Article
Clinical Neurology
Giulia Buzi, Chiara Fornari, Alessio Perinelli, Veronica Mazza
Summary: This meta-analysis revealed a decrease in alpha synchrony in the brain during the early stages of Mild Cognitive Impairment (MCI), particularly in the temporal-parietal and frontal-parietal regions. These findings suggest that synchrony measures have promise in detecting early pathological markers of connectivity alterations in Alzheimer's disease (AD).
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Psychiatry
Dawei Miao, Xiaoguang Zhou, Xiaoyuan Wu, Chengdong Chen, Le Tian
Summary: This study investigated the differences in functional connectivity density (FCD) between AD and MCI, and found significant differences in global FCD values between AD, MCI, and healthy controls. These findings provide new insights into the progressive brain changes from MCI to AD.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Engineering, Biomedical
Guosheng Yi, Yanbo Wang, Liufang Wang, Chunguang Chu, Jiang Wang, Xiao Shen, Xiaoxuan Han, Zhen Li, Lipeng Bai, Zhuo Li, Rui Zhang, Yanlin Wang, Xiaodong Zhu, Chen Liu
Summary: This study aims to explore the dynamic changes in functional connectivity networks induced by mild cognitive impairment (MCI) in early Parkinson's disease (PD) patients. The results show that there are abnormal increases in functional network stability and decreased dynamic connectivity fluctuations in specific brain regions in ePD-MCI patients, which may contribute to identifying and predicting cognitive impairment in early PD.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Neurosciences
Xiaocao Liu, Qingze Zeng, Xiao Luo, Kaicheng Li, Xiaopei Xu, Luwei Hong, Jixuan Li, Xiaojun Guan, Xiaojun Xu, Peiyu Huang, Min-Ming Zhang
Summary: This study investigated the effect of the APOE epsilon 2 allele on basal forebrain cholinergic system functional connectivity in cognitively normal and mild cognitive impairment patients. The results showed an interaction effect between APOE epsilon 2 genotype and functional connectivity, and the functional connectivity was associated with cognitive performance. Therefore, the APOE epsilon 2 genotype may have a protective role in mild cognitive impairment.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Mohammadmahdi Rahimiasl, Nasrollah Moghadam Charkari, Foad Ghaderi
Summary: This study introduces a novel method based on resting-state functional connectivity for accurate classification of individuals at different stages of dementia, achieving promising results with high accuracy rates.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Geriatrics & Gerontology
Jordan Williamson, Andriy Yabluchanskiy, Peter Mukli, Dee H. Wu, William Sonntag, Carrie Ciro, Yuan Yang
Summary: Research shows that females are more impacted by mild cognitive impairment (MCI) and experience greater cognitive deterioration than males in the same disease stage. These sex differences are linked to neuroimaging markers of brain pathology, such as hippocampal volumes. This study found that males have stronger connectivity between the hippocampus and the precuneus cortex and brain stem compared to females.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Maggie Roy, Manon Edde, Melanie Fortier, Etienne Croteau, Christian-Alexandre Castellano, Valerie St-Pierre, Camille Vandenberghe, Francois Rheault, Mahsa Dadar, Simon Duchesne, Christian Bocti, Tamas Fulop, Stephen C. Cunnane, Maxime Descoteaux
Summary: This study aimed to assess the impact of a 6-month ketogenic intervention on the functional connectivity within brain resting-state networks and its relationship to improved cognitive outcomes. The findings suggest that ketones can improve functional connectivity in the dorsal attention network and cognitive abilities in individuals with mild cognitive impairment.
NEUROBIOLOGY OF AGING
(2022)
Article
Psychiatry
Shanshan Chen, Huimin Wu, Yu Song, Honglin Ge, Zheng Yan, Chen Xue, Wenzhang Qi, Qianian Yuan, Xingjian Lin, Jiu Chen
Summary: This study found that progressive mild cognitive impairment (pMCI) is associated with an increased risk of Alzheimer's disease (AD). The differences in inter-hemispheric structural and functional alterations between pMCI and stable mild cognitive impairment (sMCI) are still unknown. The findings suggest that the destruction of homotopic connectivity and corpus callosum atrophy partially mediate the association between inter-hemispheric connectivity and cognitive impairment in pMCI.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Qi Feng, Luoyu Wang, Xue Tang, Hanjun Hu, Xiuhong Ge, Zhengluan Liao, Zhongxiang Ding
Summary: By studying the dynamic and static changes of brain networks using the triple network model, sFC and dFC may serve as potential biomarkers for AD and aMCI.
FRONTIERS IN NEUROLOGY
(2023)
Article
Anatomy & Morphology
Yuan Jiang, Pan Wang, Jiaping Wen, Jianlin Wang, Hongyi Li, Bharat B. Biswal
Summary: This study utilized functional connectivity analysis to investigate abnormal brain connections between white matter and gray matter in patients with MCI. The results showed that compared to healthy controls, MCI patients exhibited specific dysconnectivity in certain brain regions, particularly in the connections between the hippocampus and the temporal pole. These findings are important for understanding the mechanisms of memory decline in MCI and the progression of Alzheimer's disease.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Chi Ieong Lau, Jiann-Horng Yeh, Yuh-Feng Tsai, Chen-Yu Hsiao, Yu-Te Wu, Chi-Wen Jao
Summary: Mild cognitive impairment (MCI) is an intermediate stage to Alzheimer's disease, and cerebral morphological alterations in cortical subregions can accurately predict MCI. This study used the Desikan-Killiany cortical atlas to segment participants' cerebral cortex and applied fractal dimension (FD) to assess morphological changes. The MCI group showed decreased FD values in various brain regions compared to the control group. A novel FD-based brain structural network was proposed and demonstrated that the MCI group had fewer and smaller modules with decreased connectivity between lobes. The results suggest that this method can be a useful tool for early detection of MCI.
Review
Neurosciences
Hao Lei, Rong Hu, Guanghua Luo, Tingqian Yang, Hui Shen, Hao Deng, Chunyu Chen, Heng Zhao, Jincai Liu
Summary: Type 2 diabetes is associated with cognitive impairment, and changes in neuronal neuropathies and metabolism affect the structural and functional connections in the brain.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Feng Feng, Weijie Huang, Qingqing Meng, Weijun Hao, Hongxiang Yao, Bo Zhou, Yan'e Guo, Cui Zhao, Ningyu An, Luning Wang, Xusheng Huang, Xi Zhang, Ni Shu
Summary: The combination of hippocampal volume and structural connectivity (number of connecting fibers) is a new perspective for the discrimination of Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI). Despite decreases in volume and structural connectivity of the bilateral hippocampi in patients with AD and aMCI, only hippocampal volume correlated with neuropsychological test scores.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Alvaro Santos-Ortega, Carmen Alba-Linero, Facundo Urbinati, Carlos Rocha-de-Lossada, Rafael Orti, Jose Antonio Reyes-Bueno, Francisco Javier Garzon-Maldonado, Vicente Serrano, Carmen de Rojas-Leal, Carlos de la Cruz-Cosme, Manuela Espana-Contreras, Marina Rodriguez-Calvo-de-Mora, Natalia Garcia-Casares
Summary: This study analyzed retinal changes in patients with mild cognitive impairment (MCI) using optical coherence tomography angiography (OCT-A) and found that diabetes may exacerbate retinal vascular changes when combined with MCI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Cuibai Wei, Shuting Gong, Qi Zou, Wei Zhang, Xuechun Kang, Xinliang Lu, Yufei Chen, Yuting Yang, Wei Wang, Longfei Jia, Jihui Lyu, Baoci Shan
Summary: The study found that changes in the structural brain networks were more pronounced than the metabolic brain networks in patients with mild cognitive impairment (MCI), and certain brain regions were associated with MCI. The correlation between atrophy in key brain regions and cognitive function is important in understanding the pathological mechanisms of MCI.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Psychology, Developmental
Angel Nevado, David Del Rio, Javier Pacios, Fernando Maestu
Summary: Neuropsychological tests have been commonly used to study cognitive functions. However, network analysis has been less explored in this field. This study analyzed the network structure of neuropsychological test scores in different populations and found that executive function plays a central role in cognitive abilities across all groups.
AGING NEUROPSYCHOLOGY AND COGNITION
(2022)
Article
Neurosciences
Claudio Babiloni, Giuseppe Noce, Raffaele Ferri, Roberta Lizio, Susanna Lopez, Ivan Lorenzo, Federico Tucci, Andrea Soricelli, Montserrat Zurron, Fernando Diaz, Flavio Nobili, Dario Arnaldi, Francesco Fama, Carla Buttinelli, Franco Giubilei, Virginia Cipollini, Moira Marizzoni, Bahar Guntekin, Ebru Yildirim, Lutfu Hanoglu, Gorsev Yener, Duygu Hunerli Gunduz, Paolo Onorati, Fabrizio Stocchi, Laura Vacca, Fernando Maestu, Giovanni B. Frisoni, Claudio Del Percio
Summary: In elderly individuals and patients with ADMCI, the presence of sex differences significantly affects the magnitude of rsEEG source activities, with females showing higher alpha source activities. These sex effects are independent of core genetic, neuropathological, structural neurodegenerative, and cerebrovascular variables characterizing sporadic AD-related processes in ADMCI seniors.
Article
Clinical Neurology
Ricardo Bruna, David Lopez-Sanz, Fernando Maestu, Ann D. Cohen, Anto Bagic, Ted Huppert, Tae Kim, Rebecca E. Roush, Betz Snitz, James T. Becker
Summary: This study investigated the mechanisms behind Alzheimer's disease and found that patients with amnestic MCI showed a slowing of brain activity, which was not observed in individuals without subjective complaints. This raises interesting questions about this particular group of individuals and the underlying brain mechanisms behind their cognitive impairment.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Article
Neurosciences
Ricardo Bruna, Fernando Maestu, David Lopez-Sanz, Anto Bagic, Ann D. Cohen, Yue-Fang Chang, Yu Cheng, Jack Doman, Ted Huppert, Tae Kim, Rebecca E. Roush, Beth E. Snitz, James T. Becker
Summary: The study found that older females had higher phase locking values in networks affected during the asymptomatic phase of neurodegenerative disorders, similar to individuals with mild cognitive impairment. This suggests that women may experience brain functional changes earlier in life than men, potentially explaining the higher prevalence of dementia among women.
BRAIN CONNECTIVITY
(2022)
Article
Clinical Neurology
Sandra Pusil, Lucia Torres-Simon, Brenda Chino, Maria Eugenia Lopez, Leonides Canuet, Alvaro Bilbao, Fernando Maestu, Nuria Paul
Summary: Stroke is a major cause of death globally, resulting in cognitive and physical deficits. Neuropsychological rehabilitation plays a significant role in the recovery process, which is related to the enhancement of functional connectivity.
FRONTIERS IN NEUROLOGY
(2022)
Correction
Geriatrics & Gerontology
Ricardo Bajo, Nazareth P. Castellanos, Maria Eugenia Lopez, Jose Maria Ruiz-Sanchez de Leon, Pedro Montejo, Mercedes Montenegro, Marcos Llanero, Pedro Gil, Raquel Yubero, Evgenia Baykova, Nuria Paul, Sara Aurtenetxe, Francisco Del Pozo, Fernando Maestu
Article
Clinical Neurology
Brenda Chino-Vilca, Inmaculada Concepcion Rodriguez-Rojo, Lucia Torres-Simon, Pablo Cuesta, Anna Carnes Vendrell, Gerard Pinol-Ripoll, Raquel Huerto, Nuria Tahan, Fernando Maestu
Summary: The study aims to evaluate the correlations between electroencephalography (EEG) and cerebrospinal fluid (CSF) markers in mild cognitive impairment (MCI) population. The findings indicate a negative correlation between A β-42 load and central-posterior theta power, as well as a negative correlation between t-tau and widespread alpha power in males. In females, there is a significant negative correlation between t-tau and widespread beta power.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Geriatrics & Gerontology
Brenda Chino, Pablo Cuesta, Javier Pacios, Jaisalmer de Frutos-Lucas, Lucia Torres-Simon, Sandra Doval, Alberto Marcos, Ricardo Bruna, Fernando Maestu
Summary: Delayed recall (DR) impairment is a significant predictive factor for the progression to Alzheimer's disease (AD). Changes in brain functional connectivity (FC) accompany the decline in DR performance, and the relationship between the two phenomena has attracted interest. The APOE genotype may play a moderator role in this association. Higher FC in the beta band in the right occipital region is associated with lower DR scores, with an anteroposterior link observed in MCI. APOE genotype moderates the association between beta FC and DR performance in the CI group.
Article
Clinical Neurology
David Mata-Marin, Jose angel Pineda-Pardo, Mario Michiels, Cristina Pagge, Claudia Ammann, Raul Martinez-Fernandez, Jose Antonio Molina, Lydia Vela-Desojo, Fernando Alonso-Frech, Ignacio Obeso
Summary: This study provides evidence for the balance between enhanced desire towards reward and cognitive control deficits in patients with impulse-control disorder, specifically hypersexuality, in Parkinson's disease under dopamine replacement therapy. The study also identifies the underlying fronto-striatal and mesolimbic circuitry involved in uncontrollable sexual responses and demonstrates that cortical neuromodulation can alleviate this symptom.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Multidisciplinary Sciences
Patrique Fiedler, Jens Haueisen, Ana M. Cebolla Alvarez, Guy Cheron, Pablo Cuesta, Fernando Maestu, Michael Funke
Summary: The cognitive performance of the crew is crucial for the safety and success of space flights. Monitoring cognitive performance during space missions is important and can be done using compact mobile EEG devices. However, the signal quality of EEG may be affected by nearby electronic devices and movements. This study compares the noise characteristics of EEG recordings in space and on the ground, and finds that in-flight recordings have significantly lower noise levels. Actively shielded mobile dry EEG systems can be used for neuroscientific research and cognitive monitoring during long-duration space missions.
Article
Clinical Neurology
Pablo Cuesta, Ricardo Bruna, Ekta Shah, Christopher Laohathai, Stephanie Garcia-Tarodo, Michael Funke, Gretchen Von Allmen, Fernando Maestu
Summary: Cuesta et al. developed an in silico personalized protocol for epilepsy surgery planning using magnetoencephalography spike network analysis. The model showed high performance in a cohort of 24 paediatric patients with drug-resistant epilepsy. The study aims to improve surgical outcomes by testing surgical hypotheses in silico based on individual patient data.
BRAIN COMMUNICATIONS
(2023)
Proceedings Paper
Acoustics
Diana Andres, Alicia Carrion, Nathalie Lamothe, Jose A. Pineda-Pardo, Noe Jimenez, Francisco Camarena
Summary: The aim of this study is to design and utilize a large-aperture focused transducer with a holographic lens to selectively sonicate small deep-brain structures in non-human primates. Through experimental evaluation and numerical simulations, we demonstrate that this technology can precisely target the therapeutic area and generate the desired effects of cavitation.
2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS)
(2022)
Article
Clinical Neurology
Pablo Cuesta, Manuela Ochoa-Urrea, Michael Funke, Omar Hasan, Ping Zhu, Alberto Marcos, Maria Eugenia Lopez, Paul E. Schulz, Samden Lhatoo, Dimitrios Pantazis, John C. Mosher, Fernando Maestu
Summary: Cuesta et al. found that epileptiform activity in patients with mild cognitive impairment is associated with reduced functional connectivity in the gamma frequency band of the right temporal cortex. This reduced connectivity is related to grey matter atrophy in multiple cortical regions. The study provides evidence for neuronal hyperexcitability in Alzheimer's disease and highlights the potential impact on functional brain networks and cognitive decline.
BRAIN COMMUNICATIONS
(2022)