期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 22, 期 2, 页码 200-210出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2011.02.007
关键词
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资金
- Science Foundation Ireland [08/IN.1/B2104]
- Science Foundation Ireland (SFI) [08/IN.1/B2104] Funding Source: Science Foundation Ireland (SFI)
The first decade of transcriptomic studies of Salmonella enterica serovar Typhimurium focused upon gene expression in vitro, and during the infection of mammalian cells. The published regulons and stimulons show that the three Type Three Secretion Systems of S. Typhimurium respond to a diverse range of environmental conditions, and are controlled by a hierarchy of regulatory proteins. The integration of in vitro generated transcriptomic data with global gene expression of S. Typhimurium during infection is beginning to yield valuable information. The coordinated regulation of Salmonella gene expression is a key process for survival, adaptation and virulence capacities of the pathogen.
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