary: Drosophila nephrocytes, similar to mammalian podocytes, exhibit characteristics of epithelial cells. Research has shown that phospholipid PI(4,5)P2 plays a crucial role in slit diaphragm formation, while PI(3,4,5)P3 has minimal impact on nephrocyte function.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Education, Scientific Disciplines
Dogus Darici, Agnes Yueh-Dan Schneider, Markus Missler, Bettina Pfleiderer
Summary: This study investigated the presence of gender bias in anatomy e-learning platforms and found that they had a more balanced representation of gender compared to traditional textbooks. The results highlight the importance of electronic platforms in reducing stereotypical perceptions of human anatomy.
ANATOMICAL SCIENCES EDUCATION
(2023)
Article
Biochemistry & Molecular Biology
Cornelia Ablinger, Clarissa Eibl, Stefanie M. Geisler, Marta Campiglio, Gary J. Stephens, Markus Missler, Gerald J. Obermair
Summary: This study identifies alpha(2)delta-4 and Cachd1 as presynaptic regulators of synapse formation, differentiation, and calcium channel functions that can partially compensate for the loss of alpha(2)delta-1-3. Moreover, it shows that regulating glutamatergic synapse formation and differentiation is a critical and surprisingly redundant function of alpha(2)delta and Cachd1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Karen Perez de Arce, Adema Ribic, Dhrubajyoti Chowdhury, Katherine Watters, Garth J. J. Thompson, Basavaraju G. G. Sanganahalli, Elizabeth T. C. Lippard, Astrid Rohlmann, Stephen M. M. Strittmatter, Markus Missler, Fahmeed Hyder, Thomas Biederer
Summary: LRRTM1 is a post synaptic adhesion protein that promotes synaptic transmission. The authors found that LRRTM1 and SynCAM 1 work together to organize synapses in the prefrontal cortex, affecting cognitive function in mice. The study highlights the roles of LRRTM1 and SynCAM 1 in synaptic, network, and behavioral domains.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Tina Ghelani, Marc Escher, Ulrich Thomas, Klara Esch, Janine Luetzkendorf, Harald Depner, Marta Maglione, Pierre Parutto, Scott Gratz, Tanja Matkovic-Rachid, Stefanie Ryglewski, Alexander M. Walter, David Holcman, Kate O'Connor Giles, Martin Heine, Stephan J. Sigrist
Summary: In this study, dynamic intravital single-molecule imaging was used to investigate the interaction between scaffold proteins and voltage-gated calcium channels (VGCCs) during presynaptic homeostatic potentiation in Drosophila AZs. It was found that the interaction between the intracellular carboxyl terminus of the Cac channel and the amino-terminal region of the ELKS-family protein Bruchpilot played a crucial role in the sustained potentiation of AZs.
Review
Biochemistry & Molecular Biology
Jennifer Heck, Ana Carolina Palmeira Do Amaral, Stephan Weissbach, Abderazzaq El Khallouqi, Arthur Bikbaev, Martin Heine
Summary: Voltage-gated calcium channels (VGCCs) play a crucial role in regulating calcium influx in excitable cells, triggering signaling cascades and neurotransmitter release. Recent studies have expanded the understanding of VGCCs beyond being mere calcium-permeable channels, revealing their involvement in various cellular functions such as voltage sensing, complex formation with other proteins, and direct participation in gene regulation.
Article
Oncology
Thomas K. Albert, Marta Interlandi, Martin Sill, Monika Graf, Natalia Moreno, Kerstin Menck, Astrid Rohlmann, Viktoria Melcher, Sonja Korbanka, Gerd Meyer zu Hoerste, Tobias Lautwein, Michael C. Fruehwald, Christian F. Krebs, Doerthe Holdhof, Melanie Schoof, Annalen Bleckmann, Markus Missler, Martin Dugas, Ulrich Schueller, Natalie Jaeger, Stefan M. Pfister, Kornelius Kerl
Summary: This study highlights the significance of intercellular communication in medulloblastoma, particularly in the sonic hedgehog subgroup where tumor cells display a differentiation blockade. The presence of extracellular vesicles in the tumor niche and their transfer between cells have been identified as potential factors influencing gene expression profiles and tumor behavior.